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About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

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January 11, 2012

Ten Years of Science Blogging. Already?

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Posted by Derek

Today marks my ten-year blogging anniversary. That doesn't seem possible, but there it is: ten years since I sat down and chose a Blogger template and starting typing away into the void. So what have I learned in all that time (and after all that blather?)

Where It Fits and How It's Done
I may well have been the first science blogger, because it didn't take me long to start talking about drug discovery, as opposed to current events and the like. (Even in 2002, I thought that blogging the news was an overcrowded field, and little did I know how much more crowded it would become). But blogging drug discovery still isn't a very crowded field at all, for various reasons. One of those surely is that most of it is done in an industrial setting, and very few people have felt comfortable blogging from inside a drug company.

The fact that I do so might be due to circumstances that are hard to repeat. It helped that I started out before most people had any idea of what a blog was, and it probably helped that my company's highest management levels at the time were on another continent and spoke another language. And naturally, it's also helped that I've carefully avoided ever being seen as a spokesperson for any company I've worked for. (Or a source of inside information, God forbid). But there are so many topics to write about that this has never been a real problem. When I started, I wondered if I'd be able to keep things up, but there's hardly a day when I don't find something to write about. The material just keeps coming, and I'm glad of it.

That's because I actually enjoy doing this - I don't suppose I could have lasted this long if I didn't! I compose quickly, and type quickly, which helps keep blogging from becoming a chore. As for what to write about, keeping up with the literature and the industry is something that I would have been doing already, and it really doesn't add much time to sit down and write up something about what I've been reading and thinking. (It helps, in fact, to clarify my thoughts - I'm sure that I retain a lot more information for having blogged about it).

Who Reads It, Anyway?
As it happens, a lot of people really do seem to be interested in this stuff. That was my hope - one reason for blogging was that every time I talked to people outside science about what I did for a living, they seemed to think (1) that it was a really neat job, and (2) that they'd never heard of it being a job at all. No one really seemed to know where drugs came from, and despite my efforts (!), most people still don't.

I get letters all the time, though, from non-scientists who read the site, and they make me very happy. Not everything here is accessible or interesting to non-scientists, but I try to make sure that enough of it is to keep people hanging around. And then there are the scientist readers themselves, who make of the bulk of the audience around here. To them I owe a rare distinction: one of the highest signal-to-noise ratios in in the entire world of blog comments. That's really the case - other bloggers have asked me many times what I do to keep things from devolving, and I tell them that it isn't me, it's the people who come here. It's not like every comment thread is a river of gold, but there's a lot more gold there than you'd expect from general run of the blog world.

Readership has increased steadily over the years. Here's the chart, minus the first couple of years, which tail off just the way you'd think, and minus a few months back in 2006, around the time the Wonder Drug Factory was running into trouble and I forgot to save the stats.
blog%20traffic%20chart.png
Basically, every time I think that the numbers have plateaued, they haven't. Most recently, mid-2010 to mid-2011 had pretty much the same readership levels, but lately things seem to be rising yet again. (And note that my stats don't pick up people who see the blog on RSS feeds, which I think has been an increasing percentage over the years). Far more people are willing to read about chemistry and drug discovery than I ever imagined.

Day-to-day, posts about misery (huge layoffs and the like) get a lot of traffic, which says something about human nature that close observers will have already noted. But a steady diet of misery lacks a number of essential nutrients. The "Things I Won't Work With" posts get the largest non-scientific readership, which is why I'm whacking them into book shape (to appear first on the Kindle, etc.) And posts about patents and IP issues almost always drive a small but noticeable number of people away - if I did a solid week or two of those, who knows if the site would ever recover.

Overall, though, the site has had what I think is a fairly consistent tone over its whole history. That may be because I have a fairly consistent tone myself. A few years ago, I was unnerved when I started looking over some of my older posts and thought that they were clearly better than anything I was turning out at the time. But that seems to be a general psychological effect - older posts always, eventually, look more polished to me because I still have the fresh experience of tumbling the new ones out onto the page. The old ones felt the same way at the time, though. Hindsight polishes them up.

