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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

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In the Pipeline

« There Will Be No More Woodwards | Main | Texas And Its Cancer Funding »

October 15, 2012

A New Diels-Alder

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Posted by Derek

There may be no more R. B. Woodwards, but never let it be said that there's nothing more to be found in organic synthesis. Until we can make natural products the way that they're made in nature, at room temperature, atom by atom, our skills don't stand comparison with what we know is possible. But that's not going to be the work of a single genius, for sure, although applications are always being accepted.

New reactions, though, are always out there. Here's an example of one, in a field (the Diels-Alder reaction) that you'd think would have been pretty well worked over. This will win no Nobels, and only synthetic organic chemists will pay attention. But I'm always glad to see discoveries like this, and to know that they're still out there.

Comments (6) + TrackBacks (0) | Category: Chemical News


1. Anonymous on October 15, 2012 11:23 AM writes...

Prof. Hoye was trained by RBW.

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2. BeenThereDoneThat on October 15, 2012 5:40 PM writes...

Tom Hoye was the best consultant (by far) we had when I was in Pharma. Hats off to you, Tom.

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3. Norrish type II on October 16, 2012 6:29 AM writes...

Have you seen the substrates, come on, give me a break. This reaction is almost useless and doesn't solve any particular problem. Just like the Norrish type II !

@ 2, give me a break also, or at least remove your "by far"

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4. Anonymous on October 16, 2012 9:47 AM writes...

@ 3: I love posts like this. So the substrates need to be drugs??? They didn't have to add anything to reaction mixture and it works!

Also how else do you make a per substituted benzene???

Gotta say Norrish, you are sounding like a jealous grad student.

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5. Anonymous on October 16, 2012 11:05 AM writes...

No!!! My name (use to be) Peter Wagner, now of the Pearly Gates, formerly of Michigan State University. I spent my entire carrier bouncing electrons by light (vs darkness, heh, heh, heh..) from my former ground state to the n Pi Star level). If you look up into the clear night sky, you will be amazed at what these things can do.
You may reach me at any time in the evening calling Our Father...)

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6. Anonymous on October 20, 2012 9:43 PM writes...

Not much new

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