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January 21, 2010
An Enzyme Inhibitor You Have Never, Ever, Considered
I promise you that. Take a look at this abstract:
". . .an unappreciated physicochemical property of xenon has been that this gas also binds to the active site of a series of serine proteases. Because the active site of serine proteases is structurally conserved, we have hypothesized and investigated whether xenon may alter the catalytic efficiency of tissue-type plasminogen activator (tPA), a serine protease that is the only approved therapy for acute ischemic stroke today."
They go on to provide evidence that xenon is indeed a tPA inhibitor. And as it turns out, there's more evidence for xenon having a number of physiological effects, and enzyme inhibition has been proposed as one mechanism. Who knew?
Now, there's an SAR challenge. . .
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