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About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Eribulin Gets Reviewed, Finally | Main | OCD Linked to the Immune System? »

June 4, 2010

Nativis: Waiting and Seeing

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Posted by Derek

I've been hearing a lot about Nativis since my post the other day, much of it from their CEO, who's sent along quite a bit of information. Two themes that reoccur are that the company is planning to publish on their technologies within the next few months, and that they're planning to file for an IND on their taxane-derived work.

Rather than continue to speculate on what the heck is going on with them, then, I'm going to wait until one or both these events happen. Either of them will provide a lot more data to work with, and either one will require convincing other observers that there's something worthwhile going on. Based on what I've seen, I remain skeptical, but there are always things that I haven't seen. We'll take up the topic again.

Comments (114) + TrackBacks (0) | Category: Snake Oil


COMMENTS

1. alig on June 4, 2010 7:50 AM writes...

If any IRB approves this clinical trial, they should all be fired. It is unethical to treat cancer patients with a placebo when real treatments exist.

Permalink to Comment

2. jasonb on June 4, 2010 8:16 AM writes...

This seems to be the modus operandi of the kooks though. Throw out incredible claims, then when its questioned say that "the real data will be published soon." and we will never hear of it again. Still waiting on LaClaire to publish something supporting his claim to hexacyclinol too, which he said years ago would be out "soon". If a followup to this with any "data" gets written Ill be very surprised.

Permalink to Comment

3. Han Solo chemist on June 4, 2010 8:38 AM writes...

I've flown from one side of this galaxy to the other. I've seen a lot of strange stuff, but I've never seen anything to make me believe there's a "photonic field" that will take the place of real drugs. The data is always "forthcoming". Seems like the new cold fusion to me.

Permalink to Comment

4. John on June 4, 2010 9:35 AM writes...

Derek, this seems much too generous. I'd really appreciate it if you or someone else would call up their science advisors and see whether they read the claims before signing on.

Permalink to Comment

5. CB on June 4, 2010 9:53 AM writes...

No it is much worse than cold fusion or Beneveniste's junk science.

Both cold fusion and Beneviniste's claims at least had a protocol with scientific experiments and a hypothesis that could be tested and scrutinized by other scientists.

Nothing in any of the patents presents any data that lends credence to any of the claims on the Nativis website.

It appears that John T. Butters also ran wavbank, prior nativis, the same type of nonsensical patents are associated with the name. I wonder how that company worked out?

I have found that many companies are selling stock and raising funds based on completely bogus ideas, many of them trade on the pink sheets.

Permalink to Comment

6. EC on June 4, 2010 10:58 AM writes...

It would be great if it worked

or

If it works so well, then it shouldn't be hard to demonstrate

either way let's see the data

Permalink to Comment

7. EC on June 4, 2010 11:08 AM writes...

It would be great if it worked

or

If it works so well, then it shouldn't be hard to demonstrate

either way let's see the data

Permalink to Comment

8. EC on June 4, 2010 11:08 AM writes...

It would be great if it worked

or

If it works so well, then it shouldn't be hard to demonstrate

either way let's see the data

Permalink to Comment

9. liam ondnes on June 4, 2010 12:24 PM writes...

alig nailed it here... these people are, in essence, leveraging the fear and uncertainty associated with serious diseases to extort money from 'investors.' but the investors are not really the concern: hopefully the regulatory agencies crack down on these quacks before they get around to killing people with their useless 'technology' who might otherwise have a chance in a legitimate clinical trial. the investors should demand to see RAW data from double-blind experiments before allowing another dollar of their money to be wasted on this nonsense. that money could actually be put to good use funding legitimate research efforts.

Permalink to Comment

10. geezer on June 4, 2010 12:31 PM writes...

It would be great if you could

just

hit the Post button once

thanks

Permalink to Comment

11. SRC on June 4, 2010 12:34 PM writes...

You are charitable, Derek.

I'll revisit this issue if and when further data become available, but for now, I'll have to go with the text of the patents. And they're impenetrable gobbledy-gook.

So I put this one in the AGW bin unless and until they put up or shut up.

