/home/corante/public_html/pipeline/ en-us derek-lowe@sbcglobal.net 2008-09-19T07:54:05-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2008/09/19/sunesis_no_substitutions_allowed.php A colleague mentioned to me the other day that Sunesis Pharmaceuticals had let many of its remaining research staff go back during the summer – they’re battening down to try to get their main clinical candidate through for leukemia and... 73544@/home/corante/public_html/pipeline/ Drug Industry History 2008-09-19T07:54:05-05:00 http://pipeline.corante.com/archives/2008/09/12/bms_vs_imclone_godzilla_exchanges_legal_language_with_mothra.php I haven’t mentioned the attempt by Bristol-Meyers Squibb to buy out Imclone until now, but there’s a nice . The reasons for the move are unsurprising – BMS would like all the revenue from Erbitux, instead of just a share... 73536@/home/corante/public_html/pipeline/ Business and Markets 2008-09-12T07:41:15-05:00 http://pipeline.corante.com/archives/2008/09/08/the_complicated_causes_of_cancer.php Since I was just banging on the table (or the lab bench) the other day about how many diseases aren’t single-factor, and about how many diseases (like cancer) aren’t even single diseases, I thought this would be a good time... 73532@/home/corante/public_html/pipeline/ Cancer 2008-09-08T07:31:38-05:00 http://pipeline.corante.com/archives/2008/08/01/gsk_layoffs_yes_again.php The ax is falling again at GlaxoSmithKline. This time it’s the oncology group. Last month the cardiovascular people got this same treatment, you’ll recall, and there was some disagreement about how many jobs were being affected. But it looks like... 73479@/home/corante/public_html/pipeline/ Cancer 2008-08-01T07:24:07-05:00 http://pipeline.corante.com/archives/2008/07/22/vytorin_another_round_of_nasty_results.php Merck took the unusual step of delaying its earnings release yesterday until after the close of the market. A report on another clinical study of Vytorin (ezetimibe), their drug with Schering-Plough, was coming out, so they put the numbers on... 73455@/home/corante/public_html/pipeline/ Cardiovascular Disease 2008-07-22T08:08:24-05:00 http://pipeline.corante.com/archives/2008/06/23/auroral_activity.php If you go to the med-chem or pharmacology literature databases and type "Aurora kinase", you'd better stand back. A geyser of publications will come spraying out, most of them having to do with Aurora A and/or Aurora B as possible... 73387@/home/corante/public_html/pipeline/ Cancer 2008-06-23T07:28:32-05:00 http://pipeline.corante.com/archives/2008/04/09/and_you_thought_exubera_was_a_disaster_before.php I don't usually do more than one post a day, but this really caught my eye. In an ongoing review of Pfizer's (now discontinued) inhaled insulin (Exubera), an increased chance of lung cancer has turned up among participants in the... 73218@/home/corante/public_html/pipeline/ Diabetes and Obesity 2008-04-09T10:35:32-05:00 http://pipeline.corante.com/archives/2008/04/03/whose_guess_is_better.php I was having a discussion the other day about which therapeutic areas have the best predictive assays. That is, what diseases can you be reasonably sure of treating before your drug candidate gets into (costly) human trials? As we went... 73209@/home/corante/public_html/pipeline/ Animal Testing 2008-04-03T07:19:01-05:00 http://pipeline.corante.com/archives/2008/01/16/judah_folkman.php So Judah Folkman is no longer with us. He's considered to be the father of the idea that many tumors help to make their own blood supply, through angiogenesis, and that this could be a way to impede their growth.... 73027@/home/corante/public_html/pipeline/ Cancer 2008-01-16T08:20:07-05:00 http://pipeline.corante.com/archives/2008/01/04/plants_for_cancer.php A reader sends along this article from the New York Times about Chris Kilham, an ethnobiotanist from U. Mass - Amherst looking for medicinally active plants in Peru. The article has lots of local Peruvian color, but it doesn’t neglect... 72986@/home/corante/public_html/pipeline/ Cancer 2008-01-04T09:23:34-05:00 http://pipeline.corante.com/archives/2007/10/29/bacterial_infection_better_or_worse_than_cancer.php There’s been a steady stream of reports in the news about methacillin-resistant Staph. aureus. It’s not a new problem, but (like other nasty infections) it does get a lot of press when the media start paying attention. Works in reverse,... 72810@/home/corante/public_html/pipeline/ Infectious Diseases 2007-10-29T07:33:13-05:00 http://pipeline.corante.com/archives/2007/09/17/arsenic_patents_and_the_world.php As I was mentioning the other day, the latest issue of Nature Medicine has the details on a story that doesn’t, on the face of it, do the industry any credit. About twenty years ago, there were reports out of... 72681@/home/corante/public_html/pipeline/ 2007-09-17T08:25:59-05:00 http://pipeline.corante.com/archives/2007/08/20/the_current_cancer_longjump_record.php As I've mentioned before, advances in molecular biology have continued to make all sorts of brute-force approachs possible - things that would have been laughed at (or, more likely, not even proposed at all) a few years ago. Another recent... 72611@/home/corante/public_html/pipeline/ Cancer 2007-08-20T06:38:47-05:00 http://pipeline.corante.com/archives/2007/06/04/phase_zero.php We have a new phrase to toss around in in the industry: "Phase Zero". That's what they're calling a recent trial of an anticancer drug from Abbott (ABT-888), which was tested in humans before any safety dosing (Phase I) had... 72367@/home/corante/public_html/pipeline/ Clinical Trials 2007-06-04T20:46:33-05:00 http://pipeline.corante.com/archives/2007/04/19/let_a_thousand_flowers_bloom.php If you want to see a bunch of press releases from biotech companies that you've never, ever heard of in your life, just go over to Google News and type in "AACR", sorting by date. That meeting just wound up,... 72235@/home/corante/public_html/pipeline/ Cancer 2007-04-19T09:43:58-05:00