/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-01-28T10:58:26-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/01/28/the_hydrophobic_effect_i_dont_understand_it_either.php We medicinal chemists talk a good game when it comes to the the hydrophobic effect. It's the way that non-water-soluble molecules (or parts of molecules) like to associate with each other, right? Sure thing. And it works because of. .... 76167@/home/corante/public_html/pipeline/ In Silico 2013-01-28T10:58:26-05:00 http://pipeline.corante.com/archives/2012/08/13/donald_light_responds_on_drug_innovation_and_costs.php Here's a response from Prof. Light to my post the other day attacking his positions on drug research. I've taken it out of that comments thread to highlight it - he no longer has to wonder if I'll let people... 75805@/home/corante/public_html/pipeline/ "Me Too" Drugs 2012-08-13T06:43:45-05:00 http://pipeline.corante.com/archives/2012/08/09/getting_drug_research_really_really_wrong.php The British Medical Journal says that the "widely touted innovation crisis in pharmaceuticals is a myth". The British Medical Journal is wrong. There, that's about as direct as I can make it. But allow me to go into more detail,... 75801@/home/corante/public_html/pipeline/ Business and Markets 2012-08-09T10:45:39-05:00 http://pipeline.corante.com/archives/2011/05/05/translation_needed.php The "Opinionator" blog at the New York Times is trying here, but there's something not quite right. David Bornstein, in fact, gets off on the wrong foot entirely with this opening: Consider two numbers: 800,000 and 21. The first is... 74980@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2011-05-05T06:11:54-05:00 http://pipeline.corante.com/archives/2011/01/26/those_metoo_drugs.php So, me-too drugs, knock-offs, copycats: what say you? If you're a critic of the industry, you generally say quite a bit, and it's about lack of innovation, seeking easy profits and playing it safe, putting marketing over science, and so... 74837@/home/corante/public_html/pipeline/ "Me Too" Drugs 2011-01-26T07:30:32-05:00 http://pipeline.corante.com/archives/2010/05/18/biosimilars_not_so_dang_easy.php This post drew a lot of comments here about how the big companies are going after follow-on biologic drugs. As a late-2008 article put it: Merck already has one FOB in clinical development: a pegylated erythropoietin for anemia similar to... 74475@/home/corante/public_html/pipeline/ "Me Too" Drugs 2010-05-18T11:26:50-05:00 http://pipeline.corante.com/archives/2010/04/28/pfizers_future_biotech_followups.php The Wall Street Journal has an article detailing some of Pfizer's plans in the biologics area: stepping in with second-generation versions of current winners from other companies. New versions of Rituxan and Enbrel are in the works, with the improvements... 74431@/home/corante/public_html/pipeline/ "Me Too" Drugs 2010-04-28T11:35:02-05:00 http://pipeline.corante.com/archives/2009/08/24/arzoxifene_not_the_road_to_big_profits.php Eli Lilly announced some bad news last week when they dropped arzoxifene, a once-promising osteoporosis treatment (and successor to Evista (raloxifene), which has been one of the company's big successes). If this drug had been found ten or fifteen years... 74035@/home/corante/public_html/pipeline/ "Me Too" Drugs 2009-08-24T07:13:48-05:00 http://pipeline.corante.com/archives/2008/03/19/now_your_liver_doesnt_have_to_make_it_for_you.php One of the less appealing ways that companies have tried to fill their drug portfolios over the years has been to look through their current drugs in search of one with a main active metabolite. That altered structure then becomes... 73170@/home/corante/public_html/pipeline/ Why Everyone Loves Us 2008-03-19T07:15:31-05:00 http://pipeline.corante.com/archives/2008/02/04/how_many_ppis_does_the_world_need.php The topic of “me too” drugs has come up quite a bit around here over the years. For the most part, I’m a defender, although there are some places I draw the line (Clarinex for Claritin comes to mind as... 73082@/home/corante/public_html/pipeline/ "Me Too" Drugs 2008-02-04T08:35:24-05:00 http://pipeline.corante.com/archives/2007/11/28/bad_luck_for_novartis_and_for_diabetics.php Novartis must wonder what they did to deserve this one. A few years ago, it looked as if they ruled the potentially lucrative world of dipeptidylylpeptidase-IV (DPP-IV) inhibitors for diabetes. (Note - name of enzyme corrected after brain hiccup -... 72900@/home/corante/public_html/pipeline/ "Me Too" Drugs 2007-11-28T21:35:32-05:00 http://pipeline.corante.com/archives/2007/07/24/godzilla_vs_mothra_relman_vs_epstein.php Arnold Relman is back. The co-author, with Marcia Angell, of The Truth About The Drug Companies, has a long review in The New Republic of Richard Epstein's new book on the industry, Overdose. Not everything in Epstein's book is right,... 72517@/home/corante/public_html/pipeline/ Drug Prices 2007-07-24T19:36:54-05:00 http://pipeline.corante.com/archives/2005/09/22/by_a_nose_in_a_head_to_head.php One of the other incorrect lessons that people might take away from the press accounts of the antipsychotic trial is that drug companies have been comparing their medications to placebo too often. And why would you do that unless you... 11308@/home/corante/public_html/pipeline/ "Me Too" Drugs 2005-09-22T20:58:02-05:00 http://pipeline.corante.com/archives/2005/09/21/no_clear_winners.php You've probably seen the headlines about the recent NIH-sponsored "CATIE" study comparing five anti-psychotic medications. The result, which is what made the whole thing newsworthy to the popular press, was that it was hard to distinguish among them, with the... 11307@/home/corante/public_html/pipeline/ The Central Nervous System 2005-09-21T20:53:41-05:00 http://pipeline.corante.com/archives/2005/08/23/gritting_our_teeth.php I'll tell you a company that's been watching what's happened to Merck and thinking hard about it: Sanofi. Well, OK, everyone in the industry has been looking at Merck's situation and shuddering, but I suspect the people at Sanofi(-Aventis) are... 11285@/home/corante/public_html/pipeline/ "Me Too" Drugs 2005-08-23T21:48:00-05:00