/home/corante/public_html/pipeline/ en-us derek-lowe@sbcglobal.net 2008-06-06T07:38:59-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2008/06/06/resveratrol_in_mice.php Since it’s a favorite topic of mine, I really have to point out this study in PLoS ONE on resveratrol. A large collaboration looked at the gene transcription effects of dosing the compound in mice, compared to a normal diet... 73352@/home/corante/public_html/pipeline/ Aging and Lifespan 2008-06-06T07:38:59-05:00 http://pipeline.corante.com/archives/2008/04/25/why_buy_anyway.php I don’t want to say that this is a trend, but I notice that GSK is saying that they’re going to leave Sirtris more or less alone as well (as Takeda has said they’ll do with Millennium). The researchers in... 73254@/home/corante/public_html/pipeline/ Business and Markets 2008-04-25T07:47:23-05:00 http://pipeline.corante.com/archives/2008/04/24/720_million_worth_of_sirtuin_research.php Well, I’m back from a brief vacation, and catching up with the news. It looks like the big headline is GlaxoSmithKline’s offer for Sirtris: $720 million, which is a hefty premium (84%!) to what the company was trading for previously.... 73253@/home/corante/public_html/pipeline/ Business and Markets 2008-04-24T08:47:50-05:00 http://pipeline.corante.com/archives/2008/01/21/breaking_the_contract_of_aging.php Update: Prof. de Grey responds to Jim Hu's criticisms below I didn’t note it at the time here, but back in November there was a very interesting paper in Nature that bears on aging and life extension. A group at... 73041@/home/corante/public_html/pipeline/ Aging and Lifespan 2008-01-21T08:17:44-05:00 http://pipeline.corante.com/archives/2007/09/24/more_sirtuins_with_more_effects.php It’s been a while since I talked about sirtuins, but the field has not been quiet. The latest data is a paper in Cell which set off a strong move in the stock of Sirtris, the company closely tied to... 72709@/home/corante/public_html/pipeline/ Aging and Lifespan 2007-09-24T19:51:30-05:00 http://pipeline.corante.com/archives/2006/11/01/and_thee_o_time.php Back in 2003, I wrote about the paper that identified the natural product resveratrol as an activator of the sirtuin deacetylase pathway. This may well be the common thread between a host of studies on life-extending genes in model organisms... 68428@/home/corante/public_html/pipeline/ Aging and Lifespan 2006-11-01T23:04:23-05:00 http://pipeline.corante.com/archives/2005/11/20/sir2_surprise.php I've written before about the gene known as SIR2. Overexpression of it (or its homologs in different animals) extends lifespan in a range of organisms, and there's been a tremendous amount of research on these over the last few years.... 38242@/home/corante/public_html/pipeline/ Aging and Lifespan 2005-11-20T10:40:14-05:00 http://pipeline.corante.com/archives/2005/09/19/klotho_sooner_than_you_think.php There's been a lot of news in the aging-research area about the Klotho gene (and its associated protein) the last few years. Now there's a recent paper in Science that is bringing it back into the spotlight. I won't go... 11305@/home/corante/public_html/pipeline/ Aging and Lifespan 2005-09-19T20:58:49-05:00 http://pipeline.corante.com/archives/2002/08/01/breathing_and_aging.php I've written about the idea that aging is related to oxidative damage (most recently on June 3.) There's a lot of support for it, and the documented life-extending properties of caloric restriction are thought by many to be tied into... 10732@/home/corante/public_html/pipeline/ Aging and Lifespan 2002-08-01T21:49:06-05:00 http://pipeline.corante.com/archives/2002/06/03/when_natural_selections_through_with_you_part_ii.php Another useful paper (Science 296, 1276) has come out on the mechanisms of aging. Ever since the 1950s, the idea of accumulating free radical damage has been a strong contender, to the point that it's been absorbed into popular culture.... 10700@/home/corante/public_html/pipeline/ Aging and Lifespan 2002-06-03T21:44:57-05:00 http://pipeline.corante.com/archives/2002/05/14/after_natural_selections_through_with_you.php There's an interesting article on aging in the latest issue of Current Biology. The researchers used gene-chip assays, which look at over 13,000 genes simultaneously for signs of up- or down-regulation, in populations of aging fruit flies.Fruit flies share a... 10688@/home/corante/public_html/pipeline/ Aging and Lifespan 2002-05-14T21:42:08-05:00