/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-01-23T11:12:20-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/01/23/eating_a_whole_bunch_of_random_compounds.php Reader Andy Breuninger, from completely outside the biopharma business, sends along what I think is an interesting question, and one that bears on a number of issues: A question has been bugging me that I hope you might answer. My... 76157@/home/corante/public_html/pipeline/ Drug Assays 2013-01-23T11:12:20-05:00 http://pipeline.corante.com/archives/2012/10/23/improving_halflife.php There was a question in the comments from a reader who's picking up med-chem, and I thought it was worth answering out here. I've been meaning to shore up the "Pharma 101" category, and this is a good opportunity. So... 75954@/home/corante/public_html/pipeline/ Pharmacokinetics 2012-10-23T09:12:55-05:00 http://pipeline.corante.com/archives/2012/06/08/lessons_for_a_new_medicinal_chemist.php I gave my talk at the Drew University Medicinal Chemistry course, and it got me to thinking about when I was there (1990 or 1991), and my early days in medicinal chemistry in general. There are a lot of things... 75692@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-06-08T07:34:54-05:00 http://pipeline.corante.com/archives/2012/04/27/how_do_drugs_get_into_cells_a_vicious_debate.php So how do drug molecules (and others) get into cells, anyway? There are two broad answers: they just sort of slide in through the membranes on their own (passive diffusion), or they're taken up by pores and proteins built for... 75598@/home/corante/public_html/pipeline/ Pharma 101 2012-04-27T08:01:46-05:00 http://pipeline.corante.com/archives/2010/03/02/why_you_dont_want_to_make_deathstarsized_drugs.php I was just talking about greasy compounds the other day, and reasons to avoid them. Right on cue, there's a review article in Expert Opinion in Drug Discovery on lipophilicity. It has some nice data in it, and I wanted... 74306@/home/corante/public_html/pipeline/ Pharma 101 2010-03-02T08:07:15-05:00 http://pipeline.corante.com/archives/2009/11/19/what_are_the_best_medchem_books.php I get regular requests to recommend books on various aspects of medicinal chemistry and drug development. And while I have a few things on my list, I'm sure that I'm missing many more. So I wanted to throw this out... 74151@/home/corante/public_html/pipeline/ Pharma 101 2009-11-19T11:51:55-05:00 http://pipeline.corante.com/archives/2009/08/13/animal_testing_a_view_from_the_labs.php Why do we test drugs on animals, anyway? This question showed up in the comments section from a lay reader. It's definitely a fair thing to ask, and you'd expect that we in the business would have a good answer.... 74015@/home/corante/public_html/pipeline/ Animal Testing 2009-08-13T06:24:53-05:00 http://pipeline.corante.com/archives/2009/02/06/prep_tlc_the_good_old_days_live_on.php I did something in the lab the other day that I hadn’t done in several years: run some preparative TLC plates. I had some small reactions that needed to be cleaned up, and the HPLC systems were all in use,... 73725@/home/corante/public_html/pipeline/ Pharma 101 2009-02-06T08:29:21-05:00 http://pipeline.corante.com/archives/2008/12/10/floppiness_is_not_your_friend_who_knew.php There’s a trick that every medicinal chemist learns very early, and continues to apply every time its feasible: take two parts of your compound, and tie them together into a ring. The reason that works so well may not be... 73644@/home/corante/public_html/pipeline/ In Silico 2008-12-10T10:11:21-05:00 http://pipeline.corante.com/archives/2007/08/30/elbow_room.php I hope that in decades to come that our current drugs look as crude as I think they will. For all of our knowledge and all our equipment, we still don't have much of an idea of what we're doing... 72656@/home/corante/public_html/pipeline/ Drug Development 2007-08-30T06:09:01-05:00 http://pipeline.corante.com/archives/2007/08/28/like_clockwork.php There are a lot of drug development issues that people outside the field (and beginning medicinal chemists) don't think about. A significant one that sounds trivial is how often your wonder drug is going to be taken. Once a day... 72653@/home/corante/public_html/pipeline/ Drug Development 2007-08-28T21:37:32-05:00 http://pipeline.corante.com/archives/2007/07/15/proteomics_101.php Over at the entertaining culture-blog 2Blowhards, the comments to this post (on people who feel deficient in math ability) include a mention of proteomics, which prompted Michael Blowhard to say: "Proteomics" -- even the word is scary. I wonder how... 72492@/home/corante/public_html/pipeline/ Pharma 101 2007-07-15T15:37:42-05:00