Is it just me, or is the fine chemicals supply business getting even more out of hand than usual? I was just talking with a colleague who'd sourced an interesting intermediate, at the (steep!) price of about $900 for a gram. She placed the order and. . .you guessed it, the supplier immediately back-ordered it, saying the price had changed. It took someone from Purchasing to drag the new quote out of them (they apparently wouldn't give it over the phone). Now (to no one's surprise, I'm sure) the material is over $3000/gram, and will have a lead time of weeks.
This sort of thing has gone one for a long time, of course. But my impression is that there's more of it than ever. When the Chinese and ex-Soviet suppliers began to appear some years ago, they were often a pretty cheap source of some unusual compounds. But that's changed.
My belief - and I'll be glad to hear from people who do more compound purchasing than I do - is that the Chinese outfits especially have decided in recent years that they have some real pricing power, and are pushing it to see how far they can get. Add that to the hand-waving don't-you-worry-now aspect of many of their product lists, and you have a recipe for irritation and wasted time. (Another colleague described some of these online catalogs as "things they wish they sold".)
A previous comment on to a post like this listed some suppliers that had been found to be reliable, and I'll reproduce that here, in no particular order: Maybridge, Enamine, Asinex, Key Organics, ChemBridge, Specs, ASDI Biosciences, InterBioScreen, Vitas M Labs, Life Chemicals, Labotest, and TimTec. Suppliers of weirdo outlier compounds that nonetheless tend to come through were Albany Molecular, Chem T&I, Florida Center for Heterocyclic Compounds, and Princeton Biomolecular. I've used many of those folks myself (and have had particular success with Life Chemicals and Specs, as far as availability and purity). Some of these companies are faster to ship than others. But the thing that stands out with all of them is that they have what they say that they have, and what's more, it costs what it says that it costs.
For intermediates, as opposed to final-compound-like structures, I'd say that I've had good dealings with Apollo, Synthonix, Matrix, Pharmacore, Adesis, Tyger, Fluorochem, Oakwood, and Astatech. There are, I'm sure, several other suppliers in this category, and I'd be glad to list more of them after seeing the comments.
But now let's reverse the polarity. What's a blog for if you can't say what you really think? Here, then, is a preliminary blacklist of suppliers. These people either have product listings that overlay poorly with reality, try to jerk you around on the price, take much longer to deliver than their initial estimates, or (lucky you) can do all of these at once. My personal recommendation is to be quite careful with ChemPacific, Uorsys, CTI, Zelinsky, and everyone with the words "Hangzhou" or "Shanghai" in the company name.
Please feel free to add others to the lists. I'll do a consolidated post reflecting everyone's experience - that way, we can give business to deserving companies you might not have worked with before, and we can perhaps shame some others into acting more reasonably.