Permalink to Comment

12. liam ondnes on June 4, 2010 1:14 PM writes...

alig nailed it here... these people are, in essence, leveraging the fear and uncertainty associated with serious diseases to extort money from 'investors.' but the investors are not really the concern: hopefully the regulatory agencies crack down on these quacks before they get around to killing people with their useless 'technology' who might otherwise have a chance in a legitimate clinical trial. the investors should demand to see RAW data from double-blind experiments before allowing another dollar of their money to be wasted on this nonsense. that money could actually be put to good use funding legitimate research efforts.

Permalink to Comment

13. Iridium on June 4, 2010 1:48 PM writes...

When I commented to a co-worker about the first post Derek made about Nativis she had the following response, minus the obligatory 'what the heck?!?' type comments: "So if these people need to record photon field signals of APIs for their their 'drugs', what's going to happen when they run out of drugs to record? They're at the mercy of real drug companies to actually discover drugs, do all the development legwork, run the clinical trials, etc."

Granted, there are enough drugs out there to record signals for and re-hash as 'new treatments', but they're never going to develop anything to treat unmet medical needs (unless there whole 'Taxol with no side effects' business is true). All this company is peddling beyond apparent snake oil is extreme versions of 'Me Too' drugs.

Permalink to Comment

14. JasonP on June 4, 2010 1:55 PM writes...

I'm going down there to the site in a little bit to poke around. I'll report what I see.

Permalink to Comment

15. researchfella on June 4, 2010 2:15 PM writes...

@Alig "It is unethical to treat cancer patients with a placebo when real treatments exist."

That's pretty much the case for all oncology clinical studies with new therapies. Typically it's patients who don't respond or no longer respond to all established treatment options who are treated with potential new therapies.

But, anyway, it's sad to give these patients false hope with a supposed photon field treatment.

Permalink to Comment

16. MTK on June 4, 2010 2:16 PM writes...

Jason,

If we don't hear from you by 6 we'll send the hounds.

Permalink to Comment

17. Evorich on June 4, 2010 2:30 PM writes...

Not only do they exploit the need for new technologies, and new cures, they do it by exploiting the fundemental misunderstanding of science and the scientific process that the majority of people. They seem to want to exploit a perceived gray area that in fact does not exist.

Q: why would the relatively upstanding board members sign up? Money??

Permalink to Comment

18. Evorich on June 4, 2010 2:31 PM writes...

Not only do they exploit the need for new technologies, and new cures, they do it by exploiting the fundemental misunderstanding of science and the scientific process that the majority of people. They seem to want to exploit a perceived gray area that in fact does not exist.

Q: why would the relatively upstanding board members sign up? Money??

Permalink to Comment

19. JasonP on June 4, 2010 11:18 PM writes...

OK, would have posted earlier but my connectivity to this web site has been spotty today. No need to send the dogs!

I swung down there at lunch to have a look. I use to work in the area and yes indeed it is an expensive area. Usually only the big guys are here, with the small potato companies in the Sorrento Valley area a little inland.

I walked into the building and was immediately questioned by a Facebook reading security guard who wanted to know my business. Not use to security guards caring quite that much. I said that I was a reporter from 'In the Pipeline with Derek Lowe'...just kidding, I mentioned that I was impressed with Nativis' technology and was interested in getting information on the company and job opportunities. He was quick to answer, almost like he’s done this many times before. He knew about John and Lisa Butters and called into the office. Today only the secretary was there and said I would have to come back another time, where a little later on the second floor of the lobby a concerned woman came out and checked out the scene.

That was all the info I could get from him other than a card. Before I left I took a picture of the sign in front of the building. I also took a quick peek into their very tinted windows. Was not able to see much but it seemed like all I could see was office style tables and lamps, a little bare. Would be surprised if a bunch of research was going on in there.

Go to the link below for my cell phone pic of the front sign, and a scan of the business card the guard gave me.

http://s900.photobucket.com/albums/ac205/JasonP_2010/

Permalink to Comment

20. Sili on June 4, 2010 11:27 PM writes...

their CEO, who's sent along quite a bit of information.
Seriously? He sent their vaporware to a real scientist? So does he have chutzpah, or has he just deceived himself as well? Permalink to Comment

21. Sili on June 4, 2010 11:34 PM writes...

I said that I was a reporter from 'In the Pipeline with Derek Lowe
Derek, you should have business cards made for us to use in cases like this. Citizen reporting!
So I put this one in the AGW bin unless and until they put up or shut up.
Based on this I wouldn't trust you to recognise gobbledegook if it bit you on the nose. Permalink to Comment

22. cnbc on June 4, 2010 11:44 PM writes...

