/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2012-11-02T07:20:41-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2012/11/02/sudden_onset_of_promiscuity.php That title should bring in the hits. But don't get your hopes up! This is medicinal chemistry, after all. "Can't you just put the group in your molecule that does such-and-such?" Medicinal chemists sometimes hear variations of that question from... 75978@/home/corante/public_html/pipeline/ Drug Assays 2012-11-02T07:20:41-05:00 http://pipeline.corante.com/archives/2011/08/26/kibdelomycin_a_new_antibiotic_in_a_way.php We're going to need new antibiotics. Everyone knows this, and it's not like no one's been trying to do anything about it, either, but. . .we're still going to need more of them than we have. I'm not predicting that... 75154@/home/corante/public_html/pipeline/ Infectious Diseases 2011-08-26T07:32:17-05:00 http://pipeline.corante.com/archives/2010/12/15/chiral_what_chiral_how.php Thanks to an email from a reader, I can bring you this very weird paper from Tetrahedron. The authors claim to have extracted a local plant and isolated nevirapine, (sold as Viramune by Boehringer Ingleheim as a reverse transcriptase inhibitor... 74795@/home/corante/public_html/pipeline/ The Scientific Literature 2010-12-15T08:36:45-05:00 http://pipeline.corante.com/archives/2010/11/11/and_one_was_just_right.php I've been reading an interesting new paper from Stuart Schreiber's research group(s) in PNAS. But I'm not sure if the authors and I would agree on the reasons that it's interesting. This is another in the series that Schreiber has... 74754@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2010-11-11T07:29:33-05:00 http://pipeline.corante.com/archives/2010/08/26/vinca_alkaloids_and_where_they_end_up.php The Vinca alkaloids are some of the most famous chemotherapy drugs around - vincristine and vinblastine, the two most widely used, are probably shown in every single introduction to natural products chemistry that's been written in the past fifty years.... 74639@/home/corante/public_html/pipeline/ Biological News 2010-08-26T09:04:05-05:00