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About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
Not Voodoo

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
A New Merck, Reviewed
Liberal Arts Chemistry
Electron Pusher
All Things Metathesis
C&E News Blogs
Chemiotics II
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
BBSRC/Douglas Kell
Realizations in Biostatistics
ChemSpider Blog
Organic Chem - Education & Industry
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
The Curious Wavefunction
Natural Product Man
Fragment Literature
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Eye on FDA
Chemical Forums
Symyx Blog
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa

Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
Gene Expression (I)
Gene Expression (II)
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
Cosmic Variance
Biology News Net

Medical Blogs
DB's Medical Rants
Science-Based Medicine
Respectful Insolence
Diabetes Mine

Economics and Business
Marginal Revolution
The Volokh Conspiracy
Knowledge Problem

Politics / Current Events
Virginia Postrel
Belmont Club
Mickey Kaus

Belles Lettres
Uncouth Reflections
Arts and Letters Daily

In the Pipeline

Category Index
"Me Too" Drugs
The Hydrophobic Effect: I Don't Understand It, Either
Donald Light Responds on Drug Innovation and Costs
Getting Drug Research Really, Really Wrong
Translation Needed
Those Me-Too Drugs
Biosimilars: Not So Dang Easy
Pfizer's Future: Biotech Followups
Arzoxifene: Not the Road to Big Profits?
Now Your Liver Doesn't Have to Make It For You
How Many PPIs Does the World Need?
Bad Luck For Novartis - And For Diabetics
Godzilla vs. Mothra? Relman vs. Epstein!
By a Nose in a Head to Head
No Clear Winners
Gritting Our Teeth
An Economist Who Gets It
Alex Tabarrok on Me-Too Drugs
Blurry Copies
The Last Word (For A While) On Me-Too Drugs
Me Too, Part Two
Clinical Trials And What to Do With Them
Hypertension and Marketing
Merck and Its Competition
Our Buddies at the FDA
Adam Smith Goes Pharmaceutical
Innovation and Its Discontents
Claritin and Clarinex

Academia (vs. Industry)
Changing A Broken Science System
A Reply on Academic Alzheimer's Research
An All-In-One Alzheimer's Paper
The Seat of Learning, Indeed
Big Pharma And Its Research Publications
The NIH Takes On Reproducibility
The NIH's Drug Repurposing Program Gets Going
The Drug Industry and the Obama Administration
GSK's Published Kinase Inhibitor Set
Crowdfunding Research
The NIH, Pfizer, and Senator Wyden
Yuri Milner's Millions, And Where They're Going
Too Many Scientists: A "Pyramid Scheme"
Academia's Role in Drug Discovery
Advice For Those Trying High-Throughput Screening
Another Controversial Scaffold?
Rearrange Those Chemists
Science Fiction Gets the Upper Hand
Cheer For Good Ol' Pfizer U
Lessons For a New Medicinal Chemist
Return of the Rhodanome
Anonymous Grant Review Gets A Try
The NIH's Drug Repurposing Initiative: Will It Be a Waste?
A New Way to Kill Amoebas, From An Old Drug
A Molecular Craigslist?
Do Industrial Post-Doc Positions Work?
Different Worlds: A Last DHFR Paper Thought
Europe Wants Some of That Molecular Library Action
Merck's CALIBR Venture
Making the Move From Industry to Academia
More on the NIH's Molecular Libraries Program
That Academic-Industrial Collaboration Panel
Academia and Industry, Suing Each Other
Panel on Academic-Industrial Collaboration in Drug Discovery
Francis Collins Speaks
Does Anyone Want the NIH's Drug Screening Program?
"The Smarter You Are, The More I Will Hate You"
Publishing, Perishing, Buying and Selling
How Many New Drug Targets Aren't Even Real?
Broader Impacts Indeed
The NIH and Conflicts of Interest
What Translational Research Should Academia Do?
Academic Drug Discovery: A Survey
Roche Prevails Over Stanford
Maybe It Really Is That Hard?
Translation Needed
The PhD Problem: A Global Perspective
Nothing Personal
Roche and Stanford: Academia v. Industry?
What If Those Wonderful Results Are Wrong?
The NIH Goes For the Gusto
More On the Postdoc Situation
A Postdoc's Lament
Gonna Focus on Re-Engineering the Tools for the Process
New Cures! Faster! Faster!
The NIH's New Drug Discovery Center: Heading Into the Swamp?
Friday Mental Health Break: "Bad Project"
Chemistry Jobs Roundtable: What About Tenure?
Design Your Own Lab Course
And One Was Just Right?
Where Drugs Come From: By Country
Where Drugs Come From: The Numbers
Another Set of Eyes
A Pile of Malaria Leads For the Taking
Reasons Not to Go to Grad School?
All Of You Industrial Scientists: Out Of the Room
Fear Of Academic Chemistry?
Short Topics From All Over
I'll See Your Conflicts, and Raise You?
The Grant Application Treadmill
Industrial Research: More Grounded in Reality, or Not?
To What End?
Just Give It to NIH
Wasted Money, Wasted Time?
Where Drugs Come From, and How. Once More, With A Roll of the Eyes
More Hot Air From Me on Screening
Competing (And Competing Unethically?)
Poor Equipment Revisited
The Perils of Poor Equipment
More Than This
Lowe's Law of Diurnal Distribution
Getting To Lyrica
Scrape Off Some Attitude
Ugly, But Useful
Drugs From Where?
The Doctorate and Its Discontents
Naked Synthesis
What Can Academia Do?
Problems and Solutions
Peter Kim, So Far
Not On the Same Page
University of Drug Discovery?
The Great Divide
Mutual Suspicions
Differences Between Academia and Industry, Pt. 4
Sneaking Out for an Interview
Getting A Job
More on Question Four
Getting a Faster PhD?
The Bones of the World
Don't Become A Scientist?
Like Moving Furniture Across a Tightrope
Gumming Up the Amyloid Works
The NIH in the Clinic
One More On Basic Research and the Clinic
A Real-World Can O' Worms
How Much Basic Research?
How It Really Works
Will the Uncommon Work for the Common Good?
Industry vs. Academia: The Mental Aspect
Stuart Schreiber on Stuart Schreiber
Differences Between Academia and Industry, Pt. 2
Differences Between Industry and Academia, Pt. 1
On the Money

