/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-05-15T06:28:27-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/05/15/gsks_published_kinase_inhibitor_set.php Speaking about open-source drug discovery (such as it is) and sharing of data sets (such as they are), I really should mention a significant example in this area: the GSK Published Kinase Inhibitor Set. (It was mentioned in the comments... 76417@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2013-05-15T06:28:27-05:00 http://pipeline.corante.com/archives/2013/05/13/pyrrolidines_not_the_usual_way.php I wanted to mention a new reaction that's come out in a paper in Science. It's from the Betley lab at Harvard, and it's a new way to make densely substituted saturated nitrogen heterocycles (pyrrolidines, in particular). You start from... 76411@/home/corante/public_html/pipeline/ Chemical News 2013-05-13T10:18:15-05:00 http://pipeline.corante.com/archives/2013/05/08/total_synthesis_in_print.php Over at the Baran group's "Open Flask" blog, there's a post on the number of total synthesis papers that show up in the Journal of the American Chemical Society. I'm reproducing one of the figures below, the percentage of JACS... 76400@/home/corante/public_html/pipeline/ Chemical News 2013-05-08T09:57:00-05:00 http://pipeline.corante.com/archives/2013/04/26/the_portable_chemists_consultant.php I wanted to mention a project of Prof. Phil Baran of Scripps and his co-authors, Yoshihiro Ishihara and Ana Montero. It's called the Portable Chemist's Consultant, and it's available for iPads here. And here's a web-based look at its features.... 76369@/home/corante/public_html/pipeline/ Book Recommendations 2013-04-26T06:57:40-05:00 http://pipeline.corante.com/archives/2013/04/16/whats_translational_synthesis_anyway.php There's another paper in the Nature Chemical Biology special issue that I wanted to mention, this one on "Translational Synthetic Chemistry". I can't say that I like the title, which seems to me to have a problem with reification (the... 76346@/home/corante/public_html/pipeline/ Drug Assays 2013-04-16T22:05:24-05:00 http://pipeline.corante.com/archives/2013/04/14/how_to_deal_with_the_ridiculously_huge_universe_of_compounds.php Here's another look at the vast universe of things that no chemist has ever made. Estimates of the number of compounds with molecular weights under 500 run as high as ten to the sixtieth, which is an incomprehensibly huge number.... 76344@/home/corante/public_html/pipeline/ Chemical News 2013-04-14T21:26:38-05:00 http://pipeline.corante.com/archives/2013/04/12/ppar_delta_for_cycling_i_think_not.php Now here's one that I didn't know about: a reader sends along word that the former clinical candidate GW501516 is enjoying some popularity on the black market among cyclists and other athletes. I remember that compound well from the days... 76342@/home/corante/public_html/pipeline/ Chemical News 2013-04-12T07:51:51-05:00 http://pipeline.corante.com/archives/2013/04/09/new_sirtuin_inhibitors.php And since that last post was about sirtuins, here's a new paper in press at J. Med. Chem. from the Sirtris folks (or the Sirtris folks that were, depending on who's making the move down to PA). They report a... 76336@/home/corante/public_html/pipeline/ Aging and Lifespan 2013-04-09T12:06:04-05:00 http://pipeline.corante.com/archives/2013/04/05/chlorine_trifluoride_some_empirical_findings.php Over the years, I've probably had more hits on my "Sand Won't Save You This Time" post than on any other single one on the site. That details the fun you can have with chloride trifluoride, and believe me, it... 76328@/home/corante/public_html/pipeline/ Chemical News 2013-04-05T11:32:53-05:00 http://pipeline.corante.com/archives/2013/04/05/more_reaction_discovery.php The reaction discovery field continues to increase its throughput, on ever-smaller amounts of material. (That link has several previous discussions here imbedded in it). The latest report uses laser-assisted mass spec to analyze aliquots (less than a microliter each) of... 76327@/home/corante/public_html/pipeline/ Chemical News 2013-04-05T06:22:08-05:00 http://pipeline.corante.com/archives/2013/04/01/chembark_closing_down_update_not_really.php Looks like the long-running ChemBark blog is shutting down. Paul Bracher has a new academic position to get off the ground, a move to another part of the country, labs to set up, and grant applications to write, all of... 76316@/home/corante/public_html/pipeline/ Chemical News 2013-04-01T08:37:34-05:00 http://pipeline.corante.com/archives/2013/03/27/the_dnaencoded_library_platform_yields_a_hit.php I wrote here about DNA-barcoding of huge (massively, crazily huge) combichem libraries, a technology that apparently works, although one can think of a lot of reasons why it shouldn't. This is something that GlaxoSmithKline bought by acquiring Praecis some years... 76307@/home/corante/public_html/pipeline/ Chemical Biology 2013-03-27T10:47:18-05:00 http://pipeline.corante.com/archives/2013/03/26/automated_medchem_at_last.php I've written several times about flow chemistry here, and a new paper in J. Med. Chem. prompts me to return to the subject. This, though, is the next stage in flow chemistry - more like flow med-chem: Here, we report... 76305@/home/corante/public_html/pipeline/ Chemical News 2013-03-26T10:43:03-05:00 http://pipeline.corante.com/archives/2013/03/11/the_baran_group_blog_and_some_others.php I wanted to mention that Phil Baran's group at Scripps now has a blog, where group members are putting up posts on several topics, from recent syntheses to jelly beans. Well worth keeping an eye on. And I'd like to... 76269@/home/corante/public_html/pipeline/ Chemical News 2013-03-11T11:26:45-05:00 http://pipeline.corante.com/archives/2013/03/04/the_ibx_answer.php I wanted to point out what looks like the resolution of the Blog Syn story about IBX oxidations. See Arr Oh seems to have discovered the discrepancy that's been kicking the results around all over the place: water in the... 76252@/home/corante/public_html/pipeline/ Chemical News 2013-03-04T11:51:05-05:00