What's Changed
The drug industry is a very different place than it was when I started blogging. Basically, every time I've thought that the worst had passed, it hadn't. I hate to be that negative-sounding, but it's hard to deny that the last ten years - especially the last six or seven of them - have been some of the roughest water that drug R&D has ever experienced. I never thought that I'd have to work at keeping the site from becoming the Blog of Constant Pharma Layoffs, but I've had to.

But that said, the way the industry works hasn't really changed over that time, not in any fundamental ways. (Those two trends may not be unrelated). We have some techniques now that weren't used much back then, but the broad strokes of the business are identical: find some hits, most likely through screening. Develop them into leads, and turn the med-chem people loose on them to do SAR. Fix the potency, fix the selectivity, fix the PK, and then put them into tox and cross your fingers. Send the winning compound to the clinic, put it into Phase I and cross your fingers, this time on both hands. Send it to Phase II, crossing all your fingers, your toes, and your lower intestines. And send it to Phase III, crossing all those body parts while sacrificing a two-headed goat and barbecuing it over bales of money. You know, the usual grind.

The scientific literature has changed, though - and in almost every way, it's become more like blogging and less like it used to be. Print journals have looked archaic for some time, and will likely continue their vanishing act. I haven't seen a hard copy of any of the journals I read in. . .months? Years? Articles get published online, discussed online (shared, boosted, or picked apart), and their authors, their publishers, and their readers are paying attention to things like traffic stats, comments, and links. That'll continue, too, and I think that science will be better off for it.

What's Coming
For the industry? I have no idea. Well, that's not completely true. I have several ideas, but they can't all be right at the same time. For this blog? That's easier - I have every intention of keeping it going, because I still enjoy it. And it's opened up a lot of opportunities that I never would have had otherwise. I had no idea what was going to happen when I started it, although it's safe to say that I wasn't exactly planning on it becoming one of the key turning points of my life. But that's what happened. Here's to more of it!

Comments (95) + TrackBacks (0) | Category: Blog Housekeeping


COMMENTS

1. Myma on January 11, 2012 9:04 AM writes...

and the y-axis units are ... ?

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2. AJ on January 11, 2012 9:14 AM writes...

#1: Unique readers I'd say.

Congrats Derek, it's always a pleasure to keep up with your blog. Many well wishes, and I eagerly await the book!

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3. Chemjobber on January 11, 2012 9:14 AM writes...

Pageviews, probably.

Congrats, Derek, on ten great years, from someone who was so pleased to google "organic chemistry blog" and find you!

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4. luysii on January 11, 2012 9:17 AM writes...

Always interesting, always well written. You deserve all your success. Looking forward to another 10 for you.

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5. Nathan T on January 11, 2012 9:20 AM writes...

Thanks Derek for 10 years of great posts! Congratulations.
I picked up your blog while working as a med chemist at a biotech back late 2002 or early 2003. I've followed it ever since. You've been a great source for encouragement, insight, gossip, and shared heartache. I've been through 2 major career moves since that time, and your blog has sometimes been a source of consistency during all the turmoil. You’ve been a steady reminder that pharmaceutical science really is fun and beneficial - even while company politics, layoffs, and the economy all wreak havoc on us all.
For many years now my typical routine is to catch up on email, do a bit of lab work, and then relax with a cup of coffee while reading your latest post. Here’s to many more years of sharing my morning coffee with you! All the best.

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6. See Arr Oh on January 11, 2012 9:28 AM writes...

Congrats, Derek! Been hanging around the blog since grad school, so it's been a unique pleasure to watch you emerge as a science writing champion while the industry slid downhill.

Thanks for your clear voice, direction, and vision for the field. It's fair to say that I wouldn't be blogging about drug discovery without you to start me up.

Thanks, and good luck!

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7. Anonymous on January 11, 2012 9:33 AM writes...

Keep'em coming!!!

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8. johnnyboy on January 11, 2012 9:33 AM writes...

