Corante

About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Emolecules
ChemSpider
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
PubChem
Not Voodoo
DailyMed
Druglib
Clinicaltrials.gov

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
Kilomentor
A New Merck, Reviewed
Liberal Arts Chemistry
Electron Pusher
All Things Metathesis
C&E News Blogs
Chemiotics II
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
BBSRC/Douglas Kell
ChemBark
Realizations in Biostatistics
Chemjobber
Pharmalot
ChemSpider Blog
Pharmagossip
Med-Chemist
Organic Chem - Education & Industry
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
SimBioSys
The Curious Wavefunction
Natural Product Man
Fragment Literature
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Business|Bytes|Genes|Molecules
Eye on FDA
Chemical Forums
Depth-First
Symyx Blog
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa


Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
FuturePundit
Aetiology
Gene Expression (I)
Gene Expression (II)
Sciencebase
Pharyngula
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
Cosmic Variance
Biology News Net


Medical Blogs
DB's Medical Rants
Science-Based Medicine
GruntDoc
Respectful Insolence
Diabetes Mine


Economics and Business
Marginal Revolution
The Volokh Conspiracy
Knowledge Problem


Politics / Current Events
Virginia Postrel
Instapundit
Belmont Club
Mickey Kaus


Belles Lettres
Uncouth Reflections
Arts and Letters Daily
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« EMBL Chemical Biology: Natural Product Leads | Main | EMBL Chemical Biology: Covalent Probes »

September 26, 2012

EMBL Chemical Biology: Weird Aggregating Compounds

Email This Entry

Posted by Derek

Now I'm listening to Jim Wells (UCSF) talk about (among other things) this work, where they found a compound aggregating and causing activity in their assays. But this one wasn't doing the standard globular gunk that the usual aggregation gives you. Instead, the compound formed nanofibrils - microns long. And the enzyme that the compound showed activity against turns out to bind to the surface of the fribrils. Wells likens the effect to the way that Brussel sprouts grow, and his electron micrograph does indeed look pretty close. The question is, does this mimic something that happens "in real life", or is it a complete artifact? There's a paper in press in JBC going into some of the details. Just goes to show you that compounds are capable of doing things that you'd never have been able to guess.

Comments (6) + TrackBacks (0) | Category: Chemical Biology


COMMENTS

1. lynn on September 26, 2012 5:11 PM writes...

If not ontogeny recapitulates phylogeny, then chemistry recapitulates Brussels sprouts. I'm liking your ongoing meeting abstracts, Derek.

Permalink to Comment

2. Fries With That? on September 26, 2012 8:09 PM writes...

Complete artifact. Lipstick on a pig.

Permalink to Comment

3. Inefficient Reaction on September 27, 2012 9:23 AM writes...

Jim Wells removes those tags on mattresses!

Permalink to Comment

4. Anonymous on September 27, 2012 9:51 AM writes...

It is disturbing that Wells published a science paper to claim a hit molecule that works as a monomeric ligand, then published another one in JACS to retract the claim in the Science paper. HTS fooled many people. I am not sure Wells's result is reproducible.

Permalink to Comment

5. UmemployedMedChemist on September 27, 2012 12:29 PM writes...

The association of the enzymes on nanofibrils brings up all sorts of potential applications for protein drug delivery. Factor VIII or ADA comes quickly to mind. It could be a replacement for PEGylated protein delivery.

I'm sure Dr. Wells has had the incredible smart foresight to consider such obvious applications.

Permalink to Comment

6. Anonymous on September 27, 2012 10:37 PM writes...

UnemployedMedChemist:
Considering that Wells own data showed these so-called NanoFibrils kill every cell they are sprinkled on, probably not such a great idea for protein delivery. A company called Calithera was founded on the Science paper results, strangely, Wells and Calithera do not seem to be associated with each other anymore.

Permalink to Comment

POST A COMMENT




Remember Me?



EMAIL THIS ENTRY TO A FRIEND

Email this entry to:

Your email address:

Message (optional):




RELATED ENTRIES
A Last Summer Day Off
The Early FDA
Drug Repurposing
The Smallest Drugs
Life Is Too Short For Some Journal Feeds
A New Look at Phenotypic Screening
Small Molecules - Really, Really Small
InterMune Bought