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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« EMBL Chemical Biology: Covalent Probes | Main | EMBL Chemical Biology: Labeling Proteins »

September 26, 2012

EMBL Chemical BIology: Natural Product Multiheterocycles

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Posted by Derek

Chris Walsh of Harvard is talking about the trithiazolylpeptide antibiotics and related compounds. If you thought that only we synthetic organic chemists were crazy enough to link three more heterocycles onto a central pyridine, leading to compounds which "have the solubility of sand" (a direct quote from Walsh), then think again. And they weren't even made by palladium-catalyzed couplings! Since we were talking about macrocycles here the other day, it's worth noting that these are also 29-membered rings and the like.

Here's one of them for you, if you haven't seen these beasts before. Who's synthesized it? Funny you should ask. . .

Comments (2) + TrackBacks (0) | Category: Chemical Biology


COMMENTS

1. anonymous on September 26, 2012 7:26 PM writes...

Hey Derek: I guessed correctly!!!! What do I win?

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2. SteveM on September 26, 2012 7:55 PM writes...

Hmm... Long ago and far away, (well not that far - Philadelphia), I attended a talk K.C. gave when he was at Penn and I was an undergrad at Drexel.

K.C. exuded a certain flamboyant arrogance then. I eventually got out of Chemistry. Has he changed much?

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