/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-04-23T11:21:34-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/04/23/ibm_and_the_limits_of_transferable_tech_expertise.php Here's a fine piece from Matthew Herper over at Forbes on an IBM/Roche collaboration in gene sequencing. IBM had an interesting technology platform in the area, which they modestly called the "DNA transistor". For a while, it was going to... 76363@/home/corante/public_html/pipeline/ Biological News 2013-04-23T11:21:34-05:00 http://pipeline.corante.com/archives/2013/04/09/mass_spec_continues_its_conquests.php You know, mass spectrometry has been gradually taking over the world. Well, maybe not your world, but mine (and that of a lot of biopharma/biophysical researchers). There are just so many things that you can do with modern instrumentation that... 76335@/home/corante/public_html/pipeline/ Analytical Chemistry 2013-04-09T07:08:43-05:00 http://pipeline.corante.com/archives/2013/03/28/xray_structures_of_everything_without_crystals_holy_cow.php There's an absolutely startling new paper out from Makoto Fujita and co-workers at the University of Tokyo. I've written a number of times here about X-ray crystallography, which can be the most powerful tool available for solving the structures of... 76309@/home/corante/public_html/pipeline/ Analytical Chemistry 2013-03-28T07:03:48-05:00 http://pipeline.corante.com/archives/2013/03/07/probing_a_binding_tunnel_with_afm.php Every so often I've mentioned some of the work being done with atomic force microscopy (AFM), and how it might apply to medicinal chemistry. It's been used to confirm a natural product structural assignment, and then there are images like... 76263@/home/corante/public_html/pipeline/ Biological News 2013-03-07T07:25:46-05:00 http://pipeline.corante.com/archives/2013/02/04/singlecell_nmr_how_about_singleprotein_nmr.php Two different research teams have reported a completely different way to run NMR experiments, one that looks like it could take the resolution down to cellular (or even large protein) levels. These two papers in Science have the details (and... 76187@/home/corante/public_html/pipeline/ Analytical Chemistry 2013-02-04T11:05:38-05:00 http://pipeline.corante.com/archives/2012/12/03/stanfords_free_electron_laser_blasts_away.php Here's another next-generation X-ray crystal paper, this time using a free electron laser X-ray source. That's powerful enough to cause very fast and significant radiation damage to any crystals you put in its way, so the team used a flow... 76039@/home/corante/public_html/pipeline/ Chemical News 2012-12-03T09:05:32-05:00 http://pipeline.corante.com/archives/2012/11/28/every_tiny_detail.php Via Chemjobber, we have here an excellent example of how much detail you have to get into if you're seriously making a drug for the market. When you have to account for every impurity, and come up with procedures that... 76030@/home/corante/public_html/pipeline/ Chemical News 2012-11-28T13:33:20-05:00 http://pipeline.corante.com/archives/2012/11/08/picosecond_protein_watching.php We're getting closer to real-time X-ray structures of protein function, and I think I speak for a lot of chemists and biologists when I say that this has been a longstanding dream. X-ray structures, when they work well, can give... 75986@/home/corante/public_html/pipeline/ Biological News 2012-11-08T08:23:17-05:00 http://pipeline.corante.com/archives/2012/08/07/gsks_antidoping_ad.php Courtesy of a reader in the UK, here's an ad from GlaxoSmithKline that I don't think has been seen much on this side of the Atlantic. I hadn't realized that they were involved in the drug testing for the... 75794@/home/corante/public_html/pipeline/ General Scientific News 2012-08-07T07:11:29-05:00 http://pipeline.corante.com/archives/2012/06/27/bungled_structure_and_how.php A lot of natural product structures have been misassigned over the years. In the old days, it was a wonder when you were able to assign a complex one at all. Structure determination, pre-NMR, could be an intellectual challenge at... 75725@/home/corante/public_html/pipeline/ Chemical News 2012-06-27T06:53:09-05:00 http://pipeline.corante.com/archives/2012/02/02/fluorine_nmr_why_not.php Fluorine NMR is underused in chemistry. Well, then again, maybe it's not, but it's one of those thing that just seems like it should have more uses than it does. (Here's a recent bookon the subject). Fluorine is a great... 75424@/home/corante/public_html/pipeline/ Analytical Chemistry 2012-02-02T11:50:37-05:00 http://pipeline.corante.com/archives/2011/12/14/an_nmr_poster.php Here's a very nice poster-style presentation of proton NMR and spectral interpretation, courtesy of Jon Chui. I wish I'd had something like it when I was learning the topic, and it's a very useful way to picture it even for... 75329@/home/corante/public_html/pipeline/ Analytical Chemistry 2011-12-14T13:15:22-05:00 http://pipeline.corante.com/archives/2011/11/16/proteins_in_a_living_cell.php It's messy inside a cell. The closer we look, the more seems to be going on. And now there's a closer look than ever at the state of proteins inside a common human cell line, and it does nothing but... 75276@/home/corante/public_html/pipeline/ Biological News 2011-11-16T07:31:36-05:00 http://pipeline.corante.com/archives/2011/01/14/fishing_around_for_biomarkers.php Everyone in this industry wants to have good, predictive biomarkers for human diseases. We've wanted that for a very long time, though, and in most cases, we're still waiting. [For those outside the field, a biomarker is some sort of... 74827@/home/corante/public_html/pipeline/ Analytical Chemistry 2011-01-14T07:58:24-05:00 http://pipeline.corante.com/archives/2011/01/11/xmrv_its_ugly_but_thats_science.php How's the XMRV / chronic fatigue syndrome connection holding up? Not real well. Science has a roundup of the latest news in the area, and none of it looks encouraging. There are four studies that have come out in the... 74820@/home/corante/public_html/pipeline/ Infectious Diseases 2011-01-11T08:29:56-05:00