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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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March 16, 2010

Terra Incognita

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Posted by Derek

I was thinking the other day about the sheer number of reasonable chemical structures that have never been made. Chemical space is famously roomy - that's how we make a living in the drug industry, since we prefer to make things that have never been made before. And it still surprises non-chemists when I tell them that I make new compounds all the time - the feeling, I think, is that anything that's reasonably easy to make surely must have been mined out long ago. Not so. (It's worth remembering, though, that just because something's never been reported doesn't always mean that you can't buy it).

What brought this to mind was a steroid structure that I saw during a presentation. Looking at it like a medicinal chemist, I wondered idly if the carbons in the famous steroid backbone had ever been swapped out much with oxygen or nitrogen atoms. And in a few cases they have (more for oxygen, in some natural products), but for the most part, no. You can drop a tertiary amine into some spots on the steroid framework and immediately come up with no literature hits whatsoever. Many others yield only a handful.

It's worth noting that the partially-aromatized steroids have had some of this kind of work done on them - for example here and here. The aromatic rings give you a bit more of a handle to work with, but even here it's not like the literature is always packed with examples.

So there's as bioactive a scaffold as you could ask for, but many of the simple analogs still haven't been described. To be fair, these azasteroids aren't simple to make, and probably wouldn't have steroid-like activities in many cases. (Their natural receptors sure aren't expecting a basic amine in those spots). But many azasteroids do show biological activities, and I'd be quite surprised if these unknown compounds were pharmacologically inert. It's just that there's been no particular reason to make any of them yet. Chemical space is so huge, and our ability to explore it has been with us for such a relatively short time, that we just haven't gotten around to them yet.

Comments (8) + TrackBacks (0) | Category: The Scientific Literature


COMMENTS

1. Anonymous on March 16, 2010 9:11 AM writes...

Just about germane: years ago Dasent wrote a lovely book "Nonexistent compounds". It's a good way to learn some chemistry.

Permalink to Comment

2. NJBiologist on March 16, 2010 11:09 AM writes...

Y'know, steroids like that might make interesting tools for separating actions at traditional (DNA-binding) and non-traditional (GPCR/unknown) steroid receptors.

Permalink to Comment

3. JasonP on March 16, 2010 6:48 PM writes...

Well, you THINK you make new chemical species every day, but there is no telling what labs have made and are hiding across the world. :)

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4. Jose on March 16, 2010 6:58 PM writes...

Some of those amino-steroids might be in the running for the "Pole of Synthetic Inaccessibility" prize, I think.

Permalink to Comment

5. chemist on March 17, 2010 11:30 AM writes...

Caveat emptor: if you are relying on SciFinder to determine whether or not a structure (or reaction) is known you could be deluding yourself and others. I have held papers in my hand, drawn the structures and SciFinder does not find the compounds or source documents.

(You can sometimes have better success using CASOnLine.)

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6. MoD on March 17, 2010 7:55 PM writes...

Interesting post Derek. Way back (~18 yrs ago - OH MY!) when I was an undergraduate, I was making 16-azasteroids. Why? Because we had some nice methodology that allowed us to. Very interesting molecules, including aromatic pyrrole D-rings. My advisor had some connections, so we ended up sending them to the NCI or NIH for their screening collection. We never wrote a publication so you will not find them using any searches.

Permalink to Comment

7. Cartesian on March 18, 2010 5:38 AM writes...

May be with a new model for atom it will be better in order to discover some new things.

See article 3 part one and two here :

http://eternal-cartesian.blogspot.com/search?updated-min=2009-09-01T00%3A00%3A00-07%3A00&updated-max=2009-10-01T00%3A00%3A00-07%3A00&max-results=19

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8. KY on March 18, 2010 2:25 PM writes...

i believe that Gribble at Dartmouth had been funded to do exactly that a few years ago and came up with CDDO, the analogues which i had to synthesize.

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