Corante

About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Emolecules
ChemSpider
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
PubChem
Not Voodoo
DailyMed
Druglib
Clinicaltrials.gov

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
Kilomentor
A New Merck, Reviewed
Liberal Arts Chemistry
Electron Pusher
All Things Metathesis
C&E News Blogs
Chemiotics II
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
BBSRC/Douglas Kell
ChemBark
Realizations in Biostatistics
Chemjobber
Pharmalot
ChemSpider Blog
Pharmagossip
Med-Chemist
Organic Chem - Education & Industry
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
SimBioSys
The Curious Wavefunction
Natural Product Man
Fragment Literature
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Business|Bytes|Genes|Molecules
Eye on FDA
Chemical Forums
Depth-First
Symyx Blog
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa


Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
FuturePundit
Aetiology
Gene Expression (I)
Gene Expression (II)
Sciencebase
Pharyngula
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
Cosmic Variance
Biology News Net


Medical Blogs
DB's Medical Rants
Science-Based Medicine
GruntDoc
Respectful Insolence
Diabetes Mine


Economics and Business
Marginal Revolution
The Volokh Conspiracy
Knowledge Problem


Politics / Current Events
Virginia Postrel
Instapundit
Belmont Club
Mickey Kaus


Belles Lettres
Uncouth Reflections
Arts and Letters Daily
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Autism and Vaccines: Boiling Over Yet Again | Main | A Cure for the Common Cold? Don't. . .Ah, Hold Your Breath »

February 12, 2009

Want A Hard Disease Target? Try Lupus

Email This Entry

Posted by Derek

Just ask La Jolla Pharmaceuticals, whose small stock is down about 90 per cent on the bad news. They follow a distinguished list of wipeouts in this area. Immunology is hard.

Comments (8) + TrackBacks (0) | Category: Clinical Trials


COMMENTS

1. atphan on February 12, 2009 2:09 PM writes...

As Gregory House always says, "It's never Lupus"...

On another note, living in La Jolla and knowing many researchers already hit by downsizing at various local companies, this is sobering news.

Permalink to Comment

2. Hap on February 12, 2009 2:57 PM writes...

Maybe not as hard as running a company specializing in immunology. It seems about as profitable as specializing in electrical work in rainstorms while wearing aluminum foil and covered in napalm.

Permalink to Comment

3. Anon-e on February 12, 2009 5:29 PM writes...

"Maybe not as hard as running a company specializing in immunology"

--poor Dynavax, t'was good while it lasted.

Permalink to Comment

4. The Inorganic Gardener on February 13, 2009 8:58 AM writes...

Whilst I'm disappointed (as a lupus patient myself), I'm not surprised. I think SLE is one of the diseases that'll never have a "proper" treatment as it is, by definition, so multifaceted and complex and virtually every patient has different symptoms. It probably needs reclassifying into multiple different diseases - which then might mean they can be targeted better by the drugs companies?

tig

Permalink to Comment

5. Pfizerite on February 14, 2009 3:03 PM writes...

As the patient pool gets smaller and smaller the interest by pharma in the disease gets less and less

Permalink to Comment

6. Sili on February 15, 2009 6:56 AM writes...

How related are Lupus and Psoriasis?

Permalink to Comment

7. Jonadab the Unsightly One on February 16, 2009 7:41 AM writes...

Frankly, if they could just figure out how to reliably *diagnose* Lupus, that would be progress.

Permalink to Comment

8. 3+speckled on February 19, 2009 11:25 PM writes...

No need to be so glum. The failures of late were only relative. The mycophenolate mofetil trials showed equal efficacy with cyclophosphamide which was a failure as far as the FDA was concerned but was great news for rheumatologists. The rituximab bust was a big surprise but most agree that the study was a set up for failure. The ongoing lupus nephritis study, with more easily studied objectives, will hopefully bring better news. I'm pretty happy with just mycophenolate mofetil. Rituximab would make me giddy.

Permalink to Comment

POST A COMMENT




Remember Me?



EMAIL THIS ENTRY TO A FRIEND

Email this entry to:

Your email address:

Message (optional):




RELATED ENTRIES
XKCD on Protein Folding
The 2014 Chemistry Nobel: Beating the Diffraction Limit
German Pharma, Or What's Left of It
Sunesis Fails with Vosaroxin
A New Way to Estimate a Compound's Chances?
Meinwald Honored
Molecular Biology Turns Into Chemistry
Speaking at Northeastern