/home/corante/public_html/pipeline/ en-us derek-lowe@sbcglobal.net 2009-11-20T10:53:25-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2009/11/20/but_these_reagents_where_are_they.php I'm home today (sick children, etc.), so I'm blogging from next to my daughter's guinea pig cage rather across the hall from my lab. But I have a lab-based question to throw out: what would you say is the chemistry... 74155@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-11-20T10:53:25-05:00 http://pipeline.corante.com/archives/2009/11/19/what_are_the_best_medchem_books.php I get regular requests to recommend books on various aspects of medicinal chemistry and drug development. And while I have a few things on my list, I'm sure that I'm missing many more. So I wanted to throw this out... 74151@/home/corante/public_html/pipeline/ Pharma 101 2009-11-19T11:51:55-05:00 http://pipeline.corante.com/archives/2009/11/13/lumpy_assay_results.php When we screen zillions of compounds from our files against a new drug target, what can we expect? How many hits will we get, and what percentage of those are actually worth looking at in more detail? These are long-running... 74141@/home/corante/public_html/pipeline/ Drug Assays 2009-11-13T08:53:13-05:00 http://pipeline.corante.com/archives/2009/11/10/lab_equipment_any_hcube_troubleshooters_out_there.php I mentioned the H-Cube hydrogenation machine here a couple of years ago as an early example of a commercial flow chemistry machine. As some readers may have guessed, my recent post on hydrogenations was partly inspired by a recent run... 74134@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-11-10T10:20:58-05:00 http://pipeline.corante.com/archives/2009/10/29/four_medchem_questions.php Here are a few more of those questions that medicinal chemists have to deal with from time to time. Most of these have no definitive answers (which is why they keep coming up!) 1. You're making a compound that looks... 74116@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-10-29T08:11:07-05:00 http://pipeline.corante.com/archives/2009/10/27/reduce_your_number_of_reductions_why_dont_you.php I've been occupied all morning with voodoo. Well, the technical name for it is catalytic hydrogenation, but let's call it for what it is: witchcraft. It's a widely used reaction in organic chemistry, and you can use it to reduce... 74113@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-10-27T10:43:48-05:00 http://pipeline.corante.com/archives/2009/10/26/elements_i_have_yet_to_use.php I wrote about this topic a few years ago, and thought I'd update it. Many chemists find themselves looking at a periodic table and wondering "How many of these things have I personally handled?" My list is up to nearly... 74112@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-10-26T07:48:11-05:00 http://pipeline.corante.com/archives/2009/10/14/consultants.php Most chemistry departments in the drug industry have some academic consultants who come in every so often. The idea is that they'll have some useful suggestions about synthetic problems (there aren't so many academic consultants who are useful on drug... 74096@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-10-14T07:45:16-05:00 http://pipeline.corante.com/archives/2009/10/08/hoist_petard_etc.php Hmmm. As a colleague just pointed out to me, I've spent some time here defending "me-too" drugs. And just this morning (see the previous post) I take off after what can only be described as "me-too reactions", saying that I... 74090@/home/corante/public_html/pipeline/ Chemical News 2009-10-08T13:31:09-05:00 http://pipeline.corante.com/archives/2009/10/08/retire_these_reactions.php Here's a question you don't hear discussed very often: are there some synthetic organic chemistry reactions that don't need any more work? I'm moved to ask this because I just came across yet another way that someone has reported to... 74089@/home/corante/public_html/pipeline/ Chemical News 2009-10-08T07:32:46-05:00 http://pipeline.corante.com/archives/2009/09/22/colorful_junk.php Last Saturday night I stayed out until 3:30 AM, then slept in the back of our van. Now, that may sound like a pretty good evening for some of you, but it might seem a little odd for a guy... 74068@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-09-22T06:57:04-05:00 http://pipeline.corante.com/archives/2009/08/12/sulfoxides_a_sneaking_affection.php Let us now praise sulfur. Well, some kinds of sulfur, anyway. The +2 oxidation state (earlier typo fixed, aargh) is a bit hard to handle, what with all those angry-skunk, burnt-tire overtones. But move up the ladder to +4, and... 74012@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-08-12T07:26:24-05:00 http://pipeline.corante.com/archives/2009/08/07/how_a_real_drug_industry_project_meeting_goes.php For those who don't work in the industry, and wonder what goes on behind the closed doors of the research buildings, allow me to give you a fly-on-the-wall view of a typical meeting of a drug discovery project team. There... 74003@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-08-07T08:00:19-05:00 http://pipeline.corante.com/archives/2009/07/20/everything_in_its_place.php Things are pretty quiet around the industry these days, so my blogging thoughts have been turning to Big General Problems. And here's one that I know that people are working on, but which I think we as chemists are going... 73984@/home/corante/public_html/pipeline/ Chemical News 2009-07-20T07:38:01-05:00 http://pipeline.corante.com/archives/2009/07/14/rur.php What does it take for a new technology to catch on in the labs? There's an endless stream of candidates (I hope it's endless, anyway), from small gizmos that you can keep in your drawer to multi-hundred-thousand-dollar machines that need... 73977@/home/corante/public_html/pipeline/ Life in the Drug Labs 2009-07-14T08:41:41-05:00