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March 13, 2013
Who to Manufacture an API?
Here's a very practical question indeed, sent in by a reader:
After a few weeks of trying to run down a possible API manufacturer for our molecule, I am stuck. We have a straightforward proven synthesis of a 300 weight lipid and need only 10 kg for our trials. Any readers have suggestions? Alternately, we will do it ourselves and find someone to help us with the documentation. Suggestions that way, too?
That's worth asking: who's your go-to for things like this, a reliable contract supplier for high-quality material with all the documentation? I'll say up front that I don't know who's been contacted already, or why the search has been as difficult as it has, but I'll see if I can get more details. Suggestions welcome in the comments. . .
Update: this post has generated a lot of very sound advice. Anyone who's approaching this stage for the first time (as my correspondent clearly is) is looking at a significant expenditure for something that could make or break a small research effort. I'm putting this note up for people who find this post in future searches - read the comments; you'll be glad you did.
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