/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-03-25T10:51:25-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/03/25/the_fdas_new_alzheimers_guidance_wonder_or_blunder.php You can get either answer, depending on whom you ask. Last month, the agency unveiled new guidelines for developing Alzheimer's therapies. They're trying to deal with the difficulty of showing actual cognitive improvement in more advanced patients, while at the... 76302@/home/corante/public_html/pipeline/ Alzheimer's Disease 2013-03-25T10:51:25-05:00 http://pipeline.corante.com/archives/2013/03/05/taurxs_funding_is_odd.php I still get inquiries about TauRx and their work on Alzheimer's. There's an awful lot of pent-up demand in that field, and it's getting worse every year. The latest is that the company has ten million more dollars in a... 76257@/home/corante/public_html/pipeline/ Business and Markets 2013-03-05T13:37:05-05:00 http://pipeline.corante.com/archives/2013/01/25/cetp_alzheimers_monty_hall_and_roulette_and_goats.php CETP, now there's a drug target that has incinerated a lot of money over the years. Here's a roundup of compounds I posted on back last summer, with links to their brutal development histories. I wondered here about what's going... 76163@/home/corante/public_html/pipeline/ Alzheimer's Disease 2013-01-25T07:58:20-05:00 http://pipeline.corante.com/archives/2012/12/12/eli_lillys_brave_alzheimers_talk.php I'm a bit baffled by Eli Lilly's strategy on Alzheimer's. Not the scientific side of it - they're going strongly after the amyloid hypothesis, with secretase inhibitors and antibody therapies, and if I were committed to the amyloid hypothesis, that's... 76065@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-12-12T07:14:41-05:00 http://pipeline.corante.com/archives/2012/12/04/merck_presses_ahead_on_alzheimers.php One Alzheimer's compound recently died off in the clinic - Bristol-Myers Squibb's avagacestat, a gamma-secretase inhibitor, has been pulled from trials. The compound "did not establish a profile that supported advancement" to Phase III, says the company. Gamma-secretase has been... 76043@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-12-04T07:27:02-05:00 http://pipeline.corante.com/archives/2012/11/21/taurx_goes_into_phase_iii_for_alzheimers.php I can't even count the number of e-mails I've gotten over the last few years asking about TauRx and their Alzheimer's program, which made a big splash back in 2008. Finally, there's some news to report. The company is starting... 76017@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-11-21T09:10:20-05:00 http://pipeline.corante.com/archives/2012/11/20/and_since_were_talking_about_insider_trading.php Here's something from just this morning, a whopping large case on illegal trading in Wyeth and Elan stock. This one involves a hedge fund manager, Mathew Martoma, and (quite disturbingly), Dr. Sidney Gilman of the University of Michigan, who was... 76014@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-11-20T11:30:50-05:00 http://pipeline.corante.com/archives/2012/11/09/jnk3_something_new_for_alzheimers.php There's been an interesting recent development in the biology of Alzheimer's disease. c-Jun N-terminal kinase 3 (JNK3, known to those in the field, semi-affectionately, as "Junk-Three") is expressed mostly in the CNS, and has been implicated as a player in... 75989@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-11-09T07:48:07-05:00 http://pipeline.corante.com/archives/2012/10/31/the_coming_battle_over_alzheimers_disease.php Solanezumab is a story that won't go away. Eli Lilly's antibody therapy for Alzheimer's is the subject of a lot of arguing among investors: some people (and I'm one of them) think that there is no strong evidence for its... 75973@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-10-31T06:57:47-05:00 http://pipeline.corante.com/archives/2012/10/12/another_prospective_alzheimers_trial.php I wrote here about a prospective Alzheimer's trial that's starting soon among a population in Colombia, and now comes word of another large effort along the same lines. DIAN, the Dominantly Inherited Alzheimer's Network, will test several current Alzheimer's candidates... 75927@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-10-12T06:30:20-05:00 http://pipeline.corante.com/archives/2012/10/09/lillys_solanezumab_did_it_actually_work.php "Hope Rises For Alzheimer's Treatment, Scientists Say". Not this scientist. That's a composite of headlines, but it captures the unfortunate tone. We're talking about solanezumab, Eli Lilly's antibody therapy. The company presented analysis of their trial data yesterday, and put... 75919@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-10-09T06:13:05-05:00 http://pipeline.corante.com/archives/2012/08/24/lillys_solanezumab_a_miss_or_a_win.php Lilly has reported results from its anti-amyloid antibody, solanezumab, and. . .well, it's mixed. And it's either quite good news, or quite bad. You make the call. The therapy missed its endpoints (both "cognitive and functional", according to the company)... 75834@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-08-24T10:20:12-05:00 http://pipeline.corante.com/archives/2012/08/07/bapineuzumab_still_does_not_work_against_alzheimers.php As expected (by all but the most relentlessly optimistic observers), the anti-Alzheimers antibody bapineuzumab has now failed in its most likely patient population. Results came out last night about from patients who do not carry the ApoE4 mutation, the only... 75795@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-08-07T07:26:46-05:00 http://pipeline.corante.com/archives/2012/07/26/an_alzheimers_update_amyloid_lives.php There's a good state-of-the-field post over at Chemiotics on Alzheimer's, in the wake of the bapineuzumab news the other day. Of particular interest is the recent finding by deCODE and Genentech researchers that there's a mutation in the Alzheimer's precursor... 75775@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-07-26T10:45:26-05:00 http://pipeline.corante.com/archives/2012/07/24/bapineuzumab_does_not_work_against_alzheimers.php This long, long story may finally be coming to an end. Immune-based therapies against beta-amyloid (and the associated amyloid plaques) have been in development for many years now (an excellent review here), and Elan has been in the thick of... 75769@/home/corante/public_html/pipeline/ Alzheimer's Disease 2012-07-24T07:45:24-05:00