This appears to be an interview with nativis on CNBC. It starts about halfway through the clip. Anyone able to make anything of it from what they show of their lab space?

http://www.theecocapitalist.com/episode1-part3.html

Permalink to Comment

23. Evorich on June 5, 2010 12:42 AM writes...

Jason - thank you so much for the reporting expedition - I'm glad you came back unscathed!

Permalink to Comment

24. Evorich on June 5, 2010 2:37 AM writes...

John - there was a comment by their ex-BMS advisor in one article - he basically just said no-one understood it. Their one phd scientist on their team has disappeared from LinkedIn. I don't think the investors did much dd. I tried contacting them to ask some questions like these. They forwarded my questions to Butters and he forwarded them to his lawyers and cc'd me.I got the feeling that this was a thinly veiled threat.

Permalink to Comment

25. Smitten on June 5, 2010 9:31 AM writes...

There should not be any waiting and seeing. These people should be in jail.

Permalink to Comment

26. John on June 5, 2010 11:10 AM writes...

JasonP: I'm afraid the card scan came out illegible, but we definitely appreciate your efforts.

Permalink to Comment

27. AR on June 5, 2010 12:51 PM writes...

Ha! I’ve enjoyed following the JasonP subterfuge. Sounds like a reality series to me.

Permalink to Comment

28. AR on June 5, 2010 12:52 PM writes...

Ha! I've enjoyed following the JasonP subterfuge. Sounds like a reality series to me.

Permalink to Comment

29. Chemjobber on June 5, 2010 1:03 PM writes...

Awesome, JasonP! Man, I miss that area.

Permalink to Comment

30. Watson on June 5, 2010 5:25 PM writes...

I went to google patents to see what all the hubbub was about. From what I can tell, they have developed a screening methodology where you use known drug ligands attached to micro/nano particles containing a fluorescent moiety and 1-several quantum dots (cadmium compounds) which rotate under an applied magnetic field.

In a sense this is akin to KIMS, just with the application of a magnetic field which induces a rotation by interacting with the quantum dots. One of their claims is that this can be used for screening unknowns based upon their ability to enhance or degrade the resultant measured fluorescence.

Another patent is where it gets hokey for me: namely, feeding the recorded signal back through an electromagnetic coil or series of coils which contains a properly placed patient. This radiation, not the visible fluorescent radiation from the recording experiment, is claimed to have therapeutic affect.

They aren't "magnetizing" water or manufacturing some sort of lasting "field" in water, although the ex-BMS scientist on the video claims that's what they're doing. It seems like they are taking a giant step here and claiming that the electromagnetic radiation observed from the interaction of macromolecules with their screening system is capable of inducing macromolecules to adjust their conformations in the absence of ligand.

I think this is why they chose taxol - they are trying to demonstrate that the influence of this electromagnetic field can either enhance or disrupt(?) tubulin aggregation.

I certainly hope that this is crap, otherwise some entrepreneur is going to patent electromagnetic drugs of abuse which can't be detected by established screening technologies. Then my work is going to get quite a bit more difficult. I'll wait and see, as well.

Permalink to Comment

31. 10kdays on June 5, 2010 7:37 PM writes...

Came across your blog article on Nativis.

JasonP you're retarded; if you want to see images of their bldg and lab just watch the freaking CNBC World show. What a dumbass. Do you think they had cameras watching you? You're photo is probably sitting on an FBI agents desk. What are you a stalker?

Now for a little intelligence, which seems to be lacking on this so very important blog: :/

I did a bit of checking myself, which took me all of 5 minutes; they've been incorporated for 8 years, changed their name from WavBank to Nativis. They've been members of BIO and SoCal BIOCOM for years.

Hey geniuses, another simple search reveals that Nasa Ames Research and Darpa have been trying to do exactly what Nativis is claiming.

Maybe it's all true, maybe not.

Are any of you scientists? Really, I'm serious.

Better yet, are any of you employed? Dork!

Hey Derek, if I was Vertex I would fire your ass and hire someone with half a brain.

I hear WalMart's hiring.

What a piece of shit blog.

Can one of you come over? I need my car washed.


