/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-05-17T07:01:57-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/05/17/a_little_ranbaxy_example.php Compare and contrast. Here we have Krishnan Ramalingam, from Ranbaxy's Corporate Communications department, in 2006: Being a global pharmaceutical major, Ranbaxy took a deliberate decision to pool its resources to fight neglected disease segments. . .Ranbaxy strongly felt that generic... 76422@/home/corante/public_html/pipeline/ Infectious Diseases 2013-05-17T07:01:57-05:00 http://pipeline.corante.com/archives/2013/05/07/another_germ_theory_victory_back_pain.php The "New Germ Theory" people may have notched up another one: a pair of reports out from a team in Denmark strongly suggest that many cases of chronic low back pain are due to low-grade bacterial infection. They've identified causative... 76396@/home/corante/public_html/pipeline/ Infectious Diseases 2013-05-07T11:21:07-05:00 http://pipeline.corante.com/archives/2013/03/14/does_baldness_get_more_funding_than_malaria.php OK, let's fact-check Bill Gates today, shall we? Capitalism means that there is much more research into male baldness than there is into diseases such as malaria, which mostly affect poor people, said Bill Gates, speaking at the Royal Academy... 76278@/home/corante/public_html/pipeline/ Drug Development 2013-03-14T08:01:39-05:00 http://pipeline.corante.com/archives/2013/02/28/ibms_watson_does_drug_discovery.php I saw this story this morning, about IBM looking for more markets for its Watson information-sifting system (the one that performed so publicly on "Jeopardy". And this caught my eye for sure: John Baldoni, senior vice president for technology and... 76246@/home/corante/public_html/pipeline/ In Silico 2013-02-28T13:38:21-05:00 http://pipeline.corante.com/archives/2013/02/13/mouse_models_of_inflammation_are_basically_worthless_now_we_know.php We go through a lot of mice in this business. They're generally the first animal that a potential drug runs up against: in almost every case, you dose mice to check pharmacokinetics (blood levels and duration), and many areas have... 76210@/home/corante/public_html/pipeline/ Animal Testing 2013-02-13T08:21:41-05:00 http://pipeline.corante.com/archives/2013/01/24/three_rings_in_a_row.php Here's a structure that caught me eye, in this paper from Georgia State and Purdue. That's a nice-looking group stuck on the side of their HIV protease inhibitor; I don't think I've ever seen three fused THF rings before,... 76161@/home/corante/public_html/pipeline/ Infectious Diseases 2013-01-24T11:00:54-05:00 http://pipeline.corante.com/archives/2013/01/15/is_obesity_an_infectious_disease.php Like many people, I have a weakness for "We've had it all wrong!" explanations. Here's another one, or part of one: is obesity an infectious disease? During our clinical studies, we found that Enterobacter, a genus of opportunistic, endotoxin-producing pathogens,... 76138@/home/corante/public_html/pipeline/ Diabetes and Obesity 2013-01-15T07:57:51-05:00 http://pipeline.corante.com/archives/2012/10/08/nasty_drug_molecules_amphotericin_b.php You've probably seen the headlines about fungal meningitis showing up, caused (it appears) by contaminated injectable steroid supplies. As soon as I heard these stories, I wondered what you treat this condition with, and my first thought was "Amphotericin B,... 75915@/home/corante/public_html/pipeline/ Infectious Diseases 2012-10-08T07:22:25-05:00 http://pipeline.corante.com/archives/2012/09/04/a_new_malaria_compound.php There have been many headlines in recent days about a potential malaria cure. I'm not sure what set these off at this time, since the paper describing the work came out back in the spring, but it's certainly worth a... 75845@/home/corante/public_html/pipeline/ Infectious Diseases 2012-09-04T08:01:29-05:00 http://pipeline.corante.com/archives/2012/05/21/a_new_way_to_kill_amoebas_from_an_old_drug.php Here's a good example of phenotypic screening coming through with something interesting and worthwhile: they screened against Entamoeba histolytica, the protozooan that causes amoebic dysentery and kills tens of thousands of people every year. (Press coverage here). It wasn't easy.... 75648@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-05-21T12:14:00-05:00 http://pipeline.corante.com/archives/2012/05/21/a_molecular_craigslist.php Mat Todd at the University of Sydney (whose open-source drug discovery work on schistosomiasis I wrote about here) has an interesting chemical suggestion. His lab is also involved in antimalarial work (here's an update, for those interested, and I hope... 75647@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-05-21T08:46:47-05:00 http://pipeline.corante.com/archives/2012/04/30/indias_first_drug_isnt_indias_first_drug.php There have been a number of headlines the last few days about Ranbaxy's Synriam, an antimalarial that's being touted as the first new drug developed inside the Indian pharma industry (and Ranbaxy as the first Indian company to do it).... 75600@/home/corante/public_html/pipeline/ Infectious Diseases 2012-04-30T07:13:35-05:00 http://pipeline.corante.com/archives/2012/04/25/dhfr_inhibitors_revisited_a_word_from_the_authors_and_reviewers.php The other day, I had some uncomplimentary things to say about a recent J. Med. Chem. paper on fragment-based dihydrofolate reductase inhibitors. Well, I know that I don't say these things into a vacuum, by any means, but in this... 75595@/home/corante/public_html/pipeline/ Drug Assays 2012-04-25T20:31:28-05:00 http://pipeline.corante.com/archives/2012/04/18/how_do_these_things_get_published.php Update: I've heard from both the lead author of this paper and one of its reviewers, and I've written a follow-up post on this subject, as well as revising this one where shown below. I've been saved the trouble of... 75577@/home/corante/public_html/pipeline/ The Scientific Literature 2012-04-18T08:54:27-05:00 http://pipeline.corante.com/archives/2012/03/05/trouble_with_a_boroncontaining_drug_candidate.php There have been all kinds of boronic acid-based enzyme inhibitors over the years, but they've been mostly locked in the spacious closet labeled "tool compounds". That's as opposed to drugs. After all these years, Velcade is still the only marketed... 75499@/home/corante/public_html/pipeline/ Odd Elements in Drugs 2012-03-05T07:35:08-05:00