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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

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« Holiday Break | Main | You Do The Easy Stuff; I'll Do the Easier »

November 21, 2007

Synthetic Prep of the Day: Chocolate Pecan Pie

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Posted by Derek

I've had several requests, so here we go. This is a slightly modified version of Craig Claiborne's recipe in the New York Times Cookbook. He was a Southerner himself, Claiborne, so he knew his pecan pie:

Melt 2 squares (2 oz.) baking chocolate with 3 tablespoons butter in a microwave or double boiler. Combine 1 cup corn syrup and 3/4 cup sugar in a saucepan and bring to boil for 2 minutes, then mix the melted chocolate and butter into it. Meanwhile, in a large bowl, beat three eggs, then slowly add the chocolate mixture to them, stirring vigorously (you don't want to scramble 'em with the hot chocolate goop).

Add one teaspoon of vanilla, and mix in about 1 1/2 cups of broken-up pecans. You can push that to nearly two cups and still get the whole mixture into a deep-dish pie shell, and I recommend going heavy on the nuts, since the pecan/goop ratio is one thing that distinguishes a home-made pie. Bake for about 45 minutes at 375, and let cool completely before you attack it. Note that this thing has an extremely high energy density - it's not shock-sensitive or anything, but make the slices fairly small.

Comments (8) + TrackBacks (0) | Category: Blog Housekeeping


1. milkshake on November 21, 2007 4:58 PM writes...

Whats the yield on this procedure?

I love pecan pies but I never make one for myself: the same problem as with these giant turkeys, one feeds an army. Two slices of a hefty pie washed down with beer and one struggles to hold his eyes open even without the turkey.

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2. Chris on November 21, 2007 5:27 PM writes...

Derek, I'm looking for a good coconut cream pie recipe. Can you hook me up? :-)

Thanks for this recipe - I think I'll try it out.

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3. Paul on November 21, 2007 7:10 PM writes...

My wife loves pecan pie, and chocolate, so she'd probably love this, but recently she was diagnosed with diverticulosis and is reluctant to eat nuts. There's this notion that seeds and nuts in the diet could complicate the condition, but do you know if this is evidence-based? It seemed like a medical superstition to me.

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4. Chemgeek on November 21, 2007 9:54 PM writes...

I'm not sure this writeup follows the ACS style guide :)

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5. qetzal on November 22, 2007 11:42 AM writes...


I'm guessing elemental analysis would be very close to C6H12O6.


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6. befuddled on November 22, 2007 3:56 PM writes...

I always like to add a little bourbon or dark rum (I like Myers best) to my chocolate pecan pie filling before putting in into the shell. Bourbon also works well with regular pecan pie.

Happy Thanksgiving!

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7. Gene on November 23, 2007 12:04 AM writes...

I can't wait till you're unemployed again. You're such a traitor.

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8. Ralph (ZZ) on November 28, 2007 10:48 AM writes...

I talked with toxicology, they are interested in doing some dose range tests.


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