Permalink to Comment

32. JasonP on June 5, 2010 8:39 PM writes...

Dude, 10kdays, can I come over and wash your car please? I always respect guys who make flaming forum posts. It shows a lot of character and bravery.

Your points about the CNBC article are so true. What could I have possibly gained from poking around the site and seeing no scientific equipment, or talking to one of the totally absent scientists there.

Dude I know: you should start your own blog! I'm so there.

Permalink to Comment

33. Nat on June 5, 2010 8:50 PM writes...

Reading the infantile and profane responses from outraged partisans is always the most fun part of these posts about controversial startups and snake-oil salesmen. Hey Derek, can you post about Blacklight Power again? That should be good for several days of laughs.

Regarding the claims of Nativis, I don't know enough about quantum mechanics to even begin to evaluate whether they're lying, confused, or merely delusional, but I have to agree with the commenters who say this sounds an awful lot like a high-tech update of homeopathy. If comment #30 is an accurate summary of that patent, well, I've heard more convincing technobabble on "Star Trek." But screw it, our tax dollars aren't paying for this, so I'd just as soon sit back and enjoy the show.

Permalink to Comment

34. Watson on June 5, 2010 9:40 PM writes...

@Nat

I work in drugs-of-abuse testing, and the analytical technology they describe seems like a new form of bioassay. More specifically, all of the drug screens we used were based on KIMS (kinetic interaction of microparticles in solution).

You don't have to understand the technobabble, but you should be aware that similar technologies to the ones they patented already exist and are used by a majority of the drug-testing industry, as well as by clinical labs around the world.

On the other hand, as I mentioned in my other post, I'll believe the therapeutic claim when I see it.

Permalink to Comment

35. Firma on June 6, 2010 2:25 AM writes...

It seems infantile responses from outraged partisans goes both ways over this story (minus the profane of course).

To be honest the only consistency in these comments is a lack of objectivity and professionalism.

I can't fathom nativis's claims or patents either, but I think Derek's position has been the most reasonable... healthy - even pointed - skepticism is a valued commodity and a respectable position. Witch hunts are not.

In other words, grow up people.

Permalink to Comment

36. Seastar on June 6, 2010 2:53 AM writes...

Just look in to the credentials and past lawsuits/ claims and filings against John and Lisa. Wouldn't give 'em my money!

Permalink to Comment

37. eugene on June 6, 2010 3:43 AM writes...

"I can't fathom nativis's claims or patents either, but I think Derek's position has been the most reasonable... healthy - even pointed - skepticism is a valued commodity and a respectable position. Witch hunts are not."

On the contrary, they are quite easy to fathom. Let me give you an analogy. The claim by the NASA chief that the US can send a manned mission to Mars in the next ten years would invite disbelief from most scientists, and healthy disagreement. The claim by NASA's chief that the US is going to send a manned mission to Alpha Centauri in the next ten years, would invite a very justified witch hunt calling for the chief's head.

There is no reason to entertain someone who says they can walk on water unless they do it right in front of you right then. Then you're just wasting your valuable time. This particular claim is so far on the side of improbable, that it is worth to dismiss it outright and not waste my valuable time except for the humor value.

Permalink to Comment

38. Firma on June 6, 2010 5:11 AM writes...

@Eugene

So you're saying Comer, Dehlinger, Herr, Radich, Yakatan and Jones have all lost their collective minds? That's an equally tall order imho.

That's the weak link in this fast lane to ridicule, for me at least. There appear to be a number of credible individuals involved, and it appears that they are not tacked on names, if they are appearing on cnbc etc.

I'd just as well reserve my own personal judgement until they've published, or until it appears that will not happen. Hot air blows both ways.

*shrug* I get it though, this me too! me too! firing squad /slash/ circus is good for a laugh, that's what blogs are for.

Permalink to Comment

39. Firma on June 6, 2010 5:13 AM writes...

@Seastar

Can you link your findings? After a few quick google searches I'm not sure what you are referring to.

Permalink to Comment

40. Evorich on June 6, 2010 6:50 AM writes...

10Kdays - could you post links to your mention of NASA and DARPA research in these areas?

I couldn't find this technology was being used towards this aim by anyone else.

Also - why are you so angry an abusive?