Aging and Lifespan
A Sirtuin Activator Extends Lifespan in Normal Mice
Boost Your NAD And Fix It All?
Google Versus Aging
A New Pathway For Memory
How Rapamycin Extends Lifespan: Not By Slowing Down Aging
Resveratrol: What's It Do For Mitochondria?
A New Book on Longevity Research
New Sirtuin Inhibitors
Resveratrol Gets Some Details Cleared Up
Caloric Restriction Flops?
Update on the Buckyball Longevity Paper
One More on That Buckyball Longevity Paper
Buckyball Longevity: The Lead Author Replies
Resveratrol Explained. A Little Bit.
Buckyball Longevity - There's A Problem
Buckyballs Prolong Life? Really?
Would I Take Resveratrol? Would You?
Defending Das' Resvertrol Research. Oh, Come On.
A Resveratrol Research Scandal. Oh, Joy.
The Sirtuin Saga
Resveratrol in Humans: Results of a Controlled Trial
The Latest Sirtuin Controversy
Big Sirtuin News
SRT1720: Good (And Confusing) News for Obese Mice
mINDY Mice - No Obesity, No Diabetes?
Live Long and Prosper (and Be Bright Yellow at the Same Time)
Resveratrol (SRT501): Development Halted
Dapsone Prolongs Life? Well, In Nematodes It Does. . .
Does Resveratrol Really Work? And Does SRT1720?
GSK's Response to the Sirtuin Critics
Resveratrol (SRT501): Buy Now - Why Wait?
The Memory Goes Because. . .the Acetyl Groups Go?
SRT501 - A Trial Suspended
The Scent of Food Is Enough?
Sirtris's Compounds: Everyone Agrees?
Take These?
Rapamycin for Alzheimer's?
The Problem With Research on Aging
BioTime's Cellular Aging Results
A GSK/Sirtris Wrap-Up
A Storm in a Teacup
GSK and Sirtris: A Bit More
Sirtuin Scenarios
The Sirtris Compounds: Worthless? Really?
Caloric Restriction and Lifespan - Without the Caloric Restriction?
What Exactly Does Resveratrol Do?
A Nobel for Telomerase
mTOR, Rapamycin, and Lifespan: A Startling Study
Exercise and Vitamins: Now, Wait A Minute. . .
Resveratrol in Mice
Why Buy, Anyway?
$720 Million Worth of Sirtuin Research
Breaking the Contract of Aging
More Sirtuins With More Effects
And Thee, O Time
Sir2 Surprise
Klotho: Sooner Than You Think?
Breathing and Aging
When Natural Selection's Through With You - Part II
After Natural Selection's Through With You

