Corante

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Derek Lowe
Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com

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July 1, 2008

Leaving Comments: A Fix

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Posted by Derek

I know that a lot of people have been having trouble leaving comments here over the past few weeks, with plenty of "Too Many Comments" error messages coming up. I see from today's comment thread that there's a brute-force fix for this - deleting the cookie that this site leaves.

In Firefox, you can do that by going to Preferences, then Privacy, then Show Cookies. Find the "Corante.com" one and kill it - here's hoping that fixes the problem and that it doesn't show up again!

Comments (7) + TrackBacks (0) | Category: Blog Housekeeping


COMMENTS

1. Daniel Newby on July 1, 2008 1:20 PM writes...

If this comment appears, then the fix works.

Permalink to Comment

2. Anonymous BMS Researcher on July 2, 2008 6:54 AM writes...

In Firefox 2.0.0.15 it's Tools/Options/Show Cookies

In MSIE it is more complicated. Here are the directions from its help pages:

To delete a single cookie

In Internet Explorer, click the Tools button, and then click Internet Options.
On the General tab, under Browsing history, click Settings.
Click the View files button.
Click the Name column heading to sort all the files alphabetically, and then scroll down until you see files that begin with the prefix Cookie:. All cookies will have that prefix, and they usually contain the name of the website that created the cookie.
Right-click the cookie you want to delete, click Delete, and then click Yes.
Close the window that contains the list of files, and then click OK twice to return to Internet Explorer.

Permalink to Comment

3. Ger on July 2, 2008 7:01 AM writes...

Derek, would like to hear your comments and other readers, on the story by Ed Silverman of Pharmalot and the comments by readers, on Dr. Edward Tobinick (Dermatologist) and his alzheimer's claims and other practices.

http://www.pharmalot.com/2008/07/enbrel-alzheimers-and-a-controversial-doctor/
Enbrel, Alzheimer’s And A Controversial Doctor

Permalink to Comment

4. Anonymous Big Pharma Researcher on July 2, 2008 7:58 AM writes...

3. Ger on July 2, 2008 7:01 AM wrote:...

> Derek, would like to hear your comments and other
> readers... on Dr. Edward Tobinick (Dermatologist)
> and his alzheimer's claims and other practices.

I don't work on AD, though I know a number of people who do. I can say this much: the pharmalot piece seems on its face to be reasonably well balanced. My gut feeling is, this bears many earmarks of pathological science -- but even if the odds on there being something to this are 100 to one against (which is how I would bet) -- the cost of testing it seems very small compared to the potential benefits. Therefore, either the folks at Amgen are idiots or they have information I don't have showing the idea is not worth pursuing.

On the pharmalot blog a number of people with strong views in favor of Dr. T's work are harshly critical of those who point out anecdotal evidence is bad science. The history of medicine is FULL of treatments, eventually proven worthless or even harmful, that everybody once thought to be valuable based on anecdotal evidence. Anybody who has been in pharma research for very long has seen many a cherished hypothesis that seemed plausible on mechanistic grounds and was supported by early results go down in flames once it was given a proper trial.

Permalink to Comment

5. Hap on July 2, 2008 11:49 AM writes...

Um, the words "single-patient trial" do not inspire confidence in the work.

Permalink to Comment

6. Hap on July 3, 2008 3:34 PM writes...

Anon. BMS. R.,

The IE version of the fix seems to work. Thank you.

Permalink to Comment

7. Ian Musgrave on July 3, 2008 10:18 PM writes...

The fix in Firefox works.

Permalink to Comment

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