Permalink to Comment

41. Nat on June 6, 2010 9:23 AM writes...

Watson--

You don't have to understand the technobabble, but you should be aware that similar technologies to the ones they patented already exist and are used by a majority of the drug-testing industry, as well as by clinical labs around the world.

I was referring specifically to the therapeutic claim - the screening methodology sounded reasonable enough.

Permalink to Comment

42. JasonP on June 6, 2010 11:15 AM writes...

About the CNBC show, for those of us who have actually worked in life science labs, it is an easy identifier of BS when the lab is working with multicolored liquids. 99% of life science work is with clear liquids. The only probable colored liquid in that oddly clean and free of clutter lab was the pink cell culture media.

What was that one green with black spots solution the one guy was working on...frog eggs? Xenopus oocyte?

It would be damn funny though if the research turned out legitimate somehow. I wouldn't hold you r breath on that one.

Permalink to Comment

43. Soundbite. on June 6, 2010 12:00 PM writes...

I watched the CNBC show too. If they can do what I think I heard them say they can do.....well, that would be funny.

Has anyone talked with the scientists Yakatan, Comer, Radich for a more thorough "explanation" of what they are up to?

A google of Nativis doesn't provide much. What is known about the CEO or who is backing them?

Permalink to Comment

44. Doglotion on June 6, 2010 1:51 PM writes...

I think I'm going to go with the comments of the International Examiner on this one:

"...the claimed subject-matter contradict the established laws of physics and cannot be performed, therefore they are not industrially applicable..."

www.wipo.int/pctdb/images1/PATENTSCOPE/93/79/3d/00793d.pdf

Permalink to Comment

45. Evorich on June 6, 2010 1:53 PM writes...

All of the lab footage in the CNBC piece seems to have nothing to do with the claimed technology. Everything is clips of people doing animal (pink) and bacterial (plates & green liquid) cell cultures, and then some amusing clips of people watching educational-type animations of cartoon DNA - as if scientists actually do that in the lab!! There's then the similar clip of them explaining, at a high-school level, DNA transcription on a white board - and people are writing it down! Quite funny! This has absolutely nothing to do with their technology or even the drugs they're proposing that their technology can emulate.

Christine Bonzon was the scientist doing a lot of work in a lot of the clips.

It's also hilarious that John Butters continues to speak in gooblydegook throughout the piece. Usually scientists are asked to explain themselves in layman's terms but he's allowed to say crap like "transduces the signal to the dipole solution" and everyone is expected to just "wow - that sounds cool!"

It was like watching a sort of badly advised science clip from disney world or a tv show. In fact, most tv shows these days, E.g. CSI or something, do a better job or showing relevant and accurate scientific clips than these guys did. It's so obviously fake it's unbelievable!

This whole piece was just marketing propaganda for people who aren't scientists.

The only convincing/confusing part of that piece was the interview with Comer. I.e Why is he associating himself so directly with something that he openly admits he doesn't understand?? He even goes on to spout his own form of BS marketing for the technology at the end. Quite sad actually.

Permalink to Comment

46. Sciencegirl on June 6, 2010 3:42 PM writes...

Uh....Just finishing up undergraduate biochemistry and I have to agree with the post that outlines how disneyesque the video is. I am changing careers, going from marketing to science, and I have to say - wow! watching this video made me realize that there is, in fact, an intersection between marketing and science!

Did a little checking and it turns out that neither John nor Lisa Butters has a college degree of any sort, let alone one in a science. John Butters is talking out his backside. He doesn't know jack about cell biology. Impressive marketing blab, but geez! give us all a break. And Lisa Butters background? She used to sell baby clothes at Nordstrom (no joke). They are a couple of shysters. John Butters has been at the game of conning people out of their money for years.

I hope nobody considers giving the man a dime without checking into his past activities. He has left a trail of people to whom he owes money. It's a matter of public record.

Permalink to Comment

47. eugene on June 6, 2010 4:08 PM writes...

"That's the weak link in this fast lane to ridicule, for me at least. There appear to be a number of credible individuals involved, and it appears that they are not tacked on names, if they are appearing on cnbc etc."

Plenty of smart people have been known to be wrong. Besides, I don't care. I consider myself a credible individual when it comes to these matters. And I trust my judgement more and am more affected by it. If you're not even a little qualified to make sense of this company's claim, you are welcome to wait for more evidence. My expert judgement says: ridicule.