Alzheimer's Disease
The State of Alzheimer's Research, 2014
A Blood Test for Alzheimer's?
Alzheimer's Therapies: A Reasonably Gloomy Update
A Reply on Academic Alzheimer's Research
An All-In-One Alzheimer's Paper
David Cameron, The Press, Alzheimer's, and Hope
Lilly Goes All In on Solanezumab
A Beta-Secretase Inhibitor Hits the Skids in Alzheimer's
Update on Bexarotene for Alzheimer's
The FDA's New Alzheimer's Guidance: Wonder or Blunder?
TauRx's Funding Is Odd
CETP, Alzheimer's, Monty Hall, and Roulette. And Goats.
Eli Lilly's Brave Alzheimer's Talk
Merck Presses Ahead on Alzheimer's:
TauRx Goes Into Phase III For Alzheimer's
And Since We're Talking About Insider Trading
JNK3 - Something New for Alzheimer's?
The Coming Battle Over Alzheimer's Disease
Another Prospective Alzheimer's Trial
Lilly's Solanezumab: Did It Actually Work?
Lilly's Solanezumab: A Miss or a Win?
Bapineuzumab Still Does Not Work Against Alzheimer's
An Alzheimer's Update: Amyloid Lives?
Bapineuzumab Does Not Work Against Alzheimer's
Live By The Bricks, Die By The Bricks
Strangely Good Results in Diabetes and Cardiovascular Disease
A Preventative Trial for Alzheimer's: The Right Experiment
Bapineuzumab: An Alzheimer's Update
Bexarotene for Alzheimer's
Tau Spreads On Its Own?
Bernard Munos Rides Again
Alzheimer's: The News Is Not Getting Better
Alzheimer's: Down With Amyloid?
Lilly's Gamma Secretase Inhibitor for Alzheimer's: Worse Than Nothing
Alzheimer's Markers and Collaboration
Alzheimer's and Amyloid, Again
Alzheimer's: Extracting Data From Failed Trials
The Memory Goes Because. . .the Acetyl Groups Go?
A Brief and Not At All Intemperate Evaluation of the Current Literature
Rapamycin for Alzheimer's?
Beta-Amyloid: An Antibiotic?
Dimebon, Grasping at Straws
Dimebon Comes Crashing to Earth
A Modest Literature Proposal
Dimebon for Alzheimer's: A Black Box Indeed
Two Doses of Crazy
An Alzheimer's Compound Runs Into Big Trouble
Short Topics From All Over
Amyloid in Trouble
Does Glucophage Make Alzheimer's Worse?
Short Items: India, Sanjay Gupta, Satori Pharmaceuticals
Where Are the Drugs?
Rember for Alzheimer's: Methylene Blue's Comeback
Bapineuzumab: Good For Anything or Not?
Patents Stopping an Alzheimer's Wonder Drug?
Another Alzheimer's Compound Goes Down
Protecting Amyloid's Parent?
Elan Tries Again
In Which I Hate A Wonder Drug
Alzheimer's: A Report From the Front
ApoE4: Test or Not?
Fast Plaques in a Slow Disease
Checking The Numbers on the Alzheimer's Test
Beta-Secretase: Not So Fast?
Failure: Not Your Friend, But Definitely Your Companion
How Good Is Aricept, Anyway?
A Trial Too Far
Gumming Up the Amyloid Works
Silent Mutations and Noisy Ones
Back on the Air
Alzheimer's Vaccine Refuses to Die
Sleeping Dragons
Maybe They Can Formulate It in Madelaines
Who Dares, Wins?
Modeling the Brain?

