/home/corante/public_html/pipeline/ en-us derek-lowe@sbcglobal.net 2009-11-23T08:13:48-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2009/11/23/ozonides_as_drugs_what_will_they_think_of_next.php You know, I often think that I have too narrow a view of what kinds of structures can go into drug molecules. (That may come as worrisome statement for some past and present colleagues of mine, who feel that my... 74157@/home/corante/public_html/pipeline/ Odd Elements in Drugs 2009-11-23T08:13:48-05:00 http://pipeline.corante.com/archives/2007/11/02/one_for_the_brave.php I was interested to see a recent paper in Organic Letters on a class of compounds I'd never seen before: 1,2-dihydro-1,2-azaborines. There's the structure, in case that doesn't immediately call something to mind. These things, which are isoelectronic with benzene,... 72832@/home/corante/public_html/pipeline/ Chemical News 2007-11-02T09:36:23-05:00 http://pipeline.corante.com/archives/2007/09/17/arsenic_patents_and_the_world.php As I was mentioning the other day, the latest issue of Nature Medicine has the details on a story that doesn’t, on the face of it, do the industry any credit. About twenty years ago, there were reports out of... 72681@/home/corante/public_html/pipeline/ 2007-09-17T08:25:59-05:00 http://pipeline.corante.com/archives/2006/01/08/my_shopping_list.php Some time ago I wrote about some atoms that I wish I could use. There are still other molecular fragments that Nature has neglected to provide, though, and I'm adding to the wish list: First off, I'd like some groups... 45740@/home/corante/public_html/pipeline/ Odd Elements in Drugs 2006-01-08T23:05:29-05:00 http://pipeline.corante.com/archives/2004/05/02/odd_elements_in_drugs_silicon.php Another chemical element that you don't see much in pharmaceuticals is silicon. Hey, it's right under carbon in the periodic table, and forms four tetrahedral bonds just like carbon does, so why not, eh? Now, if you're like me, you... 10947@/home/corante/public_html/pipeline/ Drug Development 2004-05-02T21:54:16-05:00 http://pipeline.corante.com/archives/2004/04/19/odd_elements_in_drugs.php I had a question recently about why some chemical elements don't appear much in pharmaceuticals. Boron was one example - the first boron-containing drug (Velcade, from Millennium) was approved just recently. But it hasn't been for lack of trying. Starting... 10936@/home/corante/public_html/pipeline/ Odd Elements in Drugs 2004-04-19T21:25:38-05:00