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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« The Gates Foundation: Dissatisfied With Results? | Main | More Pfizer Layoffs? »

July 1, 2008

Leaving Comments: A Fix

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Posted by Derek

I know that a lot of people have been having trouble leaving comments here over the past few weeks, with plenty of "Too Many Comments" error messages coming up. I see from today's comment thread that there's a brute-force fix for this - deleting the cookie that this site leaves.

In Firefox, you can do that by going to Preferences, then Privacy, then Show Cookies. Find the "Corante.com" one and kill it - here's hoping that fixes the problem and that it doesn't show up again!

Comments (11) + TrackBacks (0) | Category: Blog Housekeeping


COMMENTS

1. Daniel Newby on July 1, 2008 1:20 PM writes...

If this comment appears, then the fix works.

Permalink to Comment

2. Anonymous BMS Researcher on July 2, 2008 6:54 AM writes...

In Firefox 2.0.0.15 it's Tools/Options/Show Cookies

In MSIE it is more complicated. Here are the directions from its help pages:

To delete a single cookie

In Internet Explorer, click the Tools button, and then click Internet Options.
On the General tab, under Browsing history, click Settings.
Click the View files button.
Click the Name column heading to sort all the files alphabetically, and then scroll down until you see files that begin with the prefix Cookie:. All cookies will have that prefix, and they usually contain the name of the website that created the cookie.
Right-click the cookie you want to delete, click Delete, and then click Yes.
Close the window that contains the list of files, and then click OK twice to return to Internet Explorer.

Permalink to Comment

3. Ger on July 2, 2008 7:01 AM writes...

Derek, would like to hear your comments and other readers, on the story by Ed Silverman of Pharmalot and the comments by readers, on Dr. Edward Tobinick (Dermatologist) and his alzheimer's claims and other practices.

http://www.pharmalot.com/2008/07/enbrel-alzheimers-and-a-controversial-doctor/
Enbrel, Alzheimer’s And A Controversial Doctor

Permalink to Comment

4. Anonymous Big Pharma Researcher on July 2, 2008 7:58 AM writes...

3. Ger on July 2, 2008 7:01 AM wrote:...

> Derek, would like to hear your comments and other
> readers... on Dr. Edward Tobinick (Dermatologist)
> and his alzheimer's claims and other practices.

I don't work on AD, though I know a number of people who do. I can say this much: the pharmalot piece seems on its face to be reasonably well balanced. My gut feeling is, this bears many earmarks of pathological science -- but even if the odds on there being something to this are 100 to one against (which is how I would bet) -- the cost of testing it seems very small compared to the potential benefits. Therefore, either the folks at Amgen are idiots or they have information I don't have showing the idea is not worth pursuing.

On the pharmalot blog a number of people with strong views in favor of Dr. T's work are harshly critical of those who point out anecdotal evidence is bad science. The history of medicine is FULL of treatments, eventually proven worthless or even harmful, that everybody once thought to be valuable based on anecdotal evidence. Anybody who has been in pharma research for very long has seen many a cherished hypothesis that seemed plausible on mechanistic grounds and was supported by early results go down in flames once it was given a proper trial.

Permalink to Comment

5. Hap on July 2, 2008 11:49 AM writes...

Um, the words "single-patient trial" do not inspire confidence in the work.

Permalink to Comment

6. Hap on July 3, 2008 3:34 PM writes...

Anon. BMS. R.,

The IE version of the fix seems to work. Thank you.

Permalink to Comment

7. Ian Musgrave on July 3, 2008 10:18 PM writes...

The fix in Firefox works.

Permalink to Comment

8. Felicia on September 25, 2008 6:37 PM writes...

To: 4. Anonymous Big Pharma Researcher:

I would like to comment about the Pharmalot Blog. I am one of the ones posting that the treatment works, since it has helped my Mom. If you read the posts again, you will see that we are not saying that Anecdotal Evident AGAINST the treatment is bad science, we're saying that we have anectdotal evidence that it does work, and nobody's listening. Also, there are plenty of publications, and now a study by the NIA/NIH (at the ICAD 2008)that has proven the TNF inhibitor theory to be valid against Alzheimer's. Many of us who have had to deal with Ger on other blogs believe his biased copy and paste comments are for his own gain, from a competing pharmaceutical company, namely Elan. My reason for the posts is so that my Mom can keep receiving the treatments, which since we've started have helped her maintain for 7 months now...even through major surgery (colectomy) this last July. Please don't help Ger stop people from believing...it's too important for us caregivers.

Felicia
famc17 (at) yahoo.com

Permalink to Comment

9. globalstay on September 28, 2008 1:22 AM writes...

german boat all sun me trust vacant yahoo

Permalink to Comment

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Permalink to Comment

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Permalink to Comment

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