Amazing work, Derek. Congratulations !

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9. Gary on January 11, 2012 9:48 AM writes...

Happy Anniversary! I really enjoy your blog--I drop in on others from time-to-time, but this is the only blog I find interesting enough to read on a daily basis. Great job!

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10. Peter Scott on January 11, 2012 9:48 AM writes...

I don't read many blogs, but always this one. Also the Chem World articles are much appreciated. Here's to you...

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11. Eve on January 11, 2012 9:54 AM writes...

Congratulations on 10 years.

I came for Things I Won't Work With (and How Not To Do It) and stayed for everything else. I'm not a scientist or involved in the pharma industry, but I find your insights very interesting.

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12. Anonymous on January 11, 2012 9:54 AM writes...

Happy Anniversary Derek! Here to several more decades of informing us, making us think, and sometimes making us mad. Keep up the good work.

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13. Curious Wavefunction on January 11, 2012 9:59 AM writes...

Congrats, it's been a terrific record! Here's to (at least) ten more.

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14. lynn on January 11, 2012 10:02 AM writes...

Congratulations and Happy Anniversary, Derek. I always read this blog - and miss it on the weekend. It's nice to have a place where the reality of drug discovery and Pharma is discussed from the POV of the scientist. So, thanks to your posts - and to the great discussions.

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15. processchemist on January 11, 2012 10:11 AM writes...

Congratulations, Derek, I think we all hope in ten more years of this blog.

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16. patentgeek on January 11, 2012 10:34 AM writes...

Congrats also, Derek, and a big "Thank you" for the considerable thought and effort you've put into making this place a community, not just a blog. Along with all the great pharma/chem content, your garnishes of shared recipes, SF fannishness, wry humor, etc. really make this a home for some of us. (Your French onion soup recipe from a couple of years ago is still the best I've found.) May your blogging continue to be auspicious for you!

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17. Hap on January 11, 2012 10:36 AM writes...

Thank you, Dr. Lowe, for writing this blog. It has been really useful.

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18. MeanRegression on January 11, 2012 10:38 AM writes...

@ 1,2,3: It's layoffs, sillies!

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19. J Cerro on January 11, 2012 10:42 AM writes...

Congrats, Derek!

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20. processchemist on January 11, 2012 10:46 AM writes...

Congratulations, Derek, I think we all hope in ten more years of this blog.

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21. Nick K on January 11, 2012 10:51 AM writes...

Great blog, Derek. Here's to the next decade!

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22. 3TC on January 11, 2012 10:59 AM writes...

Great stuff generally with an enviable array of regular commentators who add useful content and humor. It should be a must-read for all of senior pharma though many of them would not be best pleased with coverage of their companies.

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23. anon the II on January 11, 2012 11:25 AM writes...

Congratulations on ten years! I've been a reader since close to the beginning and I've enjoyed it immensely. Here's to many more.

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24. pete on January 11, 2012 11:29 AM writes...

My hat's off to you, Derek, in managing to maintain over the course of a decade of daily writing: i) an even-handed tone, ii) thoughtful choice and commentary on a wide range of topics, iii) clear statement and support for your opinions, and iv) ability to attract and bring along a growing audience of diverse, high-quality contributors (pat-on-the-back all 'round, here).

IMHO, that's quite an impressive feat -- Bravo!

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25. Don Keefhardt on January 11, 2012 11:30 AM writes...

Love the "Things I Won't Work With" series !

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26. Cellbio on January 11, 2012 11:32 AM writes...

Great stuff! In the Pipeline is the first bookmark on my bar and I enjoy the morning read with my first cup of coffee everyday. It has become my version of a local paper, and in that sense, a real community for me, thanks.

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27. CMCguy on January 11, 2012 11:36 AM writes...

Congrats Derek as seems always mentally stimulating and fresh even when covering repeated topics. Certainly the wit of yourself and many commentators often generate chuckles during the day. You did not mention your occasional Recipes which I feel expresses a relevant connection of Chemistry in action for the general public.

