Corante

About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Emolecules
ChemSpider
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
PubChem
Not Voodoo
DailyMed
Druglib
Clinicaltrials.gov

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
Kilomentor
A New Merck, Reviewed
Liberal Arts Chemistry
Electron Pusher
All Things Metathesis
C&E News Blogs
Chemiotics II
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
BBSRC/Douglas Kell
ChemBark
Realizations in Biostatistics
Chemjobber
Pharmalot
ChemSpider Blog
Pharmagossip
Med-Chemist
Organic Chem - Education & Industry
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
SimBioSys
The Curious Wavefunction
Natural Product Man
Fragment Literature
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Business|Bytes|Genes|Molecules
Eye on FDA
Chemical Forums
Depth-First
Symyx Blog
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa


Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
FuturePundit
Aetiology
Gene Expression (I)
Gene Expression (II)
Sciencebase
Pharyngula
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
Cosmic Variance
Biology News Net


Medical Blogs
DB's Medical Rants
Science-Based Medicine
GruntDoc
Respectful Insolence
Diabetes Mine


Economics and Business
Marginal Revolution
The Volokh Conspiracy
Knowledge Problem


Politics / Current Events
Virginia Postrel
Instapundit
Belmont Club
Mickey Kaus


Belles Lettres
Uncouth Reflections
Arts and Letters Daily
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Holiday Break | Main | You Do The Easy Stuff; I'll Do the Easier »

November 21, 2007

Synthetic Prep of the Day: Chocolate Pecan Pie

Email This Entry

Posted by Derek

I've had several requests, so here we go. This is a slightly modified version of Craig Claiborne's recipe in the New York Times Cookbook. He was a Southerner himself, Claiborne, so he knew his pecan pie:

Melt 2 squares (2 oz.) baking chocolate with 3 tablespoons butter in a microwave or double boiler. Combine 1 cup corn syrup and 3/4 cup sugar in a saucepan and bring to boil for 2 minutes, then mix the melted chocolate and butter into it. Meanwhile, in a large bowl, beat three eggs, then slowly add the chocolate mixture to them, stirring vigorously (you don't want to scramble 'em with the hot chocolate goop).

Add one teaspoon of vanilla, and mix in about 1 1/2 cups of broken-up pecans. You can push that to nearly two cups and still get the whole mixture into a deep-dish pie shell, and I recommend going heavy on the nuts, since the pecan/goop ratio is one thing that distinguishes a home-made pie. Bake for about 45 minutes at 375, and let cool completely before you attack it. Note that this thing has an extremely high energy density - it's not shock-sensitive or anything, but make the slices fairly small.

Comments (8) + TrackBacks (0) | Category: Blog Housekeeping


COMMENTS

1. milkshake on November 21, 2007 4:58 PM writes...

Whats the yield on this procedure?

I love pecan pies but I never make one for myself: the same problem as with these giant turkeys, one feeds an army. Two slices of a hefty pie washed down with beer and one struggles to hold his eyes open even without the turkey.

Permalink to Comment

2. Chris on November 21, 2007 5:27 PM writes...

Derek, I'm looking for a good coconut cream pie recipe. Can you hook me up? :-)

Thanks for this recipe - I think I'll try it out.

Permalink to Comment

3. Paul on November 21, 2007 7:10 PM writes...

My wife loves pecan pie, and chocolate, so she'd probably love this, but recently she was diagnosed with diverticulosis and is reluctant to eat nuts. There's this notion that seeds and nuts in the diet could complicate the condition, but do you know if this is evidence-based? It seemed like a medical superstition to me.

Permalink to Comment

4. Chemgeek on November 21, 2007 9:54 PM writes...

I'm not sure this writeup follows the ACS style guide :)

Permalink to Comment

5. qetzal on November 22, 2007 11:42 AM writes...

@Chemgeek:

I'm guessing elemental analysis would be very close to C6H12O6.

;-)

Permalink to Comment

6. befuddled on November 22, 2007 3:56 PM writes...

I always like to add a little bourbon or dark rum (I like Myers best) to my chocolate pecan pie filling before putting in into the shell. Bourbon also works well with regular pecan pie.

Happy Thanksgiving!

Permalink to Comment

7. Gene on November 23, 2007 12:04 AM writes...

I can't wait till you're unemployed again. You're such a traitor.

Permalink to Comment

8. Ralph (ZZ) on November 28, 2007 10:48 AM writes...

I talked with toxicology, they are interested in doing some dose range tests.

Zz

Permalink to Comment

POST A COMMENT




Remember Me?



EMAIL THIS ENTRY TO A FRIEND

Email this entry to:

Your email address:

Message (optional):




RELATED ENTRIES
Scripps Update
What If Drug Patents Were Written Like Software Patents?
Stem Cells: The Center of "Right to Try"
Speaking of Polyphenols. . .
Dark Biology And Small Molecules
How Polyphenols Work, Perhaps?
More On Automated Medicinal Chemistry
Scripps Merging With USC?