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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

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February 5, 2008

Room At The Bottom, For Sure

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Posted by Derek

team%20image.jpg

Commenting appears to still be hosed around here, which is a shame, because I have some ask-the-readership posts stacked up. Writing posts under these conditions feels like shouting into a void! I hope things will be fixed soon, but it's quite a tangle behind the scenes.

Time is short today, at any rate, so here's a link to an image that I found simultaneously exciting and unnerving. There's a large project going on to make the world's best electron microscope, through several simultaneous improvements in the electron beam's shape and brightness, refinement of the detectors, damping vibrations in the sample stage, and so on.

So here's the latest. Those are two gold crystalline domains meeting each other at the corner - and those ping-pong balls are the gold atoms. You can clearly see them arranging to meet each other's packing structure at the interface, and if you look to the edges you can see some depth data as well. Those resolutions (well below one angstrom) are real, by the way, and the damn instrument is only about half done.

The group reports that when they scan sample multiple times, they can see individual gold atoms moving around between images. The next steps will include moving to lower-energy electrons for use in biological samples, and I can't even guess what we'll see then. More on the project here.

Comments (1) + TrackBacks (0) | Category: General Scientific News


COMMENTS

1. TNC on February 7, 2008 12:32 AM writes...

I don't know if anyone else had this experience, but I found this picture deeply unsettling, as if I was not meant to see it.

At the same time, it's incredibly cool and should lead to advances that we cannot imagine.

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