Analytical Chemistry
A New NMR Probe Technology in the Making?
A New Way to Get Protein Crystal Structures
Crystallography Without Crystallizing: An Update
Ligands From Nothing
An HIV Structure Breakthrough? Or "Complete Rubbish"?
The 3D Fragment Consortium
New Frontiers in Analytical Chemistry
Touching Up the Spectra
Picking Out Incorrect Natural Products
GPCRs Are As Crazy As You Thought
Watching DNA Polymerase Do Its Thing
Check Out These Molecules
Underappreciated Analytical Techniques
IBM And The Limits of Transferable Tech Expertise
Mass Spec Continues Its Conquests
X-Ray Structures Of Everything. Without Crystals. Holy Cow.
Probing A Binding Tunnel With AFM
Single-Cell NMR? How About Single-Protein NMR?
Stanford's Free Electron Laser Blasts Away
Every Tiny Detail
Picosecond Protein Watching
GSK's Anti-Doping Ad
Bungled Structure, And How
Fluorine NMR: Why Not?
An NMR Poster
Proteins in a Living Cell
Fishing Around for Biomarkers
XMRV: It's Ugly, But That's Science
Detecting Single Cancer Cells
NASA's Arsenic Bacteria: A Call For Follow-Up Experiments
Enthalpy and Entropy Again
The Latest Technology
Chemical Biology: Plastic Antibodies?
Wisterone: A Structure I Can't Believe
Chemical Biology - The Future?
Running Your Fingers Over A Single Molecule
Floyd Landis: The Isotopes Weren't Lying, After All
Masses of Data, In Every Sample
Calorimetry: What Say You?
Sequenom: Strike Up the Music, Bring On the Cream Pies
The Infinitely Active Impurity
Sure About That?
Run It Past the Chemists
GE Healthcare's Idiotic Libel Suit
Faking X-Ray Structures. . .For Fun? Or Profit? Or What?
Water and Proteins Inside Cells: Sloshing Around, Or Not?
More Binding Site Weirdness
A Nobel for Ribosome Structure
Tie Me Molecule Down, Sport
The Great Acetonitrile Shortage
More Glowing Cells: Chemistry Comes Through Again
You Call That An X-Ray Source?
X-Ray Structures: Handle With Care
Start Small, Start Right
These Fragments I Have Shored Against My Ruins
Mass Spec on Mars
Floyd Landis: Could His Cortisone Treatments Exonerate Him?
Testosterone, Carbon Isotopes, and Floyd Landis
Doublets, Triplets, Whateverlets
Medicine Man

Animal Testing
A Call For Better Mouse Studies
Lab Mice Are Being Kept Too Cold, Apparently
Of Mice (Studies) and Men
Mouse Models of Inflammation Are Basically Worthless. Now We Know.
Lab Animals Wiped Out in Hurricane Sandy
The Mouse Trap
Reboxetine Doesn't Work. But That's Not the Real Problem.
Cancer Cells: Too Unstable For Fine Targeting?
Charles River Buys WuXi
Animal Studies: Are Too Many Never Published At All?
Fat Rats Make Poor Test Subjects?
Animal Testing: A View From the Labs
Animal Rights, You Say?
Animal Models: How High to Set the Bar?
Whose Guess Is Better?
The Animal Testing Hierarchy
Less Than Zero
Worst Animal Model: Nominations Are Open
Formally Undecideable
Rats Rule, Right?
Ends, Means, Rats, and Dogs
Model Systems, From Inside and Out
Furry Judges, With Tails
What to Do When the Rats Die on You
Rats, For Fear of Worse
You'll Only Get Answers
Modeling the Brain?

More Vaccine Fearmongering
What Autism Epidemic?
MMR Vaccine and Autism: Lies, All Lies
Vaccines in the Court
Autism and Vaccines: Boiling Over Yet Again
Thimerosal. Again.
Thimerosal, Again
A Mechanism for Thimerosal
Here and There
Compare and Contrast
The Rate of Autism
Clearance Sale
Thimerosal - A Chemical Point
Thimerosal - a Chemical Point
Clearance Sale
A Quick Tour Through the Mudhole
More on Autism (And Mercury)
More on Autism and Mercury
A Quick Tour Through the Mudhole
Doing Justice to Thimerosal, And the Story
Doing Justice to Thimerosal, and the Story

