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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« EMBL Chemical Biology: Polypharmacology | Main | Elan's Discovery Efforts - What's Going On? »

September 28, 2012

EMBL Chemical Biology: The ChEMBL Database

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Posted by Derek

John Overington from the EMBL is talking about the ChEMBL database, which is an impressive collection. One thing that I appreciate is that he's being upfront about the error rates in the data. He takes the reports of trouble seriously, but feels (overall) that considering the amount of data they have, and the amount of annotation associated with it, that they've done well.

There are an awful lot of ways that you can work the numbers from their web site, which is both good and bad. If you know what you're doing, you can get some very interesting and potentially useful results, but if you don't, you can mislead yourself more quickly and thoroughly than you ever could by hand. That's common to all powerful tools, naturally.

My talk is right after the next speaker, so I won't be posting for a bit. And no, I will not be writing a critique of my own talk while I'm giving it; that would be a Blog Singularity of some sort.

Comments (5) + TrackBacks (0) | Category: Chemical Biology


COMMENTS

1. UKPI on September 28, 2012 7:24 AM writes...

He also mentioned that, on average, pharma currently synthesises 250,000 compounds per approved drug...how much would that cost?

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2. UKPI on September 28, 2012 7:25 AM writes...

He also mentioned that, on average, pharma currently synthesises 250,000 compounds per approved drug...how much would that cost?

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3. Petros on September 28, 2012 8:01 AM writes...

Given the cost of developing a new drug to market is only $43 million, the cost of synthesising 250,000 cpds is probably only a few thousand dollars (In Lightomics that is)!

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4. UKPI on September 28, 2012 8:29 AM writes...

No problem though...soon we will have several thousands of triazine-based drugs...

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5. UKPI on September 28, 2012 8:30 AM writes...

No problem though...soon we will have several thousands of triazine-based drugs...

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