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May 19, 2010
Pyridines and Dichloromethane
Here's a quick warning for the bench chemists in the crowd: look out if you're making pyridines and using dichloromethane as solvent. This paper reports that the two can react, forming bis-pyridinium compounds - which isn't too surprising, in theory. What's alarming is that this happens at an appreciable rate at room temperature, which is something that I don't think a lot of people knew. I didn't.
As you'd imagine, electron-rich pyridines are the worst offenders. So keep an eye on these guys. . .
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