Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases.
To contact Derek email him directly: derekb.lowe@gmail.com
Twitter: Dereklowe
5. Johnny Fitz on December 2, 2009 12:00 PM writes...
Wonder if Newton would have been able to get tenure under our present system. I still say neither darwin nor Einstein would have. I also wonder if they would have wanted to.
Thanks for putting this up by the way, I love to read the old stuff, sometimes it motivates me, sometimes it makes me feel a little inadequate though.
Historians have (relatively) recently discovered Newton took quite a bit of credit for discoveries made by Hooke when Hooke died before Newton and could no longer defend his name. There's a pretty good description of their interactions in the book "The Scientists: A History of Science Told Through the Lives of Its Greatest Inventors"
7. Derek Lowe on December 2, 2009 12:29 PM writes...
JH, no argument about Euler - or Gauss, either, for that matter. I'm not enough of a mathematician to say for sure, but I think that there's a good case to add Riemann to that list as well. At any rate, we're most certainly talking about the first row of the big auditorium.
Actually, copyright as we know it today didn't exist until the Statute of Anne in 1709. This would've been protected by the royal charter granted to the Stationers' Company, which, in an effort to suppress the Protestant Reformation, forbid all publishing by other entities. So yeah, this paper predates copyright.
could you give us some insight into this latest Nature paper "Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila"
11. anon the II on December 2, 2009 5:15 PM writes...
to Carmen:
Pleafe don't poft any more articlef like that one. They're very annoying to try to read. It appearf that they had an "s" in their typefetting kit but they refufed to ufe it.
12. bad wolf on December 2, 2009 5:32 PM writes...
anon@11: Don't both articles have the same (antiquated) spelling system? Why complain about only one? Heck, if anyone else has a favorite seventeenth- or eighteenth-century journal article they'd like to share, i'd love to see it.
And didn't he waste most of his later years pursuing alchemy?
He was pretty good at getting forgerers executed.
And he did hella job wiping all trace of Hooke from the historybooks (apropos of scientists being people, too. Not necessarily nice people. And yet apples still fall to the ground.)
Riemann was a genius, yes. Another life cut tragically short.
Newton may have had precedence, but we all use Leibnitz' system now - even the English. It's also worth remembering that none of these people worked in a vacuum: Fermat and Descartes did the ground work of analytical geometry to pave the way. And they along with many others were nibbling at the edges of calculus before N&L. But the final synthesis and understanding was all Newton and Leibniz, yes.
1. petros on December 2, 2009 10:31 AM writes...
And didn't he waste most of his later years pursuing alchemy?
Permalink to Comment2. Rhenium on December 2, 2009 10:41 AM writes...
From page 3080
"Amidst these thoughts I was forced from Cambridge by the intervening Plague, and it was more then two years before I proceeded further."
I don't know it his granting agency will stand for a two year hiatus in the work, plague or no plague...
Permalink to Comment3. JH on December 2, 2009 10:52 AM writes...
Euler, if anyone, was the real deal.
Permalink to Comment4. RB Woodward on December 2, 2009 11:44 AM writes...
My favorite take on Sir Isaac is the Baroque Cycle trilogy by Stephenson.
Also, it is alleged that the famous "If I have seen further, it is by standing on the shoulders of giants" was a cheap shot at the very short Hooke.
Permalink to Comment5. Johnny Fitz on December 2, 2009 12:00 PM writes...
Wonder if Newton would have been able to get tenure under our present system. I still say neither darwin nor Einstein would have. I also wonder if they would have wanted to.
Permalink to CommentThanks for putting this up by the way, I love to read the old stuff, sometimes it motivates me, sometimes it makes me feel a little inadequate though.
6. Tok on December 2, 2009 12:24 PM writes...
Historians have (relatively) recently discovered Newton took quite a bit of credit for discoveries made by Hooke when Hooke died before Newton and could no longer defend his name. There's a pretty good description of their interactions in the book "The Scientists: A History of Science Told Through the Lives of Its Greatest Inventors"
Permalink to Comment7. Derek Lowe on December 2, 2009 12:29 PM writes...