Biological News
More on the Science Chemogenomic Signatures Paper
A Huntington's Breakthrough?
Another Target Validation Effort
Google's Big Data Flu Flop
Years Worth of the Stuff
Stem Cell Shakedown Cruise
A Close Look at Receptor Signaling
Ces3 (Ces1) Inhibition As a Drug Target
Not Again - Stem Cell Results in Trouble?
"It Is Not Hard to Peddle Incoherent Math to Biologists"
A Timeline from Cell
Irisin and Metabolism - A New Target Emerges
The Evidence Piles Up: Antioxidant Supplements Are Bad For You
The Return of Gene Therapy (And More)
Antivirals: "I Love the Deviousness of It All"
Trouble With Stapled Peptides? A Strong Rebuttal.
Boost Your NAD And Fix It All?
Cancer Cell Line Assays: You Won't Like Hearing This
Fred Sanger, 1918-2013
It Doesn't Repeat? Who's Interested?
Rewriting History at the Smithsonian?
Allosteric Binding Illuminated?
The 2013 Medicine/Physiology Nobel: Traffic
The Arguing Over PTC124 and Duchenne Muscular Dystrophy
More on Warp Drive Bio and Cryptic Natural Products
CRISPR Takes Off
GPCRs As Drug Targets: Nowhere Near Played Out
An HIV Structure Breakthrough? Or "Complete Rubbish"?
Another T-Cell Advance Against Cancer
Knockout Mice, In Detail
The Junk DNA Wars Get Hotter
More From Warp Drive Bio (And Less From Aileron?)
Corroboration for ENCODE?
GPCRs Are As Crazy As You Thought
Watching DNA Polymerase Do Its Thing
How Many Binding Pockets Are There?
GSK's Published Kinase Inhibitor Set
Another Big Genome Disparity (With Bonus ENCODE Bashing)
What The Heck Does "Epigenetic" Mean, Anyway?
IBM And The Limits of Transferable Tech Expertise
Pseudoenzymes: Back From the Dead as Targets?
Super-Enhancers in Cell Biology: ENCODE's Revenge?
Good News in Oncology: More Immune Therapy for Leukemia
AstraZeneca Makes a Deal With Moderna. Wait, Who?
More ENCODE Skepticism
Probing A Binding Tunnel With AFM
ENCODE: The Nastiest Dissent I've Seen in Quite Some Time
Mouse Models of Inflammation Are Basically Worthless. Now We Know.
Do We Really Know the Cause for Over 4500 Diseases?
Farewell to Bioinformatics
Is Obesity An Infectious Disease?
Another Reactive Oxygen Paper
Reactive Oxygen Species Are Your Friends!
The Last Thing a Professor Wants to Hear
Sue the Nobel Committee. Yeah, That'll Work.
Picosecond Protein Watching
The 2012 Nobel In Chemistry. Yes, Chemistry.
ENCODE And What It All Means
Databases and Money
Just How Do Enzymes Work?
Public Domain Databases in Medicinal Chemistry
Biomarker Caution
Europe Wants Some of That Molecular Library Action
Ciliobrevins: Digging Into Cell Biology
The Ultimate in Personalized Medicine
Roche Goes Hostile for Illumina
Fun With Epigenetics
Warp Drive Bio: Best Name or Worst?
Osiris And Their Stem Cells
Brain Cells: Different From Each Other, But Similar to Something Else?
Proteins in a Living Cell
Geron, Stem-Cell Pioneers, Drop Stem Cells
Cyclodextrin's Day in the Sun
The Latest Sirtuin Controversy
Big Sirtuin News
Merck, RNAi, Alnylam, And So On
Bait And Switch For Type B GPCRs
A First Step Toward A New Form of Life
The Histamine Code, You Say?
The Uses of Disorder
Garage Biotech: The Book
Biomarkers, Revisited. Unfortunately.
Get Yer Telomeres Measured, Step Right Up
Smell The Vibrations? Fruit Flies Might Be Able To. . .
Fishing Around for Biomarkers
Arsenic Bacteria: Does The Evidence Hold Up?
Roche Has Problems - But RNA Interference Has More
And Now, the Retractome
Epigenetics: The Code Isn't The Object
TRIM21: A Cure For the Common Cold? Maybe Not. . .
Are Genes Patentable Or Not?
Laser Nematode Surgery!
More on Garage Biotech
Chemical Biology: Engineering Enzymes
Chemical Biology - The Future?
Vinca Alkaloids, And Where They End Up
Reverse-Engineering the Human Brain? Really?
Maybe We Should Make It More of a Game
Craig Venter, Venting
XMRV and Chronic Fatigue: You Thought You Were Confused Before
Stable Helical Peptides Can Do It All?
A Synthetic Genome; A New Species
Curse of the Plastic Tubes
The Scent of Food Is Enough?
Homemade Morphine?
Masses of Data, In Every Sample
Let's Sequence These Guys
ACC2: Great Metabolic Target, Or Total Bust?
Rapamycin for Alzheimer's?
Sickened by an Engineered Virus?
What Do Nanoparticles Really Look Like?
GeneVec's Pancreatic Cancer Therapy Crashes
Nanoparticles and RNA: Now In Humans
A Bit More Garage Biotech
BioTime's Cellular Aging Results
Stem Cell Politics
The PSA Test for Prostate Cancer: Useless
Garage Biotech
A GSK/Sirtris Wrap-Up
Your Own Personal Bacteria
The Plasmid Committee Will See You Now
Biology By the Numbers
Enzymes and Fluorines
Receptors, Moving and Shaking
Maybe You Need Some More Testosterone Over There
An Enzyme Inhibitor You Have Never, Ever, Considered
Correlations, Lovely Correlations
MAGL: A New Cancer Target
Is XMRV the Cause of Chronic Fatigue Syndrome? Or Anything?
Extortion, Retractions, And More
Five Technologies For the Scrap Heap?
Run It Past the Chemists
Water and Proteins Inside Cells: Sloshing Around, Or Not?
What Exactly Does Resveratrol Do?
Nanotech Armor
Engineering Receptors: Not Quite There Yet. Not Exactly.
A Nobel for Ribosome Structure
A Nobel for Telomerase
Antioxidants and Cancer: Backwards?
Right Where You Want Them
Still Semaphoring, Even From the Bottom of the Swimming Pool
Schematic Notation for Biology?
Dealing With Hedgehog Screening Results
What's So Special About Ribose?
Genzyme's Virus Problems
Exercise and Vitamins: Now, Wait A Minute. . .
Niacin, No Longer Red-Faced?
No MAGIC Involved
Genes to Diseases: Hard Work, You Say?
The Motions of a Protein
Grabbing Onto A Protein's Surface
Gene Expression: You Haven't Been Thinking Big Enough?
Wash Your Tubes; Mess Up Your Data
System Biology: Ready, or Not?
Fructose In The Brain?
More Glowing Cells: Chemistry Comes Through Again
A Green Fluorescent Nobel Prize
Antipsychotics: Do They Work For A Completely Different Reason?
New, Improved DNA?
Receptors: Can't Live With 'Em, Can't Understand 'Em
Killing Proteins Wholesale
Empty As Can Be
Nanotech Stem Cells, Order Now!
RNA Interference: Even Trickier Than You Thought
Getting Real With Real Cells
Rainbows and Fishing Expeditions
Avandia: Going Under for the Third Time?
A Real Genetic Headscratcher
What We Don't Know About Enzymes
Checking The Numbers on the Alzheimer's Test
Let Us Now Turn To the Example of Yo' Mama
More Things Than Are Dreamt Of
Visfatin: Real Or Not?
It Went Up Instead of Down
Peptides as Texts
Neowater Replies
Nanotech Wonder Water?
Stem Cell Disaster
Grand Rounds Today, and Next Week
RNAi: The Awkward Age
Kinases and Their Komplications
The Vapor Trail I Referred To
It's a Bacterial Planet, You Know
There'd Better Not Be an Argon Receptor
All Bets Are Now Officially Off
A New Cancer Target - Maybe
Gene Therapy Decisions

