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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

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« All Natural And Chemical Free | Main | Happy Fourth of July, 2014 »

July 3, 2014

An Early Day Off

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Posted by Derek

Since the Fourth of July looks to be a rainy washout around here, I'm taking a day off to get a head start on the holiday weekend here. So instead of advancing the cause of science in the lab today, I'm home with a big pork shoulder, which I rubbed down with salt and dry spices last night. It's now cooking over a low charcoal fire with plenty of green hickory wood (from a small shagbark hickory tree I spotted over in the forest near the back yard). That will cook the rest of the day, and be ready for dinner. Here's a prep for barbecued pork ribs from a couple of years ago.

Dessert will be the lime sorbet I mentioned here last year. If you're at all into lemon or lime as a flavor, give that one a try - it's easy, and the results from fresh lime juice are spectacular. Two large-scale, tested preparations, then, for today - I just have to keep an eye on things to make sure that everything is going according to plan.

Comments (12) + TrackBacks (0) | Category: Blog Housekeeping


1. Anonymous on July 3, 2014 10:40 AM writes...


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2. Crimso on July 3, 2014 10:42 AM writes...

You're being needlessly cruel to those of us who have to miss our normal celebrations. And that sorbet...

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3. Anonymous on July 3, 2014 12:21 PM writes...

I trust your lime sorbet will be chemical-free? ;)
Happy celebrations!

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4. Semichemist on July 3, 2014 1:17 PM writes...

#3 Unfortunately it looks like the recipe is loaded with sucrose, dihydrogen monoxide, citric acid, ascorbic acid, and other such chemicals. Hopefully next year Derek will switch to an organic alternative.

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5. Scripps on July 3, 2014 1:19 PM writes...

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6. Southern Transplant on July 3, 2014 1:51 PM writes...

As a fellow Southerner chemist in Boston, happy to report we are smoking a pork shoulder in the backyard too. Mesquite for us though.

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7. anon on July 3, 2014 5:30 PM writes...

This dude's got it easy man ! an experienced medicinal chemist knows how to slack off without making a big deal.

somehow we have succeeded in making therapies so expensive (poor cardiologists) that any idea can now be bottled and sold under "orphan drug" "breakthrough" and "fast track approval" paradigm. simple molecules can be sold for $ 84,000/- per regimen.

while I admire DL investing his time and effort in to blogging his peers are busy playing politics and honing the fine art of kissing the rear of anyone that can further their cause.

DL's blog used to be mostly gossip material, kinda' like the dark side stuff, however in 2014 there is a definite focus on scientific debate with the occasional "glaxo sex scandal" --- which is fine by me.

You have earned it DL. too bad for vertex, but i hope the blog topics earn him some credit on his 2014 review!

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8. Kimberly on July 4, 2014 2:22 AM writes...

Enjoy your dinner! I love the blog. Keep up the good work :)

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9. Anonymous on July 4, 2014 4:55 AM writes...

Nothin better than smoked pork

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10. jbosch on July 4, 2014 2:29 PM writes...

Hey Derek,
I can smell that pork - but why don't you open your front door ? I'm getting hungry now.

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11. Herveus on July 4, 2014 4:59 PM writes...

I made up the lime sorbet. ZOMG intense. That quart is going to last a long time. Thanks for the prompt.

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12. optmo on July 7, 2014 6:53 AM writes...

Happy time off. While you are away, I would like you to think about and get your feedback (and the followers) on this story. I personally think it is bad taste, not that Pfizer is above doing such things to gain the slightest edge but this one makes me nauseated.

Pfizer Receives Kosher Certification for Gaucher Disease Drug:

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