JH, no argument about Euler - or Gauss, either, for that matter. I'm not enough of a mathematician to say for sure, but I think that there's a good case to add Riemann to that list as well. At any rate, we're most certainly talking about the first row of the big auditorium.
Permalink to Comment8. TAC on December 2, 2009 12:36 PM writes...
Actually, copyright as we know it today didn't exist until the Statute of Anne in 1709. This would've been protected by the royal charter granted to the Stationers' Company, which, in an effort to suppress the Protestant Reformation, forbid all publishing by other entities. So yeah, this paper predates copyright.
Permalink to Comment9. Carmen on December 2, 2009 1:04 PM writes...
What a treat-I'm partial to Edmund Stone's "Account of the Success of the Bark of the Willow in the Cure of Agues", m'self.
Permalink to Commenthttp://rstl.royalsocietypublishing.org/content/53/195.full.pdf
10. anonym on December 2, 2009 4:44 PM writes...
Hey Derek,
could you give us some insight into this latest Nature paper "Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila"
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08619.html
Permalink to Comment11. anon the II on December 2, 2009 5:15 PM writes...
to Carmen:
Pleafe don't poft any more articlef like that one. They're very annoying to try to read. It appearf that they had an "s" in their typefetting kit but they refufed to ufe it.
Permalink to Comment12. bad wolf on December 2, 2009 5:32 PM writes...
anon@11: Don't both articles have the same (antiquated) spelling system? Why complain about only one? Heck, if anyone else has a favorite seventeenth- or eighteenth-century journal article they'd like to share, i'd love to see it.
Permalink to Comment13. dearieme on December 2, 2009 7:09 PM writes...
Newton must be the only man who has been a top-flight mathematician, and experimental physicist, and theoretical physicist. Or not?
By repute, the pictures Einstein displayed on his wall were of Newton, Clerk Maxwell and Faraday.
Permalink to Comment14. Sili on December 2, 2009 7:55 PM writes...
He was pretty good at getting forgerers executed.And he did hella job wiping all trace of Hooke from the historybooks (apropos of scientists being people, too. Not necessarily nice people. And yet apples still fall to the ground.)
Riemann was a genius, yes. Another life cut tragically short.
Newton may have had precedence, but we all use Leibnitz' system now - even the English. It's also worth remembering that none of these people worked in a vacuum: Fermat and Descartes did the ground work of analytical geometry to pave the way. And they along with many others were nibbling at the edges of calculus before N&L. But the final synthesis and understanding was all Newton and Leibniz, yes.
It's not an f!
Permalink to Comment15. alig on December 2, 2009 8:36 PM writes...
Why in the title and abstract does he talk about colors, but in the body of the paper talk about colours?
Permalink to Comment16. Jose on December 3, 2009 4:19 AM writes...
"Although it's a very tiny genome, it's much more complicated than we thought."
Good luck with genomics and GWAS, kiddies!
http://www.newscientist.com/article/dn18206-simple-bacterium-shows-surprising-complexity.html
Permalink to Comment17. David on December 3, 2009 2:01 PM writes...
As to 15.
Color is an American Spelling - colour is a British and Canadian spelling
As to 11:
see: http://en.wikipedia.org/wiki/Long_s
Permalink to Comment18. alig on December 3, 2009 4:40 PM writes...
David,
Really? In 1671 he choose to use the American spelling in the title of his paper?
Permalink to Comment19. Jet on December 3, 2009 9:00 PM writes...
I teach, and asked a group of third graders what fruit is most often associated with Isaac Newton. Several students shouted out "the fig!"
Permalink to Comment20. David on December 5, 2009 4:35 PM writes...
to: Alig
Partly right, insofar as I could tell Mr. Newton used colour. The abstract author - who may or may not have been Mr. Newton chose color. The use of color in English spelling was not unknown. The split happened sometime later.
see:
http://en.wikipedia.org/wiki/American_and_British_English_spelling_differences#-our.2C_-or
BTW - I do not rely on Wikipaedia but for a quick, non-substantive question it will do.
Permalink to Comment