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28. cicely on January 11, 2012 11:37 AM writes...

Happy Blogiversary!

I think I found this blog through someone's link to one of your "Things I Won't Work With" posts (which made me aspirate my Diet Coke, thank you so very much!), but found the 'other stuff' unexpectedly interesting, too. I'd never given the World of Drug Research much thought, but am finding it, from the outside at least, easily more interesting than, say, The Snookie Show, or much of the other mainstream 'entertainment' on offer.

In conclusion---thank you, and please keep doing just what you're doing.

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29. Jay Manifold on January 11, 2012 11:53 AM writes...

I can neither add anything substantive to the above sentiments nor successfully resist the temptation to comment anyway. Derek, the world is a better place because of what you have done. Keep it up!

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30. Anonymous on January 11, 2012 12:26 PM writes...

Congrats on 10yrs Derek. I remember that cold morning in Jan. 2002 when you passed by my office in B22 at our former employer, and mentioned your blog and hoping to get some readership. Look what it has become ! Keep up the good work.

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31. Glenn Friedman on January 11, 2012 12:26 PM writes...

Derek, Happy Anniversary and congrats on 10 yrs of blogging. I've been a reader for about 8 yrs and always look forward to your objective insights on the Pharma industry. It will be interesting to see what the next 10 yrs bring.

Glenn

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32. ajay malik on January 11, 2012 12:30 PM writes...

Hi Derek, congratulations on the 10th anniversary of this blog. I think what's coming is the integration of FDA and other governmental organizations into the social media and blogging world. With major journals setting up blogs and reader comment sections on the web, the next on the list are the likes of FDA--people trust (and need) authentic sources of information besides professional forums like yours!

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33. pete on January 11, 2012 12:34 PM writes...

Now that I think of it, we ought to have a virtual beer party to celebrate. I'll bring the onion dip...you know, that concoction of onion soup mix substance + brand-X sour cream substance. It doesn't taste half-bad in cyberspace.

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34. daen on January 11, 2012 12:58 PM writes...

I'll echo the sentiments of the commenters above me: happy 10th blogaversary!

Over that decade, what do you think would be the industry's most surprising development to your younger self?

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35. marklar on January 11, 2012 1:07 PM writes...

I've been reading your blog for ~9 years now and I'm always impressed by the quality/content of your writing. It's nice to have a Med Chemist on the 'inside' voicing the concerns/issues that so many other scientists have in the industry but are unwilling to express.
Keep up the great work Derek!

Laid off Chemist

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36. Drug Developer on January 11, 2012 1:09 PM writes...

Ditto, ditto, ditto. Congratulations, and here's to (at least) 10 more!

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37. Bernard Munos on January 11, 2012 1:10 PM writes...

Daily food for thought. I could not imagine life without it. Thanks!

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38. Clinicalpharmacogist on January 11, 2012 1:34 PM writes...

Derek, your blog is required reading and I never miss it. Thank you for a thought provoking 10 years.

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39. JasonP on January 11, 2012 1:38 PM writes...

Ya, Derek, long-winded blog entries about your blog are...lame.

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40. Curt F. on January 11, 2012 1:39 PM writes...

I was late to the party, reading the blog since 2008. I've really enjoyed every post since then, and many (but not all!) of the comments made too.

Congratulations on 10 years. It really is remarkable, and you should be proud of the achievement.

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41. Thomas McEntee on January 11, 2012 2:02 PM writes...

Congratulations and thanks!

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42. Anonymous on January 11, 2012 2:50 PM writes...

Derek: Congratulations on a job well done! But, what happened between 6-August and 7-Jan?

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43. usedtobeatIRBM on January 11, 2012 3:16 PM writes...

Congratulations, and many thanks Derek. I have read it every day for 7 or 8 years, and consistently enjoy it. (Almost) always well balanced and always intelligent and well written.

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44. coprolite on January 11, 2012 3:38 PM writes...

Happy anniversary! I can't read a lot of the words, but sometimes there are pictures, and I can't read those either.

