« Pfizer's Layoff Dance |
| Pfizer's Brave New Med-Chem World »
May 25, 2011
Getting Rid of Pesky Chirality
A reader sends along this example of a "stereodestructive" synthesis. I have nothing in particular against N-alkylpyrroles, but do we need another route to them so badly that we have to tear up not-so-cheap hydroxyproline to get there, burning up two chiral centers in the process?
Readers are invited to submit other examples from the "wad it up and throw it away" school of chiral synthesis in the comments. . .
+ TrackBacks (0) | Category: Chemical News
POST A COMMENT
- RELATED ENTRIES
- XKCD on Protein Folding
- The 2014 Chemistry Nobel: Beating the Diffraction Limit
- German Pharma, Or What's Left of It
- Sunesis Fails with Vosaroxin
- A New Way to Estimate a Compound's Chances?
- Meinwald Honored
- Molecular Biology Turns Into Chemistry
- Speaking at Northeastern