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April 30, 2010
Rating The Chemical Offerings
I'm working on breaking out the "Rate The Chemical Supplier" posts into a separate area for reference. But here's another interesting contribution in that area. This paper looks at several of the big compound-library suppliers, and evaluates their collections based on compound uniqueness, physical properties, etc.
The take-home? Suppliers seem to have paid more attention to making unique compounds over the last few years, in attempts to stand out from the herd. The percentage of compounds with roughly drug-like properties has increased a bit since 2006 (with Enamine running high and SALOR running low), although the ones with lead-like properties (smaller, etc.) has gone down a touch over the same period (Chembridge and Enamine are probably two of the best in that regard). And the different suppliers actually vary quite a bit in the diversity of their collections: Life Chemicals and AMRI, for example, tend to have larger clusters of similar compounds, while Peakdale and Oakwood have many more singletons. (Whether these are bugs or features depends on what you're looking for). If you're buying large numbers of diverse compounds for screening, the paper's definitely worth a look.
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