/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-04-24T12:32:25-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/04/24/a_new_book_on_longevity_research.php The University of Chicago Press has sent along a copy of a new book by DePaul professor Ted Anton, The Longevity Seekers. It's a history of the last thirty years or so of advances in understanding the biochemical pathways of... 76365@/home/corante/public_html/pipeline/ Aging and Lifespan 2013-04-24T12:32:25-05:00 http://pipeline.corante.com/archives/2013/04/09/new_sirtuin_inhibitors.php And since that last post was about sirtuins, here's a new paper in press at J. Med. Chem. from the Sirtris folks (or the Sirtris folks that were, depending on who's making the move down to PA). They report a... 76336@/home/corante/public_html/pipeline/ Aging and Lifespan 2013-04-09T12:06:04-05:00 http://pipeline.corante.com/archives/2013/03/12/resveratrol_gets_some_details_cleared_up.php I've been meaning to write on this paper, from David Sinclair and co-workers, on the mechanism of resveratrol action. The backstory is so long and convoluted that you're going to have to set aside some time to catch up if... 76271@/home/corante/public_html/pipeline/ Aging and Lifespan 2013-03-12T06:59:46-05:00 http://pipeline.corante.com/archives/2012/08/29/caloric_restriction_flops.php Nature is out today with a paper on the results of a calorie-restriction study that began in 1987. This one took place with rhesus monkeys at the National Institute of Aging, and I'll skip right to the big result: no... 75839@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-08-29T13:17:50-05:00 http://pipeline.corante.com/archives/2012/06/28/update_on_the_buckyball_longevity_paper.php You'll remember the life-extending fullerenes paper that I blogged about here, and the various problems with it that sharp-eyed readers here spotted. (These drew comments from the lead author here and here). Now the journal has issued a correction that... 75728@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-06-28T11:40:13-05:00 http://pipeline.corante.com/archives/2012/05/09/one_more_on_that_buckyball_longevity_paper.php I've received another e-mail from Prof. Fathi Moussa, lead author of the C60 longevity paper that's been discussed around here. I'd sent a list of the critiques that had shown up in the comments sections, and here's the reply: An... 75625@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-05-09T11:27:16-05:00 http://pipeline.corante.com/archives/2012/05/08/buckyball_longevity_the_lead_author_replies.php I've received a reply from Dr. Fathi Moussa at Université Paris-Sud, lead author of the C60 longevity paper that I blogged about here, which turned out to have a duplicated figure. With permission, here are the main points of the... 75621@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-05-08T06:18:47-05:00 http://pipeline.corante.com/archives/2012/05/02/resveratrol_explained_a_little_bit.php There's a new paper out in Cell Metabolism on resveratrol and SIRT1, and the press release from Elsevier (Cell Press) is just a tiny bit optimistic. "Study resolves controversy on life-extending red wine ingredient, restores hope for anti-aging pill", says... 75607@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-05-02T06:16:17-05:00 http://pipeline.corante.com/archives/2012/04/20/buckyball_longevity_theres_a_problem.php We have a problem here. The paper I blogged about yesterday, on life extension effects with C60 fullerene ("buckyballs") has a duplicated figure. This was first spotted by commenter "Flatland" yesterday. I was traveling all day, and when I came... 75582@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-04-20T08:34:19-05:00 http://pipeline.corante.com/archives/2012/04/18/buckyballs_prolong_life_really.php I'm really, really not sure what to make of this paper (PDF). It's from a team that was studying the long-term toxicology of C60 (fullerene, "buckyballs") by giving them to rats as a solution in olive oil. The control groups... 75580@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-04-18T21:47:12-05:00 http://pipeline.corante.com/archives/2012/04/09/would_i_take_resveratrol_would_you.php I've written many times here about sirtuins, and their most famous associated small molecule, resveratrol. And I've been asked more than once by people outside the med-chem field if I take (or would take) resveratrol, given the available evidence. My... 75563@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-04-09T07:05:48-05:00 http://pipeline.corante.com/archives/2012/01/16/defending_das_resvertrol_research_oh_come_on.php I'm getting all the press releases from Bill Sardi, of Resveratrol Partners, as he does damage control from the Das scandal at UConn. And I have to say, he's putting in the hours getting these together. Problem is, on some... 75379@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-01-16T08:34:46-05:00 http://pipeline.corante.com/archives/2012/01/12/a_resveratrol_research_scandal_oh_joy.php My inbox has exploded with the story that many reports on the effects of resveratrol appear to be fraudulent. Prof. Dipak Das of Connecticut is at the center of what looks like a huge research stink bomb, which is being... 75374@/home/corante/public_html/pipeline/ Aging and Lifespan 2012-01-12T12:05:12-05:00 http://pipeline.corante.com/archives/2011/12/13/the_sirtuin_saga.php Science has a long article detailing the problems that have developed over the last few years in the whole siturin story. That's a process that I've been following here as well (scrolling through this category archive will give you the... 75325@/home/corante/public_html/pipeline/ Aging and Lifespan 2011-12-13T09:19:40-05:00 http://pipeline.corante.com/archives/2011/11/10/resveratrol_in_humans_results_of_a_controlled_trial.php The effects of resveratrol have been controversial, to say the least. Arguments rage about whether (and how) it affects the various sirtuin pathways, what those various sirtuin pathways are and what they do, and what the compound does in animal... 75267@/home/corante/public_html/pipeline/ Aging and Lifespan 2011-11-10T09:58:56-05:00