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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Biogen Idec Goes Open-Office | Main | Kurt Deshayes At The Challenges in Chemical Biology Conference »

July 25, 2013

DNA Can Be Messed With More Than You'd Think

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Posted by Derek

Ali Tavassoli has just given a very interesting talk at the Challenges in Chemical Biology conference on his SICLOPPS method for generating huge numbers of cyclic peptides to screen for inhibitors of protein-protein interactions. I'll do a post in detail on that soon; it's one of those topics I've been wanting to tackle. His lab is applying this to a wide range of PPI systems.

But he had a neat update on another topic, as well. His group has made triazole-linked DNA sequences, and investigated how they behave in bacteria. He now reports that these things are biocompatible in mammalian cells (MCF-7).

This opens up some very interesting artificial-gene ideas, and I look forward to seeing what people can make of it. The extent to which DNA can be modified by things like triazole linkages is remarkable (see here and here for other examples). What else is possible?

Comments (3) + TrackBacks (0) | Category: Chemical Biology


COMMENTS

1. Sili on July 25, 2013 10:03 AM writes...

But that's unpossible!

We all know that DNA is perfectly designed to be the best of all molecules in the best of all worlds!

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2. ESIMS on July 25, 2013 12:37 PM writes...

SICLOPPS is a neat way to do large scale generation of cyclic peptides. Way easier than messing with (aka evolution of) the PKS / NRPS systems. Of cause less versatile but way faster.

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3. JRL on July 25, 2013 10:25 PM writes...

I was at his talk. Interesting. Read his recent Jacs paper and it eems like a good approach. Would be interested in your take D.

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