/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-04-22T06:45:53-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/04/22/real_reactions_from_real_lab_notebooks.php Over at NextMove software, they have an analysis of what kinds of reactions are being run most often inside a large drug company. Using the company's electronic notebook database and their own software, they can get a real-world picture of... 76357@/home/corante/public_html/pipeline/ Life in the Drug Labs 2013-04-22T06:45:53-05:00 http://pipeline.corante.com/archives/2013/04/10/old_friends_and_those_other_guys.php I have affection for some reagents, and have taken a dislike to others. That might be seen as odd, because if there's anything that can't return your feelings, it's a chemical reagent. But after some years in the lab, you... 76337@/home/corante/public_html/pipeline/ Life in the Drug Labs 2013-04-10T07:09:43-05:00 http://pipeline.corante.com/archives/2013/03/07/ill_just_take_a_tour_of_your_lab_drawers_here.php I enjoyed this from postdoc JesstheChemist on Twitter: "Busted. Just caught someone (who doesn't work in my lab) going through my lab drawers." Now that's a real-life lab comment if I ever saw one. It's a constant feature in academic... 76265@/home/corante/public_html/pipeline/ Life in the Drug Labs 2013-03-07T10:11:04-05:00 http://pipeline.corante.com/archives/2013/03/01/the_finest_green_in_the_lab.php For Friday afternoon, I thought I'd put up another color post. That's nickel (II) chloride hydrate, and the only time I've used it was in a modified borohydride reduction. But that was a glorious prep, at least until the borohydride... 76248@/home/corante/public_html/pipeline/ Life in the Drug Labs 2013-03-01T13:31:38-05:00 http://pipeline.corante.com/archives/2013/02/15/the_finest_blue_in_the_lab.php For Friday afternoon, a bit of chem-geekery. I recently had occasion to use some copper sulfate, and the bottle I had was marked "large crystals" of the pentahydrate. I have loved the color of that stuff since I was... 76216@/home/corante/public_html/pipeline/ Life in the Drug Labs 2013-02-15T11:47:21-05:00 http://pipeline.corante.com/archives/2013/01/28/asking_the_hard_questions.php Well, it is a hard question, and I don't know the answer, either. On Twitter, See Arr Oh wonders: Know that tangy smell that LAH / NaH give off? Is that oil volatiles, or trace H2 being formed from room... 76168@/home/corante/public_html/pipeline/ Life in the Drug Labs 2013-01-28T13:02:59-05:00 http://pipeline.corante.com/archives/2013/01/25/down_with_the_ullmann.php Have I mentioned recently what a pain the rear the Ullmann reaction is? Copper, in general? Consider it done, then. I'm trying to make biaryl ethers, not something I'd usually do, and these reactions are the traditional answer. One of... 76164@/home/corante/public_html/pipeline/ Life in the Drug Labs 2013-01-25T11:20:19-05:00 http://pipeline.corante.com/archives/2013/01/04/an_article_that_shows_what_medchem_is_like.php Here's a query that I received the other day that I thought I'd pass on to the readership: "What's the one journal article or book chapter that you'd assign to a class to show them what medicinal chemistry and drug... 76110@/home/corante/public_html/pipeline/ The Scientific Literature 2013-01-04T07:08:34-05:00 http://pipeline.corante.com/archives/2012/11/27/how_do_chemist_think_that_they_judge_compounds.php There's an interesting paper out in PLoS One, called "Inside the Mind of a Medicinal Chemist". Now, that's not necessarily a place that everyone wants to go - mine is not exactly a tourist trap, I can tell you -... 76025@/home/corante/public_html/pipeline/ Life in the Drug Labs 2012-11-27T09:19:26-05:00 http://pipeline.corante.com/archives/2012/11/16/sulfolane.php Here's a paper that I missed in Organic Process Research and Development earlier this year, extolling the virtues of sulfolane as a high-temperature polar solvent. I have to say, I've never used it, although I hear of it being used... 76007@/home/corante/public_html/pipeline/ Chemical News 2012-11-16T13:23:05-05:00 http://pipeline.corante.com/archives/2012/11/05/caring_about_yields.php The discussion here last week about exaggerated reaction yields has gotten me thinking. I actually seem to go for long periods without ever calculating (or caring much) about the yields of my reactions. That's largely because of the sort of... 75979@/home/corante/public_html/pipeline/ Life in the Drug Labs 2012-11-05T08:10:46-05:00 http://pipeline.corante.com/archives/2012/10/24/chem_coach_carnival_a_few_questions.php Over at Just Like Cooking, See Arr Oh has been organizing a "Chem Coach Carnival". He's asking chemists (blogging and otherwise) some questions about their work, especially for the benefit of people who don't do it (or not yet), and... 75958@/home/corante/public_html/pipeline/ General Scientific News 2012-10-24T08:33:24-05:00 http://pipeline.corante.com/archives/2012/09/11/careers_and_those_words_stuck_and_advance.php A recent comment to another post prompts this entry. Regarding getting a chemistry PhD and getting a job, it reads: . . .However, transitioning into corporate pharma was a big if not bigger challenge in some ways. It took a... 75857@/home/corante/public_html/pipeline/ Life in the Drug Labs 2012-09-11T07:33:46-05:00 http://pipeline.corante.com/archives/2012/08/24/the_good_ol_dielsalder.php Over at Chemistry Blog, there's a post by Quintus on the synthesis of a complex natural product, FR-182877. The route is interesting in that it features a key Diels-Alder reaction, and the post mentions that this isn't a reaction that... 75832@/home/corante/public_html/pipeline/ Life in the Drug Labs 2012-08-24T06:37:16-05:00 http://pipeline.corante.com/archives/2012/08/22/watch_that_little_letter_c.php Hang around a bunch of medicinal chemists (no, really, it's more fun than you'd think) and you're bound to hear discussion of cLogP. For the chemists in the crowd, I should warn you that I'm about to say nasty things... 75825@/home/corante/public_html/pipeline/ In Silico 2012-08-22T06:57:22-05:00