If there is something that I don't know that they are hiding, then I wouldn't want to invest in a company that prints such garbage (to cover up intelligent and plausible technological advances) anyways.

Permalink to Comment

48. Silmarillion on June 6, 2010 7:46 PM writes...

10kdays:

Since this is a pharma blog, here are some names you might consider discussing with your doctor:
Cynbalta, Xanax, Zoloft, Prozac, Paxil, Celexa, Valium, Atavan, Klonopin, BuSpar, Remeron, Librium...

Remember that there are adverse side-effects for most of these and you should consult your doctor at once if you experience tightness in the throat or difficulty breathing, eating or drinking. You should also avoid using heavy machinery while taking these medications. You may consider finding less-stressful blogs to follow.

Several Disney-related websites offer games and other diversions which can reduce stress and otherwise provide helpful relaxation. A good hot bath might help too.

Permalink to Comment

49. seastar on June 6, 2010 8:15 PM writes...

@ Firma

tip of the iceberg is here:
case number 97-14972 as well as 96-04825 in King County, Seattle Washington

all a matter of public record.

Permalink to Comment

50. island on June 6, 2010 8:18 PM writes...

Has anyone seen their (John and Lisa) education background or checked it out?

Permalink to Comment

51. Evorich on June 7, 2010 2:19 AM writes...

@ Seastar - I couldn't find anything - could you post links.

Permalink to Comment

52. Lizard_juice on June 7, 2010 5:15 AM writes...

Not sure anyone had read this already, but I guess this is where the money is coming from:

http://www.seattlepi.com/sound/420084_sound93817549.html

30 investors. 30 people conned. Very sad.

I'm guessing 10kdays may have been one of those people and is pretty stressed about his money at the moment.

Permalink to Comment

53. RB Woodweird on June 7, 2010 6:14 AM writes...

I happen to be Her Majesty Elizabeth the Second, by the Grace of God, of Great Britain, Ireland and the British Dominions beyond the Seas Queen, Defender of the Faith, etc. etc.

The data demonstrating this fact is forthcoming.

Permalink to Comment

54. Silmarillion on June 7, 2010 7:32 AM writes...

Queen Elizabeth:

I think it is pretty cool that Royalty would visit Derek's blog. By the way, I've heard about the "Royal Aura." Do you also have a "photon field?" If so, does it look just like you? Does it in any way enable you to be at two places at the same time? Is it kind of like having a clone?

Your loyal subject,
Silmarillion

Permalink to Comment

55. Evorich on June 7, 2010 9:09 AM writes...

Your Majesty, does your royal aura allow you to transduce yourself to a dipole solution and cross my blood-brain-barrier?? This would be fantastic if you could!

Permalink to Comment

56. Hap on June 7, 2010 9:16 AM writes...

I don't think that would be a good idea. Turning your life into "All Of Me" but with the British Royal Family stuck in your head seems like an easy way to go nuts.

Permalink to Comment

57. RB Woodweird on June 7, 2010 10:04 AM writes...

My humble and obedient servants,

We are not amused by the unwarranted audacity of those who would transgress the laws of Nature and God. As the aforementioned Defender of the Faith, we take our responsibility to maintain the tradition of cause and effect seriously. This Nativis situation distresses us, and should these blackguards and knaves set foot in any part of the Empire, they should be forewarned that we have swords which, though they be ceremonial, are sharpened quite regularly.

Elizabeth R*

*(as far as you know)

Permalink to Comment

58. Nativis on June 7, 2010 11:30 AM writes...

Derek,

Thank you again for starting the debate on Nativis’ drug signal therapy. We appreciate your review of our preclinical data and third-party statistical analysis, which we provided you last week. The data speak for themselves. We also appreciate your skepticism and look forward to changing your mind. Many of our science advisory board members had questions early on, but are now fully supportive having seen the statistically significant results of our preclinical testing.

We understand and agree that peer review journals are one of the most important processes for any new technology. Based on the next series of trial results, Nativis anticipates filing an investigative new drug (IND) application for Digitax with the Food and Drug Administration in fall 2010. The new data will also be the foundation for scientific papers on the Nativis platform, which are planned for submission to peer-reviewed journals in the next six months.

Looking forward to providing you with this data and discussing our technology with you again soon.

Sincerely,

John Butters, CEO

Nativis Inc.

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