« MAGL: A New Cancer Target |
| The Sirtris Compounds: Worthless? Really? »
January 11, 2010
Sure About That?
There was a natural products paper (abstract) that I missed last fall which has finally come out in Bioorganic and Medicinal Chemistry Letters. Let's have a show of hands: how many chemists out there think that this structure is the correct one?
Right. Going back through SciFinder, I don't find any anti-Bredt cyclobutene structures of this sort in the modern era - only speculations about whether or not they could even exist. I hope, for their sake, that the authors have assigned this one correctly, and it certainly would be neat and interesting if they have. But doubts afflict me.
Note - the most recent entry on the (inactive?) med-chem blog "One in Ten Thousand" was a raised eyebrow about this exact paper. Fear not, there's no curse - I'll continue posting. . .
+ TrackBacks (0) | Category: Analytical Chemistry | Chemical News
POST A COMMENT
- RELATED ENTRIES
- The Other Shoe Drops at Ariad
- Exiting Two Therapeutic Areas
- Organizing Research
- Now Novartis-Emeryville?
- BMS Reshuffling
- The Seat of Learning, Indeed
- Compassionate Access: No Good Answer
- Novartis Closing Horsham