About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

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« Big Drug Mergers: So They're OK, Right? | Main | For Immediate Rewording. Uh, Release. »

February 24, 2014

ACS Webinars on Drug Discovery

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Posted by Derek

I wanted to mention the ACS Webinar series on Drug Discovery, which will be going on every so often throughout the year. I'm going to be doing the introductory overview one, along with Rick Connell of Pfizer and Nick Meanwell of BMS, this Thursday, 2PM to 3PM EST. As you'll note from the schedule, there are plenty more of these coming up that go into more detail, so we're going to be setting the stage and taking questions from the audience.

Comments (10) + TrackBacks (0) | Category: Blog Housekeeping


1. SkepticMOA on February 24, 2014 1:37 PM writes...

Should we do a webinar on what happens after neuroscience drug discovery through Phase 3 really looks like?

1) Development of promising lead compound
2) Promising preclinical studies
3) Phase 1 studies, PK/PD, interaction
4) Phase 2a study with no efficacy endpoint
5) Discussions with the FDA, and FDA Division heads interject irrelevant and meaningless "suggestions" for demonstrating efficacy
5) Phase 2b "proof of concept" study, that in fact is barely positive
5.1) Senio executive leadership decided to move ehad because of good "portfolio management"
6) More discussion with the FDA, and almost unattainable, clinically meaningless inclusion/exclusion criteria are demanded. Additionally, rating instruments are selected that no one outside research is familiar with, nor demonstrate good inter-rater reliability amongst sites
7) Phase 3 program goes down in flames
7.1) If Eli Lilly, trumpet your "post-hoc" 34% reduction in cognitive decline, and move into a single phase 3 trial bigger than your original two phase 3 studies combined
8) Company "takes a charge" for R&D failure, all the while simply conducting trials in an area of high need enhances your "portfolio" and therefore stock value
9) Gracefully exit having made a 50% ROI
10) Rinse and repeat in another disease area

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3. lcollia on February 25, 2014 3:01 AM writes...

It seems very interesting, BUT what a shame that the webinars will happen at 2PM EST, i.e. at 8PM in Europe!!!

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4. Anonymous on February 25, 2014 4:15 AM writes...

@1: CNS = Crazy Noise-to-Signal

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5. interested on February 25, 2014 4:35 AM writes...

Do you have to watch these live?

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6. Chemjobber on February 25, 2014 9:20 AM writes...

No, traditionally ACS Webinars have been posted to YouTube about a week or two after they're recorded live. However, you may have to watch the ACS Webinars YouTube channel in order to catch the release.

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7. interested on February 25, 2014 12:36 PM writes...

Thanks. In the UK, that's too close to dinner time.

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8. Anonymous on February 26, 2014 4:01 AM writes...

Closer to tea time surely? ;)

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9. petros on February 26, 2014 8:11 AM writes...

re #8

UK terminology for meals (except breakfast) is a class/regional thing

midday = lunch (South/upper class) or dinner (North)
evening = dinner/supper and tea respectively

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10. Anonymous on February 27, 2014 2:59 PM writes...

Hi Derek,

Our med chem group was enjoying your discussion when we were disconnected following the poll. Any idea what happened? Looking forward to downloading the webinar recording and attending future sessions.

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