Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases.
To contact Derek email him directly: derekb.lowe@gmail.com
Twitter: Dereklowe
While I'm putting up odd chemical structures today, I thought I'd add this one, Alasmontamine A, from the latest Organic Letter preprint stream. Natural products scare me:
Anyone who wants to take a crack at this one synthetically, you just go right ahead without me. It is pretty much a dimer, though, so it's only about half as awful as it looks. Which is still enough. It doesn't seem to have much biological activity, but if you can sell it as something to do with green chemistry, nanotech, or alternative energy, you should be able to round up some money, right?
1. David P on November 23, 2009 12:57 PM writes...
I think I'll pass on this one too.
Sure it is almost a dimer, but a horrendous place to link together, into an iminium?!
You could spend many years on this only to find out that they got that initial assignment wrong.
But you would probably find some pretty interesting chemistry along the way...
Permalink to Comment2. startup on November 23, 2009 1:04 PM writes...
You had me at "crack".
Permalink to Comment3. Hap on November 23, 2009 1:06 PM writes...
I'm thinking Overman might be interested, or maybe Smith, if they're still working.
By the standard theory, this is at least eleven years of thesis work (three years + one per nitrogen). Better get cracking.
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