About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
Not Voodoo

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
A New Merck, Reviewed
Liberal Arts Chemistry
Electron Pusher
All Things Metathesis
C&E News Blogs
Chemiotics II
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
BBSRC/Douglas Kell
Realizations in Biostatistics
ChemSpider Blog
Organic Chem - Education & Industry
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
The Curious Wavefunction
Natural Product Man
Fragment Literature
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Eye on FDA
Chemical Forums
Symyx Blog
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa

Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
Gene Expression (I)
Gene Expression (II)
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
Cosmic Variance
Biology News Net

Medical Blogs
DB's Medical Rants
Science-Based Medicine
Respectful Insolence
Diabetes Mine

Economics and Business
Marginal Revolution
The Volokh Conspiracy
Knowledge Problem

Politics / Current Events
Virginia Postrel
Belmont Club
Mickey Kaus

Belles Lettres
Uncouth Reflections
Arts and Letters Daily
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Covalent Fragments | Main | No More Acid Stem Cells »

May 30, 2014

A New Med-Chem Reference

Email This Entry

Posted by Derek

Over the past few years, several readers here have recommended Silverman's medicinal chemistry book as an excellent introduction and reference. I wanted to mention that there's now a third edition: The Organic Chemistry of Drug Design and Drug Action, by Silverman and Holladay, which has just come out. Well worth a look for that part of the bookshelf.

Comments (11) + TrackBacks (0) | Category: Book Recommendations


1. Mansoon on May 30, 2014 12:27 PM writes...

I have had the privilege this past quarter of having professor Silverman as my Sophomore organic professor (its the honors section for chem majors) and I've been considering buying this textbook to peruse before taking med-chem with him next year. Now that there's a new edition out I'll have to get on that.

Permalink to Comment

2. CMCguy on May 30, 2014 1:21 PM writes...

I still have a 1st edition copy I purchased early in my career so guess just like having kids graduate from various levels of education the passing of time is some times marked by new editions of reference books on ones shelves.

Permalink to Comment

3. newnickname on May 30, 2014 2:15 PM writes...

I have Silverman 2nd Ed (2004) which is nice to have (for reasons I won't go into).

I've used the library copy of: Kerns and Di: "Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization" from 2008 which I think is also pretty good.

I guess it's a catch-up game: Will Kerns and Di come out with 2nd Ed soon? (Hmmm ... Kerns is retired and Di is re-located ... maybe updated with new co-authors?)

Permalink to Comment

4. Lyle Langley on May 30, 2014 3:19 PM writes...

@3, newnickname...

I would think there should be a 2nd edition of Kerns soon (I helped edit/comment on the new edition - and have the e-edition).

Permalink to Comment

5. Katey Birtcher on May 30, 2014 10:19 PM writes...

Happy to have worked on the new edition of Silverman's book, and happy to say there's a new edition of Kerns & Di coming as well. Much-anticipated revision for both!

Permalink to Comment

6. Anonymous BMS Researcher on May 31, 2014 9:54 AM writes...

@Lyle: I look forward to the new edition of Kerns and Di, the first edition was quite good.

Will the new edition remedy the omission of entries for "grease balls" and "brick dust" despite the common use of these phrases at Working Group Meetings :-)

Permalink to Comment

7. Anonymous BMS Researcher on May 31, 2014 10:00 AM writes...

Seriously, a major point correctly emphasized by Kerns and Di is that we must not lose site of other properties such as ADME and PK whilst chasing EC50 SAR. As they note, if we optimize purely for EC50 we risk getting stuck in a region of chemical space that binds the target site really really well but we cannot make a drug. We cannot always get around such issues with a pro-drug or some exotic formulation.

Permalink to Comment

8. Secondaire on June 1, 2014 1:09 PM writes...

@ #1 Mansoon

I have had the privilege of being a post-doc in Professor Silverman's group for the past eighteen months. Editing the index numbering in that book in time for the publisher's deadline was total murder, but a) it is a really terrific book, and b) Rick ordered lunch for the lot of us afterwards, so no harm, no foul. I hope you enjoy it and his med chem class, if you take it. Stop on up by Silverman Hall if you need help!

Permalink to Comment

9. annonie on June 2, 2014 8:16 AM writes...

#8: Only lunch....come now.

Permalink to Comment

10. Secondaire on June 2, 2014 2:01 PM writes...

#9: It was a really good lunch, though, believe me. :)

Permalink to Comment

11. Anonymous on June 3, 2014 12:52 PM writes...

@8 "Editing the index ...": If you had used TeX / LaTeX, indexing terms and their pagination would have been automated.

Yeah, I'm now forced to use POS Word like the rest of you. Dump Word! Use LaTeX! (Yes, it works quite well for chemistry papers, too.)

Permalink to Comment


Remember Me?


Email this entry to:

Your email address:

Message (optional):

The Last Post
The GSK Layoffs Continue, By Proxy
The Move is Nigh
Another Alzheimer's IPO
Cutbacks at C&E News
Sanofi Pays to Get Back Into Oncology
An Irresponsible Statement About Curing Cancer
Oliver Sacks on Turning Back to Chemistry