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45. The Blue Maharajah on January 11, 2012 3:40 PM writes...

Your blog has created a community of Medicinal Chemists, just when we needed one most.

Thank you.

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46. Katherine on January 11, 2012 4:09 PM writes...

I took Chem 111 at my local community college in 2005 just because Derek makes it sound so interesting. Had fun, too. :)

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47. Joe Loughry on January 11, 2012 4:24 PM writes...

Reading your blog kept me sane in grad school.

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48. Biased Agonist on January 11, 2012 4:42 PM writes...

10 more years, 10 more years!
The amazingly wide variety of topics!
The personal, insider's perspective! Incisive, yet fun to read!
The high level discussions in the comments section!
Been a daily reader for the past 6 years. I'm hooked.
Thank you Derek.
Keep up the chemistry posts, the IP posts, and those about clinical trials, careers in science, business issues, quackery, recipes of chocolate pecan pie and all !

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49. Bruce Hamilton on January 11, 2012 4:53 PM writes...

Derek,

Thanks for all the posts - a huge effort that's highly appreciated. Thanks also to almost all of the people who comment, they add lustre to the gem.

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50. Pete on January 11, 2012 5:25 PM writes...

Congrajulations on the 10 year anniversary. The very first thing after checking e-mails in the morning to read. Been doing that for about 8 yrs.

Thank you

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51. Josh on January 11, 2012 5:37 PM writes...

Derek-
It is no accident that have pulled this off. Excellent writing + Sense of Humor + Amazing breadth of knowledge + Major smarts.
There is no one who compares.
Keep it up.

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52. TX Raven on January 11, 2012 5:45 PM writes...

Nice job, Derek.

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53. Happy on January 11, 2012 6:04 PM writes...

Congratulations, and Happy Blog Day!

Thank you for sharing your perspective on the industry... it helps the young 'uns like us... :)

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54. Gaythia on January 11, 2012 6:27 PM writes...

Congratulations! This blog is a real contribution to those of us who care about chemistry and the chemistry profession.

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55. milkshake on January 11, 2012 7:36 PM writes...

After a long and hopeless job hunt, I got my current employment through a plug from Derek - a job that I am enjoying a great deal. Also, In the Pipeline is also responsible for directing lots of traffic into Org Prep Daily. So yes, you are a gentleman and a scholar.

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56. Anonymous BMS Researcher on January 11, 2012 8:14 PM writes...

I agree with others: congrats to Derek on 10 years of great blogging, and kudos to the community of commentators here. Y'all really are a great bunch.

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57. Carmen on January 11, 2012 9:01 PM writes...

Congrats, Derek. I've always admired your ability to write about drug discovery in an engaging way. And like milkshake, I'm grateful for the link love/exposure you gave the blog I wrote in grad school, when I was trying to break in to science writing. Here's to many more years!

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58. Susurrus on January 11, 2012 9:18 PM writes...

10 years! Where have you been, man?
http://m.youtube.com/index?desktop_uri=%2F&gl=US#/watch?v=-pupHeSHOEE

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59. Jason on January 11, 2012 9:25 PM writes...

Non-scientist here. (Still an undergrad.)

I came for "Things I Won't Work With" and "How Not to Do It", but I've found a lot of your posts entertaining over the years.

You're one of the main reasons I decided to go into the chemical field.

Keep inspiring others to join in the misery.

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60. MoMo on January 11, 2012 9:30 PM writes...

Congratulations Derek! You and this blog and its cultural influence will be studied someday in some class somewhere, and I hope it is soon!

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61. MoMo on January 11, 2012 9:37 PM writes...

#1 Myrna,

The Y axis? This is number of chemists out of work since this blog started.

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62. Susurrus on January 11, 2012 9:46 PM writes...

Sorry. The hyperlink in my last post should have been: http://www.youtube.com/watch?v=-pupHeSHOEE

Damn mobile devices!

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63. MJ on January 11, 2012 10:27 PM writes...

Congratulations on the 10 year milestone! I've been reading for many years, and look forward to more great years!

