/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-05-09T06:46:07-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/05/09/your_brain_shifts_gears.php Want to be weirded out? Study the central nervous system. I started off my med-chem career in CNS drug discovery, and it's still my standard for impenetrability. There's a new paper in Science, though, that just makes you roll your... 76401@/home/corante/public_html/pipeline/ The Central Nervous System 2013-05-09T06:46:07-05:00 http://pipeline.corante.com/archives/2013/04/02/tecfideras_price.php Let us take up the case of Tecfidera, the new Biogen/Idec drug for multiple sclerosis, known to us chemists as dimethyl fumarate. It joins the (not very long) list of industrial chemicals (the kind that can be purchased in railroad-car... 76320@/home/corante/public_html/pipeline/ Drug Prices 2013-04-02T06:41:57-05:00 http://pipeline.corante.com/archives/2013/03/21/neurosearchs_decline.php If you looked at the timelines of a clinical trial, you'll notice that there's often a surprisingly long gap between when the trial actually ends and when the results of it are ready to announce. If you've ever been involved... 76290@/home/corante/public_html/pipeline/ Clinical Trials 2013-03-21T11:23:07-05:00 http://pipeline.corante.com/archives/2013/01/18/a_short_rise_out_of_depression.php Here's another one to file under "What we don't know about brain chemistry". That's a roomy category for sure, which (to be optimistic about it) leaves a lot of room for discovery. In that category are the observations that ketamine... 76149@/home/corante/public_html/pipeline/ Clinical Trials 2013-01-18T07:53:23-05:00 http://pipeline.corante.com/archives/2013/01/10/automated_ligand_design.php There's a paper out in Nature with the provocative title of "Automated Design of Ligands to Polypharmcological Profiles". Admittedly, to someone outside my own field of medicinal chemistry, that probably sounds about as dry as the Atacama desert, but it... 76128@/home/corante/public_html/pipeline/ In Silico 2013-01-10T09:37:46-05:00 http://pipeline.corante.com/archives/2012/12/20/cns_drug_development_claims_another_victim.php Tiny Allon Therapeutics had an ambitious plan to go after progressive supranuclear palsy, a kind of progressive brain deterioration, and thence (they hoped) to other neurodegenerative disorders. The lead compound was davunetide, an oligopeptide derived from activity-dependent neuroprotective protein, ADNP.... 76088@/home/corante/public_html/pipeline/ The Central Nervous System 2012-12-20T07:39:30-05:00 http://pipeline.corante.com/archives/2012/11/23/more_on_that_crowdsourced_cns_research.php I wanted to mention that the crowdfunded CNS research that I mentioned here is now in its final 48 hours for donations. Money seems to be picking up, but it'll be close to see if they can make their target.... 76019@/home/corante/public_html/pipeline/ The Central Nervous System 2012-11-23T14:16:28-05:00 http://pipeline.corante.com/archives/2012/10/18/the_generic_wellbutrin_problem_whose_fault_is_it.php One of the questions I get asked most often, by people outside of the drug industry, is whether generic medications really are the same as the original branded ones. My answer has always been the same: that yes, they are.... 75941@/home/corante/public_html/pipeline/ Regulatory Affairs 2012-10-18T06:29:53-05:00 http://pipeline.corante.com/archives/2012/10/08/targacept_cuts_way_back.php It hasn't been good over at Targacept. They had a big antidepressant failure a while back, and last month ended development of an ADHD drug, the nicotinic acetylcholine receptor ligand TC-5619. They cut back staff back in the spring, and... 75917@/home/corante/public_html/pipeline/ The Central Nervous System 2012-10-08T10:21:52-05:00 http://pipeline.corante.com/archives/2012/10/05/crowdfunding_a_cns_project.php Ethan Perlstein at Princeton is the main author of this research on sertraline that I blogged about earlier this year. Now he's looking to crowdfund his next research project, on the neuronal effects of amphetamines. He's trying to raise $25,000... 75912@/home/corante/public_html/pipeline/ The Central Nervous System 2012-10-05T06:32:58-05:00 http://pipeline.corante.com/archives/2012/09/20/various_links_of_stuff.php Swamped with all sorts of stuff today - when science marches on, you have to make sure that it's not leaving its bootprints on your back. But I do have some interesting links: The bluest of blue-sky brain research, funded... 75874@/home/corante/public_html/pipeline/ The Central Nervous System 2012-09-20T10:02:01-05:00 http://pipeline.corante.com/archives/2012/08/31/eli_lillys_drumbeat_of_bad_news.php Eli Lilly has been getting shelled with bad news recently. There was the not-that-encouraging-at-all failure of its Alzheimer's antibody solanezumab to meet any of its clinical endpoints. But that's the good news, since that (at least according to the company)... 75843@/home/corante/public_html/pipeline/ Cardiovascular Disease 2012-08-31T06:42:15-05:00 http://pipeline.corante.com/archives/2012/08/14/is_ampyra_any_good.php I wrote here about Ampyra, the multiple sclerosis drug from Acorda Therapeutics, one that came close to the record for "simplest chemical matter in a marketed drug". (As it happens, Biogen Idec is making sure that it doesn't even have... 75807@/home/corante/public_html/pipeline/ Clinical Trials 2012-08-14T06:47:16-05:00 http://pipeline.corante.com/archives/2012/08/09/getting_drug_research_really_really_wrong.php The British Medical Journal says that the "widely touted innovation crisis in pharmaceuticals is a myth". The British Medical Journal is wrong. There, that's about as direct as I can make it. But allow me to go into more detail,... 75801@/home/corante/public_html/pipeline/ Business and Markets 2012-08-09T10:45:39-05:00 http://pipeline.corante.com/archives/2012/08/08/closure_at_the_neurosciences_institute.php There doesn't seem to be any mention of it on their web site, but the Neurosciences Institute in San Diego/La Jolla may be closing up shop. A reader received an e-mail about a lab equipment auction at that address, and... 75799@/home/corante/public_html/pipeline/ The Central Nervous System 2012-08-08T07:43:56-05:00