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September 26, 2012
EMBL Chemical BIology: Natural Product Multiheterocycles
Chris Walsh of Harvard is talking about the trithiazolylpeptide antibiotics and related compounds. If you thought that only we synthetic organic chemists were crazy enough to link three more heterocycles onto a central pyridine, leading to compounds which "have the solubility of sand" (a direct quote from Walsh), then think again. And they weren't even made by palladium-catalyzed couplings! Since we were talking about macrocycles here the other day, it's worth noting that these are also 29-membered rings and the like.
Here's one of them for you, if you haven't seen these beasts before. Who's synthesized it? Funny you should ask. . .
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