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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Those Drag-Over-the-Coals Interviews | Main | EMBL Chemical Biology: Weird Aggregating Compounds »

September 26, 2012

EMBL Chemical Biology: Natural Product Leads

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Posted by Derek

I'm listening to Paul Hergenrother (of Illinois) talk about using natural products as starting materials for compound screening libraries. It's a good idea - he takes readily available complex structures and does a range of organic chemistry on each of them, to make non-natural structures that have the complexity and functionality of natural products. I note that he's taken adrenosterone and made azasteroid derivatives (among many others), very similar to what I talked about here. He's also used quinine, gibbererlic acid, and others.

He's taken the collection thus produced and run them through phenotypic cell screens, with what look like interesting preliminary results. The idea is to look for unusual phenotypes and work backwards to new targets from them, so having a pile of unusual compounds is probably a good starting point. Of course, I have a weakness for phenotypic screens in general, and I suspect I'm going to be hearing a lot about them here over the next few days.

Comments (2) + TrackBacks (0) | Category: Chemical Biology


COMMENTS

1. imatter on September 26, 2012 11:01 AM writes...

I wonder if some are Zn chelators.

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2. Anonymous on September 26, 2012 11:32 AM writes...


Don't be afraid to be a bit skeptical about those 'interesting preliminary results' - see http://tinyurl.com/3n8pd8 and http://tinyurl.com/8uzhfcy

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