/home/corante/public_html/pipeline/ en-us derek-lowe@sbcglobal.net 2008-03-27T07:30:02-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2008/03/27/start_small_start_right.php There’s an excellent paper in the most recent issue of Chemistry and Biology that illustrates some of what fragment-based drug discovery is all about. The authors (the van Aalten group at Dundee) are looking at a known inhibitor of the... 73187@/home/corante/public_html/pipeline/ In Silico 2008-03-27T07:30:02-05:00 http://pipeline.corante.com/archives/2008/01/22/these_fragments_i_have_shored_against_my_ruins.php There’s been a big trend the last few years in the industry to try to build our molecules up from much smaller pieces than usual. “Fragment-based” drug discovery is the subject of many conferences and review articles these days, and... 73042@/home/corante/public_html/pipeline/ Drug Assays 2008-01-22T09:23:08-05:00 http://pipeline.corante.com/archives/2006/10/25/mass_spec_on_mars.php There's an interesting analytical chemistry paper in the preprint section of PNAS (open access if you want to read it) that may reopen an old controversy. It's from a large multinational team (Mexico, Spain, France, NASA-Ames) investigating the GC-mass spec... 68035@/home/corante/public_html/pipeline/ Life As We (Don't) Know It 2006-10-25T21:19:35-05:00 http://pipeline.corante.com/archives/2006/08/27/floyd_landis_could_his_cortisone_treatments_exonerate_him.php After my article on the role of carbon isotope testing in the Floyd Landis case, a question has come up several times in the comments and in my e-mail: since it's well-known that Landis was taking cortisone for his hip,... 64447@/home/corante/public_html/pipeline/ Current Events 2006-08-27T16:36:34-05:00 http://pipeline.corante.com/archives/2006/08/01/testosterone_carbon_isotopes_and_floyd_landis.php The New York Times broke the story today that the testosterone found in Tour de France champion Floyd Landis's blood was not from a natural source. Just how do they know that, and how reliable is the test? The first... 62964@/home/corante/public_html/pipeline/ Current Events 2006-08-01T21:00:41-05:00 http://pipeline.corante.com/archives/2004/06/03/doublets_triplets_whateverlets.php Another day spent rooting around in the archives, trying to appease the rapacious Taiwanese patent office. One more day should about do it, and not a moment too soon. I'm now unearthing NMR spectral data for compounds, and translating those... 10978@/home/corante/public_html/pipeline/ Patents and IP 2004-06-03T21:44:46-05:00 http://pipeline.corante.com/archives/2002/02/01/medicine_man.php I can't talk about rain forest drug discovery without mentioning the (pretty bad) 1992 Sean Connery movie Medicine Man. He plays an alleged biochemist who comes up with a Miracle Drug, more or less by finding it under a leaf.Plenty... 10650@/home/corante/public_html/pipeline/ Analytical Chemistry 2002-02-01T21:03:04-05:00