/home/corante/public_html/pipeline/ en-us derek-lowe@sbcglobal.net 2008-09-22T07:24:39-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2008/09/22/more_than_this.php Science is taking a look at the 1991 members of Yale’s Molecular Biology and Biophysics PhD program. The ostensible focus of the article is to see what the effect of flat federal research funding has been on young potential faculty... 73546@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2008-09-22T07:24:39-05:00 http://pipeline.corante.com/archives/2008/07/18/lowes_law_of_diurnal_distribution.php Here’s an appropriate topic for a Friday, although at first many of you may think I’ve lost my mind. What would happen if you combed the full text of the experimental sections of the chemistry journals, looking for how long... 73448@/home/corante/public_html/pipeline/ Life in the Drug Labs 2008-07-18T07:22:46-05:00 http://pipeline.corante.com/archives/2008/03/25/getting_to_lyrica.php There’s an interesting article in Angewandte Chemie by Richard Silverman of Northwestern, on the discovery of Lyrica (pregabalin). It’s a rare example of a compound that came right out of academia to become a drug, but the rest of its... 73181@/home/corante/public_html/pipeline/ Drug Development 2008-03-25T07:19:17-05:00 http://pipeline.corante.com/archives/2007/12/19/scrape_off_some_attitude.php There is a pecking order in chemistry. That’s because there’s one everywhere. If it’s a human endeavor, staffed by humans, you’re going to have hierarchies, real and perceived - who you did a post-doc with, what huge company you're a... 72958@/home/corante/public_html/pipeline/ Graduate School 2007-12-19T06:56:37-05:00 http://pipeline.corante.com/archives/2007/09/18/ugly_but_useful.php I also mentioned recently that I’d come across a good example of an academic compound with interesting activity but no chance of being a drug. Try this one out, from Organic Letters. Yes, there aren’t many other compounds that do... 72683@/home/corante/public_html/pipeline/ Patents and IP 2007-09-18T07:27:51-05:00 http://pipeline.corante.com/archives/2007/09/12/drugs_from_where.php The mention of tropical diseases here the other day turns out to be timely, since the latest Nature has several articles on various ways for industry and academia to partner on attacking these. Some adjustments are needed every time you... 72678@/home/corante/public_html/pipeline/ Drug Development 2007-09-12T20:27:11-05:00 http://pipeline.corante.com/archives/2007/04/17/the_doctorate_and_its_discontents.php The doctorate-or-not discussion is roaring along in the comments to the last post, and they're well worth reading. I have a few more thoughts on the subject myself, but I'm going to turn off comments to this post and ask... 72223@/home/corante/public_html/pipeline/ Graduate School 2007-04-17T11:15:17-05:00 http://pipeline.corante.com/archives/2007/03/23/naked_synthesis.php There's an unusual article in Nature that several folks have e-mailed me about. It's unusual for several reasons. For one thing, it's synthetic organic chemistry, and there's not much of that in Nature at all - it's an interesting choice... 72163@/home/corante/public_html/pipeline/ 2007-03-23T09:22:58-05:00 http://pipeline.corante.com/archives/2007/01/28/what_can_academia_do.php So, as reader CalProf asked in a comment the other day, what should academic scientists who want to help discover drugs be doing? As a first approximation, I'd say not drug discovery. That sounds a bit strange, I know, but... 71946@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2007-01-28T20:34:47-05:00 http://pipeline.corante.com/archives/2007/01/14/problems_and_solutions.php I had some e-mail from a graduate student in a good lab the other day, and I thought the questions raised were worth a blog post. He wrote: One thing which stands out to me is your enthusiasm for chemistry,... 71726@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2007-01-14T21:22:06-05:00 http://pipeline.corante.com/archives/2006/06/08/peter_kim_so_far.php There's an article in Wednesday's Wall Street Journal (subscriber-only link here) (Update: also available freely here - thanks to Kyle of The Chemblog for finding this) on Merck's head of research, Peter Kim. It's well-written, in the sense that depending... 59742@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2006-06-08T19:51:29-05:00 http://pipeline.corante.com/archives/2005/12/04/not_on_the_same_page.php I mentioned phosphatase inhibitors while talking about okadaic acid the other day, and that brings me to a paper from the journal ChemBioChem (6, 1749) that I was recently reading. It's a collaboration from six German academic groups, led by... 39449@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2005-12-04T20:42:31-05:00 http://pipeline.corante.com/archives/2005/11/08/university_of_drug_discovery.php There's an interesting letter to Science in the latest issue (Nov. 4, #5749, p. 777), in response to their special section on drug discovery in the July 29th issue. Adrian Ivinson, a former editor of Nature Medicine and now head... 37751@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2005-11-08T21:55:53-05:00 http://pipeline.corante.com/archives/2005/10/06/the_great_divide.php A reader at a large research university sends this along for comment: "My advisor is a staunch skeptic of the value of "big pharma". He recently made a comment in a group meeting that "Merck has not discovered anything in... 36867@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2005-10-06T12:07:24-05:00 http://pipeline.corante.com/archives/2005/08/22/mutual_suspicions.php I'm not saying these are all true, or true all the time. But here are three things that industrial pharma researchers tend to believe about academic ones: 1. They talk too darn much. Don't even think about sharing any proprietary... 11284@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2005-08-22T21:23:41-05:00