/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2012-02-02T11:50:37-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2012/02/02/fluorine_nmr_why_not.php Fluorine NMR is underused in chemistry. Well, then again, maybe it's not, but it's one of those thing that just seems like it should have more uses than it does. (Here's a recent bookon the subject). Fluorine is a great... 75424@/home/corante/public_html/pipeline/ Analytical Chemistry 2012-02-02T11:50:37-05:00 http://pipeline.corante.com/archives/2011/12/14/an_nmr_poster.php Here's a very nice poster-style presentation of proton NMR and spectral interpretation, courtesy of Jon Chui. I wish I'd had something like it when I was learning the topic, and it's a very useful way to picture it even for... 75329@/home/corante/public_html/pipeline/ Analytical Chemistry 2011-12-14T13:15:22-05:00 http://pipeline.corante.com/archives/2011/11/16/proteins_in_a_living_cell.php It's messy inside a cell. The closer we look, the more seems to be going on. And now there's a closer look than ever at the state of proteins inside a common human cell line, and it does nothing but... 75276@/home/corante/public_html/pipeline/ Biological News 2011-11-16T07:31:36-05:00 http://pipeline.corante.com/archives/2011/01/14/fishing_around_for_biomarkers.php Everyone in this industry wants to have good, predictive biomarkers for human diseases. We've wanted that for a very long time, though, and in most cases, we're still waiting. [For those outside the field, a biomarker is some sort of... 74827@/home/corante/public_html/pipeline/ Analytical Chemistry 2011-01-14T07:58:24-05:00 http://pipeline.corante.com/archives/2011/01/11/xmrv_its_ugly_but_thats_science.php How's the XMRV / chronic fatigue syndrome connection holding up? Not real well. Science has a roundup of the latest news in the area, and none of it looks encouraging. There are four studies that have come out in the... 74820@/home/corante/public_html/pipeline/ Infectious Diseases 2011-01-11T08:29:56-05:00 http://pipeline.corante.com/archives/2011/01/04/detecting_single_cancer_cells.php This story on a new diagnostic method in oncology is getting a lot of attention in the press. It's a collaboration between J&J, a small company they've bought called Veridex, and several oncology centers to see if very sensitive monitoring... 74809@/home/corante/public_html/pipeline/ Cancer 2011-01-04T09:33:12-05:00 http://pipeline.corante.com/archives/2010/12/08/nasas_arsenic_bacteria_a_call_for_followup_experiments.php Since the posts here on the possible arsenic-using bacteria have generated so many comments, I'd like to try to bring things together. If you think that the NASA results need shoring up - and a lot of people do, including... 74787@/home/corante/public_html/pipeline/ Analytical Chemistry 2010-12-08T14:59:10-05:00 http://pipeline.corante.com/archives/2010/10/26/enthalpy_and_entropy_again.php Earlier this year, I wrote here about using calorimetry in drug discovery. Years ago, people would have given you the raised eyebrow if you'd suggested that, but it's gradually becoming more popular, especially among people doing fragment-based drug discovery. After... 74734@/home/corante/public_html/pipeline/ Life in the Drug Labs 2010-10-26T07:10:56-05:00 http://pipeline.corante.com/archives/2010/10/22/the_latest_technology.php Well, the latest for 1960, anyway. That's the Bruker KIS-1 NMR machine there, folks, operating at 25 MHZ, and ready to dim the lights in the whole building when you switch on that electromagnet. Allow about 12 hours of acquisition... 74729@/home/corante/public_html/pipeline/ Analytical Chemistry 2010-10-22T10:35:28-05:00 http://pipeline.corante.com/archives/2010/10/05/chemical_biology_plastic_antibodies.php Here's an interesting example of a way that synthetic chemistry is creeping into the provinces of molecular biology. There have been a lot of interesting ideas over the years around the idea of polymers made to recognize other molecules. These... 74696@/home/corante/public_html/pipeline/ Chemical News 2010-10-05T07:55:46-05:00 http://pipeline.corante.com/archives/2010/09/28/wisterone_a_structure_i_cant_believe.php You don't see an awful lot of chemistry publications from Vietnam. So in a way, I'm reluctant to call attention to this one, in the way that I'm about to. But it's in the preprint section of Bioorganic and Medicinal... 74689@/home/corante/public_html/pipeline/ Chemical News 2010-09-28T10:06:53-05:00 http://pipeline.corante.com/archives/2010/09/23/chemical_biology_the_future.php I agree with many of the commenters around here that one of the most interesting and productive research frontiers in organic chemistry is where it runs into molecular biology. There are so many extraordinary tools that have been left lying... 74680@/home/corante/public_html/pipeline/ Biological News 2010-09-23T07:38:01-05:00 http://pipeline.corante.com/archives/2010/08/04/running_your_fingers_over_a_single_molecule.php Readers will remember the extraordinary pictures of individual pentacene molecules last fall. Well, the same IBM team, working with a group at Aberdeen, has struck again. This time they've imaged a much more complex organic molecule, cephalandole A. As that... 74609@/home/corante/public_html/pipeline/ Analytical Chemistry 2010-08-04T10:02:19-05:00 http://pipeline.corante.com/archives/2010/05/20/floyd_landis_the_isotopes_werent_lying_after_all.php This post from 2006 on the science behind Floyd Landis's suspicious steroid blood tests set my blog record for comments - the debate went on and on about Landis, about the lab that reported the results, about how the samples... 74481@/home/corante/public_html/pipeline/ Analytical Chemistry 2010-05-20T11:07:45-05:00 http://pipeline.corante.com/archives/2010/04/27/masses_of_data_in_every_sample.php I've said several times that I think that mass spectrometry is taking over the analytical world, and there's more evidence of that in Angewandte Chemie. A group at Justus Liebig University in Giessen has built what has to be the... 74425@/home/corante/public_html/pipeline/ Analytical Chemistry 2010-04-27T06:17:52-05:00