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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Where The Hot Drugs Come From: Somewhere Else | Main | Off To the Publishers »

April 1, 2014

Yeah, That Must Be It

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Posted by Derek

I'd sort of suspected this um, breakthrough, in catalysis that See Arr Oh is reporting. But how come more of my reactions don't work, eh? 'Cause there's been all kinds of crud in them, I feel pretty sure. Maybe the various crud subtypes (cruddotypes?) are canceling each other out. . .

Comments (21) + TrackBacks (0) | Category: Chemical News


COMMENTS

1. anonymous on April 1, 2014 6:42 AM writes...

Grins and giggles.

Permalink to Comment

2. anon on April 1, 2014 6:47 AM writes...

Hahnemann predicted all of this years ago: the key is ultra-low concentrations of catalyst...the glass gets imprinted and then catalyzes the reaction, unless you clean your glassware too well, or stir the reaction counter clockwise (clockwise in the southern hemisphere), which counteracts the effect.

Permalink to Comment

3. nona on April 1, 2014 7:39 AM writes...

I remember hearing about some early protein crystallisation attempts that failed to replicate at another laboratory due to the fact that the people there did not have beards. I wonder how that got written up...

Permalink to Comment

4. Curious Wavefunction on April 1, 2014 7:40 AM writes...

You need to have a new entry in the 'Lowe''s Laws of the Lab' category: "Lowe's 3rd Law: For every type of crud there's an equal and opposite crud".

Permalink to Comment

5. Anon on April 1, 2014 7:49 AM writes...

Given the state of much of the literature the claims seem valid

Permalink to Comment

6. oldnuke on April 1, 2014 8:52 AM writes...

@4 "Anti-crud"? gr

Permalink to Comment

7. jawn on April 1, 2014 8:59 AM writes...

You all do realize that this is April Fool's Day, don't you?

Permalink to Comment

8. nitrosonium on April 1, 2014 9:01 AM writes...

anyone know about the reproducibility of these things from lab to lab?

Permalink to Comment

9. See Arr Oh on April 1, 2014 9:12 AM writes...

@7 - Oh, was that TODAY? Wish I'd thought ahead...

Permalink to Comment

10. Pig Farmer on April 1, 2014 9:27 AM writes...

I blame those pesky Open Access Journals...

Permalink to Comment

11. henry's cat on April 1, 2014 10:06 AM writes...

@7 - You do understand irony don't you?

Permalink to Comment

12. ROGI on April 1, 2014 10:18 AM writes...

I remember in the early '80's a Sports Illustrated article on a guy call Mark Fydrich, an unknown rookie who could throw a 150 mph/270km fastball. The article went on for pages, until it dawned on one of the guys in the lab that it was an April Fool's joke. God, the Met sure (still)could use a southpaw like that!!

Permalink to Comment

13. Pig Farmer on April 1, 2014 10:22 AM writes...

@11. Henry's Catalyst. Irony, is that some fancy new kind of catalyst?

Permalink to Comment

14. Tim on April 1, 2014 10:29 AM writes...

We must characterize the crudome!

Permalink to Comment

15. Tim on April 1, 2014 10:29 AM writes...

We must characterize the crudome!

Permalink to Comment

16. Tim on April 1, 2014 10:30 AM writes...

A race to complete the crudome!

Permalink to Comment

17. MTK on April 1, 2014 11:01 AM writes...

@12,

Sidd Finch was the name of the player.

Permalink to Comment

18. Anonymous on April 1, 2014 11:07 AM writes...

@15:

Don't worry, we are trying!

dx.doi.org/10.1038/nmeth.2557

Permalink to Comment

19. Lyle Langley on April 1, 2014 11:48 AM writes...

@12, 17...
Yep, Sidd Finch. Mark "The Bird" Fydrych is/was a real pitcher for the Tigers ('76 ROY). Unfortunately he passed away several years ago. The Curious Case of Sidd Finch was written by George Plimpton and was one of the best April Fools jokes I can remember.

Permalink to Comment

20. anonymous on April 1, 2014 11:49 AM writes...

@13 It's a new element made by smashing iron and antimony together in a particle accelerator.

Permalink to Comment

21. Lyle Langley on April 1, 2014 11:50 AM writes...

@12, 17...
Yep, Sidd Finch. Mark "The Bird" Fydrych is/was a real pitcher for the Tigers ('76 ROY). Unfortunately he passed away several years ago. The Curious Case of Sidd Finch was written by George Plimpton and was one of the best April Fools jokes I can remember.

Permalink to Comment

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