Birth of an Idea
Open Source Science?
Vial Thirty-Three, And More
Back on the Air
Vial Thirty-Three: Warp Drive
The Race Is On
Publish, Then Perish
The Horse Latitudes
Good News, Now That I Think About It!
Back To Life
Vial Thirty-Three: The Third Run
Vial Thirty-Three Rides Again
Vial Thirty-Three: One Up, One Down
Mid-day Update
Minute by Minute
Vial Number Thirty-Three
Cliff Diving
A Scientist's Resolutions
Report From What I Think is the Frontier
Experimental News
News Flash: I May Not Be a Fool
Data, At Last
Experimental Update
Experimental Update, For Those Who Care
Live The Stereotype!
The Consolations of Pure Research
Don't Talk To Yourself So Much
Mismatched Socks
A Little Ambiguity Would Be Welcome Right About Now
Dr. Lowe? I Have Your Hypothesis on Line Two
If This Doesn't Work, There's Only Reality To Fall Back On
Good News, Backing Slowly Through the Door?
Waiting for the Metaphorical Phone to Ring
Per Fits and Starts, Ad Astra
Here It Goes
Nature Stood Me Up
Close to the Vest
Close To the Vest
Experimental Update
In Case Anyone's Wondering
Back for More
Meanwhile, Back at the Chocolate Factory
The Nuts and Bolts of a New Idea
Measure Twice, Cut Once

