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Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

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« The Price of Publishing | Main | Chemical Probes Versus Drugs »

March 29, 2013

Two New Books

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Posted by Derek

A colleague pointed out to me this week that there's a new edition of Copeland's Evaluation of Enzyme Inhibitors in Drug Discovery. I haven't seen this expanded and updated version, but the previous one was excellent. From the new preface:

. . .I have attempted to improve upon the first edition by substantially expanding most of the chapters with two overarching aims: to cover more completely the experimental aspects of the evaluation methods contained in each chapter and to enhance the clarity of the presentation, especially for the newcomer to applied enzymology. Toward these ends, a number of additional appendices have been added to the text, providing ready sources of useful information as they apply to quantitative biochemistry in drug discovery.

There are also two new chapters - one on residence time as a factor in enzyme inhibitor action, and another on the connections between in vitro enzymology and the factors in vivo that have to be considered for drug candidate selection. I have no problem recommending this one just on this basis.

And on a different (but still very useful) level, Erland Stevens of Davidson College has sent along a new textbook on medicinal chemistry that he's written for the advanced undergraduate/grad student market. I've looked it over, and it's a fine intro to the field, covering an impressively wide range of topics. All the classic stuff is there, but you'll also find references up to at least 2010, including things like George Whitesides' paper on linkers in fragment-based drug design, the structure of the P2X4 ion channel, and screening of crystallization conditions for API synthesis. If I were teaching a survey course on medicinal chemistry, I would be glad to use this as a text.

Comments (2) + TrackBacks (0) | Category: Book Recommendations


1. Curious Wavefunction on March 29, 2013 1:37 PM writes...

Both of these look worthwhile. There's also a new edition of Patrick's excellent "Introduction to Medicinal Chemistry" that came out this month.

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2. Dan on April 4, 2013 5:18 AM writes...

Phil Baran has an interactive "textbook" out for iPad - check the Baran Group blog for more details. Just seen it and thought it might be of interest to other readers here.

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