/home/corante/public_html/pipeline/ en-us derekb.lowe@gmail.com 2013-05-15T06:28:27-05:00 hourly 1 2000-01-01T12:00+00:00 http://pipeline.corante.com/archives/2013/05/15/gsks_published_kinase_inhibitor_set.php Speaking about open-source drug discovery (such as it is) and sharing of data sets (such as they are), I really should mention a significant example in this area: the GSK Published Kinase Inhibitor Set. (It was mentioned in the comments... 76417@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2013-05-15T06:28:27-05:00 http://pipeline.corante.com/archives/2013/05/14/crowdfunding_research.php Crowdfunding academic research might be changing, from a near-stunt to an widely used method of filling gaps in a research group's money supply. At least, that's the impression this article at Nature Jobs gives: The practice has exploded in recent... 76414@/home/corante/public_html/pipeline/ Business and Markets 2013-05-14T07:09:26-05:00 http://pipeline.corante.com/archives/2013/03/27/the_nih_pfizer_and_senator_wyden.php Senator Ron Wyden (D-Oregon) seems to be the latest champion of the "NIH discovers drugs and Pharma rips them off" viewpoint. Here's a post from John LaMattina on Wyden's recent letter to Francis Collins. The proximate cause of all this... 76306@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2013-03-27T06:50:28-05:00 http://pipeline.corante.com/archives/2013/03/01/yuri_milners_millions_and_where_theyre_going.php You'll have heard about Yuri Milner, the Russian entrepreneur (early Facebook investor, etc.) who's recently announced some rather generous research prize awards: Yesterday, Milner, along with some “old friends”—Google cofounder Sergey Brin, Facebook CEO Mark Zuckerberg, and their respective wives—announced... 76247@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2013-03-01T07:35:11-05:00 http://pipeline.corante.com/archives/2013/01/24/too_many_scientists_a_pyramid_scheme.php Chemistry World has really touched a lot of nerves with this editorial by economics professor Paula Stephan. It starts off with a look back to the beginnings of the NIH and NSF, Vannevar Bush's "Endless Frontier": . . .a goal... 76162@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2013-01-24T11:39:19-05:00 http://pipeline.corante.com/archives/2013/01/22/academias_role_in_drug_discovery.php There's a new Viewpoint piece out in ACS Medicinal Chemistry Letters on academia and drug discovery. Donna Huryn of Pittsburgh is wondering about the wisdom of trying to reproduce a drug-company environment inside a university: However, rather than asking how... 76154@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2013-01-22T12:02:17-05:00 http://pipeline.corante.com/archives/2012/11/28/advice_for_those_trying_highthroughput_screening.php So here's a question that a lot of people around here will have strong opinions on. I've heard from someone in an academic group that's looking into doing some high-throughput screening. As they put it, they don't want to end... 76028@/home/corante/public_html/pipeline/ Drug Assays 2012-11-28T09:50:21-05:00 http://pipeline.corante.com/archives/2012/10/19/another_controversial_scaffold.php My post the other day on a very unattractive screening hit/tool compound prompted a reader to mention this paper. It's one from industry this time (AstraZeneca), and at first it looks like similarly foul chemical matter. But I think it's... 75946@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-10-19T07:12:33-05:00 http://pipeline.corante.com/archives/2012/09/18/rearrange_those_chemists.php See Ahr Oh has a handy map of all the big recent faculty moves in the organic chemistry world, to help you keep up. Note that Nicolaou-to-Rice is still a dotted line.... 75869@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-09-18T06:19:30-05:00 http://pipeline.corante.com/archives/2012/07/23/science_fiction_gets_the_upper_hand.php I wrote here about the Cronin lab at Glasgow and their work on using 3-D printing technology to make small chemical reactors. Now there's an article on this research in the Observer that's getting some press attention (several people have... 75765@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-07-23T07:58:07-05:00 http://pipeline.corante.com/archives/2012/06/15/cheer_for_good_ol_pfizer_u.php The biggest pharma companies increasingly seem to feel as if they need universities nearby. We've talked about this trend before, and Pfizer's current strategy makes it quite clear. Partnerships between industry and academia, of course, aren’t new. Yet Pfizer, Sanofi,... 75703@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-06-15T06:26:05-05:00 http://pipeline.corante.com/archives/2012/06/08/lessons_for_a_new_medicinal_chemist.php I gave my talk at the Drew University Medicinal Chemistry course, and it got me to thinking about when I was there (1990 or 1991), and my early days in medicinal chemistry in general. There are a lot of things... 75692@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-06-08T07:34:54-05:00 http://pipeline.corante.com/archives/2012/06/01/return_of_the_rhodanome.php I do hate to bring up rhodanines again, but I'm not the one who keeps making the things. This paper from ACS Medicinal Chemistry Letters turns out dozens of the things as potential inhibitors of the cellular protein dynamin, in... 75677@/home/corante/public_html/pipeline/ Drug Assays 2012-06-01T06:35:17-05:00 http://pipeline.corante.com/archives/2012/05/31/anonymous_grant_review_gets_a_try.php Anonymity is a topic that comes up whenever you talk about commenting on published scientific work. Some people are very uncomfortable with the idea of others being able to take potshots at them from behind convenient rocks, while others think... 75673@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-05-31T07:34:44-05:00 http://pipeline.corante.com/archives/2012/05/22/the_nihs_drug_repurposing_initiative_will_it_be_a_waste.php The NIH's attempt to repurpose shelved development compounds and other older drugs is underway: The National Institutes of Health (NIH) today announced a new plan for boosting drug development: It has reached a deal with three major pharmaceutical companies to... 75651@/home/corante/public_html/pipeline/ Academia (vs. Industry) 2012-05-22T11:12:46-05:00