/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-06-18T07:55:21-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/06/18/bernard_munos_on_the_last_twelve_years_of_pharma.php Bernard Munos (ex-Lilly, now consulting) is out with a paper reviewing the approved drugs from 2000 to 2012. What's the current state of the industry? Is the upturn in drug approvals over the last two years real, or an artifact?... 76485@/home/corante/public_html/pipeline/ Drug Development 2013-06-18T07:55:21-05:00 http://pipeline.corante.com/archives/2013/06/14/one_million_pounds_for_a_new_antibiotic.php Via Stuart Cantrill on Twitter, I see that UK Prime Minister David Cameron is prepared to announce a prize for anyone who can "identify and solve the biggest problem of our time". He's leaving that open, and his examples are... 76478@/home/corante/public_html/pipeline/ Who Discovers and Why 2013-06-14T07:58:35-05:00 http://pipeline.corante.com/archives/2013/05/28/valeant_versus_genentech_two_different_worlds.php Readers may recall the bracing worldview of Valeant CEO Mike Pearson. Here's another dose of it, courtesy of the Globe and Mail. Pearson, when he was brought in from McKinsey, knew just what he wanted to do: Pearson’s next suggestion... 76438@/home/corante/public_html/pipeline/ Business and Markets 2013-05-28T08:00:40-05:00 http://pipeline.corante.com/archives/2013/05/20/but_dont_drug_companies_spend_more_on_marketing.php So drug companies may spend a lot on R&D, but they spend even more on marketing, right? I see the comments are already coming in to that effect on this morning's post on R&D expenditures as a percentage of revenues.... 76428@/home/corante/public_html/pipeline/ Business and Markets 2013-05-20T10:50:49-05:00 http://pipeline.corante.com/archives/2013/05/20/how_much_do_drug_companies_spend_on_rd_anyway.php How much does Big Pharma spend on R&D, compared to what it takes in? This topic came up during a discussion here last week, when a recent article at The Atlantic referred to these expenditures as "only" 16 cents on... 76427@/home/corante/public_html/pipeline/ Business and Markets 2013-05-20T06:27:33-05:00 http://pipeline.corante.com/archives/2013/05/15/and_the_award_for_clinical_futility_goes_to_.php I was talking with someone the other day about the most difficult targets and therapeutic areas we knew, and that brought up the question: which of these has had the greatest number of clinical failures? Sepsis was my nomination: I... 76418@/home/corante/public_html/pipeline/ Clinical Trials 2013-05-15T13:51:40-05:00 http://pipeline.corante.com/archives/2013/04/23/ibm_and_the_limits_of_transferable_tech_expertise.php Here's a fine piece from Matthew Herper over at Forbes on an IBM/Roche collaboration in gene sequencing. IBM had an interesting technology platform in the area, which they modestly called the "DNA transistor". For a while, it was going to... 76363@/home/corante/public_html/pipeline/ Biological News 2013-04-23T11:21:34-05:00 http://pipeline.corante.com/archives/2013/04/03/astrazenecas_move_to_hot_happening_cambridge.php If you're looking for a sunny, optimistic take on AstraZeneca's move to Cambridge in the UK, the Telegraph has it for you right here. It's a rousing, bullish take on the whole Cambridge scene, but as John Carroll points out... 76322@/home/corante/public_html/pipeline/ Drug Industry History 2013-04-03T06:55:38-05:00 http://pipeline.corante.com/archives/2013/03/19/affymax_in_trouble.php Affymax has had a long history, and it's rarely been dull. The company was founded in 1988, back in the very earliest flush of the Combichem era, and in its early years it (along with Pharmacopeia) was what people thought... 76285@/home/corante/public_html/pipeline/ Business and Markets 2013-03-19T07:15:02-05:00 http://pipeline.corante.com/archives/2013/03/14/does_baldness_get_more_funding_than_malaria.php OK, let's fact-check Bill Gates today, shall we? Capitalism means that there is much more research into male baldness than there is into diseases such as malaria, which mostly affect poor people, said Bill Gates, speaking at the Royal Academy... 76278@/home/corante/public_html/pipeline/ Drug Development 2013-03-14T08:01:39-05:00 http://pipeline.corante.com/archives/2013/03/04/putting_the_hard_chemistry_back_in_med_chem.php While I'm on the subject of editorials, Takashi Tsukamoto of Johns Hopkins has one out in ACS Medicinal Chemistry Letters. Part of it is a follow-up to my own trumpet call in the journal last year (check the top of... 76251@/home/corante/public_html/pipeline/ Drug Industry History 2013-03-04T09:45:18-05:00 http://pipeline.corante.com/archives/2013/02/21/the_hard_targets_how_far_along_are_we.php I wrote here about whole classes of potential drug targets that we really don't know how to deal with. It's been several years since then, and I don't think that the situation has improved all that much. (In 2011 I... 76226@/home/corante/public_html/pipeline/ Drug Industry History 2013-02-21T10:04:04-05:00 http://pipeline.corante.com/archives/2013/01/25/cetp_alzheimers_monty_hall_and_roulette_and_goats.php CETP, now there's a drug target that has incinerated a lot of money over the years. Here's a roundup of compounds I posted on back last summer, with links to their brutal development histories. I wondered here about what's going... 76163@/home/corante/public_html/pipeline/ Alzheimer's Disease 2013-01-25T07:58:20-05:00 http://pipeline.corante.com/archives/2013/01/24/daniel_vasella_steps_down_at_novartis.php So Daniel Vasella, longtime chairman of Novartis, has announced that he's stepping down. (He'll be replaced by Joerg Reinhardt, ex-Bayer, who was at Novartis before that). Vasella's had a long run. People on the discovery side of the business will... 76160@/home/corante/public_html/pipeline/ Business and Markets 2013-01-24T07:53:33-05:00 http://pipeline.corante.com/archives/2012/12/03/marcia_angells_interview_i_just_cant.php I have tried to listen to this podcast with Marcia Angell, on drug companies and their research, but I cannot seem to make it all the way through. I start shouting at the screen, at the speakers, at the air... 76041@/home/corante/public_html/pipeline/ Why Everyone Loves Us 2012-12-03T11:22:57-05:00