Blink ›
Nature Doesn't Care: Latest in a Series
Vaccines by the Dozen
Follow Which Money Where?
An Experiment in Progress?
Alex Tabarrok on Me-Too Drugs

Blog Housekeeping
Days Off
Off To the Publishers
A Quick Clean-Up
For Some Folks, It's New Year's Day
Traveling Interruption
Out to Illinois
ACS Webinars on Drug Discovery
Back Blogging (Bonus Biographical Begging)
Cold-Weather Chicken Soup
Russian Soured Cabbage
Thanksgiving: Never Trust An Organic Chemist Who Can't Cook
Things People Won't Listen To?
Chemist At Work
Chemistry Job Postings: Worth a Try
Back to Hendrix
Travel (Back to Arkansas)
Cambridge Meetup Final Plans: Noon by Broad Canal Way
Cambridge "In the Pipeline" Reader Meetup: October 10
An "In the Pipeline" Meetup in Cambridge?
A War On Expertise?
A Quick Recipe: Lime Sorbet
Totally Off Topic: My Appearance on Jeopardy!
A Chemical Biology Conference
Comment Troubles
A Fourth of July Recipe: Pork Tenderloin and Sour Onion Salsa
A Quick Traffic Update
Travel and Upcoming Posts
New Photos, Same Blather
Best Sites for a Medicinal Chemist?
Travel (University of Wisconsin)
Not the Usual Morning Around Here
Traffic and More Traffic
A Malfunctioning Spambot
Quick E-mail Housekeeping Note
Off Topic: Happy New Year, In March
An Interview
Snow Versus Scientific Progress
A Traffic Record
Another Recipe: Cornbread
A Bean Soup Recipe, With Bonus Country Ham Talk, And a Cameo By Frederick the Great
A Christmas Break
Chemistry Software Questions Answered Monday
Thanksgiving Synthesis
Back On the Air
Blogging Outage
Travel (For C&E News)
Conference Travel
R. B. Woodward Does Furnish A Room
Drew University Visit
More Details
Day Off
Shortage of Blogification
Comments (And Everything Else) Are Back
Comment Trouble
Ten Years of Science Blogging. Already?
Media Note
Holiday Break
Blog Traffic: A Thank-You
A "Things I Won't Work With" Request
Happy Thanksgiving
Lab Preparation: Key Lime Pie
Conference Travel, With Blogging
Day Off - Some Links and Some Ancient Greek
What An Offer
Back to Blogging
On and Off
Memorial Day
Inadvertent Day Off
Conference Time
Day Off
Another Snow Day
Snow and Chance Happeneth To Them All
Another Cold-Weather Recipe: Chicken Pot Pie
A Cold-Weather Recipe, By Request: Onion Soup
Weather Delay
Holiday Break
Blogging Break
Holiday Organic Synthesis: Chocolate Pecan Pie
Open Thread
Day Off
Blogroll Update
Housekeeping Note
Lunch at the Boston ACS Meeting
By The Way. . .
Out in the Public
Back in Business
More From the Fourth
Nativis: In Which the Distant Footfalls of Lawyers Can Be Heard
Coming Soon
Chemistry In (Ahem) Everyday Life
Delivery Via Kindle
Of Cambridge, MA Interest Only
More on C&E News
Day Off
More Blogroll
Blogroll Update
Blog Traffic - Thanks!
Write A Book, Why Don't You
Twitter and Science, Revisited
Sure Thing
Physics, for Dogs and Others
Holiday Time Off
Day Off!
Another Blogroll Update
Light Blogging
Applied Organic Synthesis: Chocolate Pecan Pie
More For the Blogroll
A Blogroll Update
"Back to School"
Day Off
Traveling, Updates Later
Traffic Record
Time to Sing the Alma Mater
H-h-h-holy C-c-c-c-cow
Blogroll Update
Return From Travel: A Note About Cheaptickets.com
Travel Continues. . .
Day Off
Blogroll Update
Proxy Server Update
Proxies for Iran (More Politics - Mixed With Technology)
And Now Some Politics
Quick Blogroll Update
Blog Contestification
Blog Contestiness
A Science Writing Award
Still More Blogroll Additions
Blogroll Update
More Travel!
San Diego
Blogs and Journalism
Hexacyclinol - Another Request
Day Off
The Blogroll
Holiday Break
How Slow is Research Today? Here's a Recipe!
Day Off
Time Off
Happy Fourth of July
Leaving Comments: A Fix
Explaining It All
Quick Note
Day Off
Commenting Issues
Back On the Air
Snow Day
Synthetic Prep of the Day: Chocolate Pecan Pie
Holiday Break
Bright Lights and Applause?
Blogroll Update
Meet the Blogger?
Not Necessarily So
Two Weeks Off
Real Life, Which Costs Real Money
But Enough About You
Blogroll Update
Back From DC
You Want Me to Just Talk? No Problem.
Comments on Comments
Blogroll Update
Back on the Air
Work At Home! It's Easy; It's Fun!
Holiday Schedule
Shameless Self-Promotion
Watch This Space
Links and Such
Darn Photons
Here and There
A Friday Linkfest
Back on the Air
Missed One!
A Lengthy Day
Technical Difficulties
Blogroll Revamp
Various Updates
Comments Welcome - Really
Instead of Working
Procrastination Assistance
Outside Reading, and Plenty of It
And Another Thing. . .
Blogging About Science Blogging
Even More Worthwhile Stuff
Like, Er, Fine Wine. I Hope.
Summer Hours
Continued Slacking
Outside Reading
New Address
One Problem Solved, Anyway
A Technical Question
And Now A Word. . .
Schedule Update
Holiday Blogging
Stocking Stuffers, of a Sort
Now With The Great Taste of Fish
Comment Problems
Two Days Off (From This, Anyway)
No Coming Attractions Here
A Question For the Audience
Summer Hours
The Last Word on Taste
Welcome Back!
Catching Up
Here and There