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64. Anonymous on January 11, 2012 11:07 PM writes...

Yours is the best science blog on the net.

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65. Anonymous on January 11, 2012 11:12 PM writes...

Congrats! The absolutely best blog on the planet, bar none!

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66. Mutant Dragon on January 11, 2012 11:13 PM writes...

Congrats! I love your blog -- it's become a morning ritual for me, in fact. Keep it up!

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67. srp on January 11, 2012 11:17 PM writes...

I haven't been as good about checking in lately, but I'm happy to say that you've informed and amused me and become a trusted source of information on pharma and medchem issues. Best of luck with the next ten years.

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68. hn on January 12, 2012 1:24 AM writes...

Thanks for your dedication, Derek. I love this blog. It's the only blog, science or otherwise, that I read regularly. I regularly recommend this blog to students and postdocs to get a peep into the life of industry scientists.

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69. HTS_Guy on January 12, 2012 1:26 AM writes...

Congradulations! Keep up the good work.

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70. shaji varghese on January 12, 2012 4:04 AM writes...

Congratulations Derek!

Thanks for all the posts.

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71. Morten G on January 12, 2012 5:23 AM writes...

10 years? God - at least I've only been reading it for half of that time. Nice work!

I think one of the reasons your comments are (usually) worthwhile is that you update your posts based on comments and base new posts on comments.

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72. KissTheChemist on January 12, 2012 7:39 AM writes...

One big reason I have for reading this excellent blog is it's humanity. Particularly when bringing news of lay-offs, take-overs and the like.

One of my other favorite things is SNAKE OIL posts. Charlatan-bashing is goooood!! (Remember the wine molecule guy??)

So congrat Derek. And please, please keep blogging - chemists and chemistry need eloquent voices like yours.

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73. petros on January 12, 2012 8:21 AM writes...

Well done Derek for doing this so long and so well. I've been a regular (daily) visitor for a long time and first stumbled across this when you commented on Ariad's patent sledgehammer approach.

But I bet some eyebrows were raised in Wuppertal when you were at the WDF

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74. Andreas on January 12, 2012 8:34 AM writes...

Derek, thanks a lot for your blog - it has become a trusted source (and regular read) in my life!

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75. SKS on January 12, 2012 8:53 AM writes...

Derek,
I came to this blog as a Med chemist @2007 and was hooked. Sat for a week initially and read through most of your old posts. I have changed fields since but i come back to this everyday. Love the posts, love the comments! Congrats!

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76. LiqC on January 12, 2012 9:18 AM writes...

Congratulations! If your page views were stock performance, you'd be the Apple of blogging.

You can add on your accomplishments list inspiring so many people to get into science blogging. Myself included. Cheers!

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77. Ellen Clark on January 12, 2012 9:52 AM writes...

Congratulations, Dr Lowe. As someone who recruits only PhD and MD candidates and a lot of chemists especially, I learn so much here. I must stay in tune with the industry and your posts keep me updated. You also set a good example for my own blog, which I started a year ago. Thank you.

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78. Stubbie on January 12, 2012 10:00 AM writes...

Congratulations, Derek, on your 10-year anniversary. Your blog rates a main column bookmark on my browser. It's a place I go to for adult conversation on issues near and dear to my heart. Keep up the good work!

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79. MarkySparky on January 12, 2012 10:18 AM writes...

I started reading as a college freshman back in 2003, and have been a regular reader ever since. I credit Derek and the commenting community with preparing me for the ups and downs of grad school. I am about to finish my PhD in Microbiology, and rarely does a week go by that I am not reminded of something I have read here. Definitely helps keep things on perspective...

Thanks.

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80. Anon on January 12, 2012 10:40 AM writes...

I haven't seen a hard copy of any of the journals I read in. . .months? Years? Articles get published online

But, admit it, Derek, you and everyone else print 'em out so as to be able to make notes in the margins and avoid the eye fatigue from computer screens!

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81. Anon on January 12, 2012 10:43 AM writes...

