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March 27, 2014
Another Target Validation Effort
Here's another target validation initiative, with GSK, the EMBL, and the Sanger Institute joining forces. It's the Centre for Therapeutic Target Validation (CCTV):
CTTV scientists will combine their expertise to explore and interpret large volumes of data from genomics, proteomics, chemistry and disease biology. The new approach will complement existing methods of target validation, including analysis of published research on known biological processes, preclinical animal modelling and studying disease epidemiology. . .
This new collaboration draws on the diverse, specialised skills from scientific institutes and the pharmaceutical industry. Scientists from the Wellcome Trust Sanger Institute will contribute their unique understanding of the role of genetics in health and disease and EMBL-EBI, a global leader in the analysis and dissemination of biological data, will provide bioinformatics-led insights on the data and use its capabilities to integrate huge streams of different varieties of experimental data. GSK will contribute expertise in disease biology, translational medicine and drug discovery.
That's about as much detail as one could expect for now. It's hard to tell what sorts of targets they'll be working on, and by "what sorts" I mean what disease areas, what stage of knowledge, what provenance, and everything else. But the press release goes on to say that the information gathered by this effort will be open to the rest of the scientific community, which I applaud, and that should give us a chance to look under the hood a bit.
It's hard for me to say anything bad about such an effort, other than wishing it done on a larger scale. I was about to say "other than wishing it ten times larger", but I think I'd rather have nine other independent efforts set up than making this one huge, for several reasons. Quis validet ipsos validares, if that's a Latin verb and I haven't mangled it: Who will validate the validators? There's enough trickiness and uncertainty in this stuff for plenty more people to join in.
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