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January 7, 2013
A couple of years ago, I referred to a journal article summarizing many recent examples of bioisosteres in medicinal chemistry. I've been meaning to mention a book that came out late last year, Bioisosteres in Medicinal Chemistry. It looks to be a compendium of all the latest information on functional group substitutions and their effects on solubility, pharmacokinetics, metabolism and the like. Worth a look if this is one of your interests - you can look over the table of contents at that Amazon link.
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