Print journals have looked archaic for some time, and will likely continue their vanishing act. I haven't seen a hard copy of any of the journals I read in. . .months? Years? Articles get published online

But admit it ... you still PRINT OUT those articles to read, like everyone else, so you can make notes in the margins, use a yellow highlighter and avoid the eye strain of computer screens!

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82. Anon on January 12, 2012 10:45 AM writes...

-- and print journals, unlike web sites, don't hang up, causing a person to make a note twice! --

:-)

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83. Hap on January 12, 2012 11:38 AM writes...

Kindle might not be bad for reading journal articles (since Dr. Lowe's book is coming there first, maybe that's what he uses). I'm hesitant to spend $400 on the full-page version unless I know I can get the pdfs on there reliably and read them OK. A tablet might work, but it's sort of power-hungry.

On the other hand, I can't draw on a Kindle screen. That's a downside for me, though I don't know if it outweighs the number of trees I have to kill to read articles.

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84. dddd on January 12, 2012 12:17 PM writes...

Congratulations Derek.

Out of interest, how do you determine which stories are getting more views? No of comments? No of pageviews of the story itself? Homepage counts whilst that story is the top story?

I for one usually only read the most recent stories on the ITP homepage.

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85. Chrispy on January 12, 2012 4:13 PM writes...

Congratulations, Derek!
This is the only blog I read every day. You are inspirational: I'm considering firing up a blog myself on large-molecule drug discovery, which is what I do. You write so much, though -- I think that is one of the reasons this blog is so good is that you are so prolific.

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86. biotechchap on January 12, 2012 4:14 PM writes...

Reading your blog since last 2.5 years and it has been a great learning experience.....thanks and looking forward to gain multiple perspectives in coming decades!!!!!!!!!!!

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87. The Heterocyclist on January 12, 2012 4:25 PM writes...

Congratulations, Derek. I really appreciate how you turn out informative, well-written posts. Frequently, and on top of your day job! Pretty amazing.

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88. idiotraptor on January 12, 2012 8:25 PM writes...

Derek,

I'm in the metro Boston area and have worked for several local biopharma companies. Three years ago a buddy of mine (an analytical chemist) referred me (a PhD biologist) to your blog. After one week of reading your posts and the accompanying string of replies, I was hooked. In the Pipeline is necessary (and entertaining) reading for me. Keep up the fine work. I'll send you an invite to our Spring Barbeque...

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89. medchem on January 12, 2012 10:04 PM writes...

Congratulations and thanks for the great posts.

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90. fuelair on January 13, 2012 12:12 AM writes...

Happy tenth - and thans so much for your blog. Funny, informative, funny, incitefull - and funny to boot. High school chem teacher - introduced to this by a fellow same about 3 yearsa ago - have read through Thing's I won't several times and have introduced many others to you (generally and on the JREF site. My greatest thanks you is for introducing me to Max Gergel (I now have an autographed copy of his second autobiographical book. Looking much forward to your book in hard copy!! :)

All the best, keep up the good work, point out and nail the bastards every chance you get.

Thanks, fuelair

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91. Twoyaks on January 13, 2012 1:49 AM writes...

Happy blogaversary! Many more!

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92. bcpmoon on January 13, 2012 3:53 AM writes...

Herzlichen Glückwunsch zum Jubiläum! Bin seit 2003 dabei und empfehle den Blog jedem, der nicht bei drei auf den Bäumen ist...

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93. Jill U Adams on January 13, 2012 10:17 AM writes...

Congrats and thanks.

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94. Voracious Reader on January 15, 2012 7:45 PM writes...

Derek, You are Thomas Edison, John Ford, and Graham Bell of scientific blogging. I hope that someday you will be awarded the Pulitzer prize for scientific blogging. At my previous company, occassionally I used to hear one of my colleagues say, "I heard about it last week from the blog 'In the Pipeline'."

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95. Dan Spinato on January 30, 2012 3:57 AM writes...

Happy anniversary, though it's belated. It is not all the time that we come across informative, real scientific blogging. More power to you!

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