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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Alzheimer's: The News Is Not Getting Better | Main | Data Handling in Collaborations »

July 26, 2011

Precious Metal Time

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Posted by Derek

What do you want to bet that Huw Davies and co-workers were partly interested in making dihydrofurans here, and mostly interested in having a synthetic sequence that used rhodium, silver, and then gold? Not that I blame them - personally, I'd have gone ahead and done a palladium coupling, a copper-catalyzed Ullmann of some sort, and then found something to reduce with platinum oxide. Go for the record! What is the record, I wonder?

Comments (3) + TrackBacks (0) | Category: Chemical News


COMMENTS

1. Tim McDaniel on July 26, 2011 12:22 PM writes...

"What do you want to be that" -- do you mean "What do you want to bet that"?

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2. S on July 26, 2011 12:41 PM writes...

In a side project I am working on, we are trying to use Pd then Cu, then Pt, then some more Cu all in 2-3 discrete steps. However, I must add the molecular architecture probably warrants this use. ;)

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3. Another Kevin on July 26, 2011 8:24 PM writes...

What, no alkene to make into a diol using osmium tetroxide?

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