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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

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In the Pipeline

« The Race Is On | Main | Where Do All The Chemicals Go? »

November 14, 2006


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Posted by Derek

Just a few days after I commented on the troubles that Isis Pharmaceuticals has had developing antisense DNA therapies, they've popped up with impressive clinical cardiovascular clinical data. Their latest hope, ISIS 301302, has shown some strong LDL-lowering effects, both as a single agent and in combination with statin therapy.

It's aimed at the production of a key LDL-transporting lipoprotein, apoB-100, which target the company correctly describes as "undruggable" through standard med-chem approaches. Of course, the RNA people are hot on its trail, too (these guys, for example). It's a good opportunity for these approaches, since the protein is of clear biochemical importance, and the site of its synthesis is in the liver and gut wall. Those, of course, are the first tissues that an oral drug sees, and (in the case of many antisense and RNAi attempts) the last ones, too. Going after something that lives there is a good strategy.

On a different topic, welcome more additions to the blogroll, such as Totally Medicinal, a med-chem blogger who's concentrating on the synthetic chemistry end of things. And there's Xcovery, a good kinase-o-centric site for those who can't get enough of 'em.

We now return you to our regularly scheduled site closure, already in progress. I've started a new category, "Closing Time", where my posts on that topic will go. There are a lot of odd blogworthy issues and loose ends associated with shutting down an operation like this. I'll be writing on them in the coming weeks, since many people will (fortunately) not have experienced the process firsthand.

Comments (6) + TrackBacks (0) | Category: Blog Housekeeping | Cardiovascular Disease


2. SP on November 14, 2006 3:54 PM writes...

Are you guys going to be having a fire sale? I know people who might be interested in picking up equipment.

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3. New Prof on November 14, 2006 5:24 PM writes...

I would definitely be interested in some equipment! If you goes are going to have a sell-off, drop me a line.

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4. milkshake on November 14, 2006 7:15 PM writes...

"I would definitely be interested in some equipment!" is cute. It is like leaning over a terminal patient and whispering softly "I would definitely be interested in your wife"

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5. Luke on November 14, 2006 8:48 PM writes...

OMG Milkshake! That is too funny! Sad, but true.

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6. Harry on November 15, 2006 9:00 AM writes...

LOL Milkshake, sad but true indeed! And I'd be interested in any equipment, too. I've actually gotten some pretty good stuff from industrial lab closeouts- but nowadays most firms hire a company to liquidate the equipment for them and the liquidator ends up capturing a lot of the saving.

I've also seen beautiful glassware tossed into the dumpster because the liquidator didn't want to bother with packing it for transport.

Hope things work out for you Derek, and please keep us up to date on the Magical Mystery Project.

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