Book Recommendations
A New Book
Holiday Blogging
Science Gifts: Running Experiments at Home
The Chemistry Book
E. O. Wilson's "Letters to a Young Scientist"
The Portable Chemist's Consultant
A New Book on Longevity Research
Two New Books
Science Gifts: Actual Med-Chem Books
Brain Cells: Different From Each Other, But Similar to Something Else?
A New Book on Chemical Patents
Data Handling in Collaborations
Book Review: The Quest for the Cure
Garage Biotech: The Book
Drug Discovery History
Serendipity in Medicine
Friday Book Recommendation
Friday Book Recommendation
A Friday Book Recommendation
Physics, for Dogs and Others
Recommended Books For Medicinal Chemists, Part One
Business Books: The Enantiomers
A Med-Chem Book Recommendation
Inspirational Reading?

Business and Markets
Shuffling the Departments
Pfizer Walks Again By Night
Novartis Gets Out of RNAi
AstraZeneca's Cambridge Move
Biotech Boom, Biotech Bust?
Outsourcing Everything
GSK Dismisses Employees in Bribery Scandal. Apparently.
Reality-Based Biotech Investing
Where The Hot Drugs Come From: Somewhere Else
A Look Back at Big Pharma Stocks
Another Whack at the Stem Shortage Myth
Always Insist on Error Bars
Startups vs. Big Pharma
Biggest US Cities for Biopharma Funding, Versus Whole Continents.
Novartis's Stealthy Headcount Reductions
A Bit More Realism in Consulting
The Instructive Case of Galena Biopharma
InterMune Comes Through
Big Drug Mergers: So They're OK, Right?
Jobs, He Says
Drug Discovery in India
How the New BioPharma IPOs Have Been Doing
Crowdfunding Independent Research
AstraZeneca Cutting Back - Some More
Overqualified For the Job
Novartis Does A Big, Quiet Reshuffle
How Not to Invest in Biopharma
AstraZeneca Closes a Lab - In India This Time
What STEM Shortage? Where? How?
Novartis Continues Closing and Rearranging
Abandoning the Chinese Drug Market
"We Had to Clear Out Some Chemists"
A Short Guide to the JP Morgan Conference
Alnylam Makes It (As Does RNAi?)
The 2013 Drug Approvals: Not So Great?
Grading the Drug Companies
Bristol-Myers Squibb Exits Diabetes
A Look Under the VC Hood For 2013
GlaxoSmithKline's New Sales Practices
A Year-End Review at Xconomy
Eye of the Beholder Stuff
Worst Biotech CEO Time
Drug Companies In Great Britain: Ease Up, Won't You?
Eisai Cuts Back
The Freshness Index
Cuts at Shire
Layoffs and Personal Finance
No More Stack Ranking at Microsoft
The Other Shoe Drops at Ariad
Exiting Two Therapeutic Areas
Now Novartis-Emeryville?
BMS Reshuffling