Corante

About this Author
Derek Lowe
Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Emolecules
ChemSpider
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
PubChem
Not Voodoo
DailyMed
Druglib
Clinicaltrials.gov

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
MedChem Buzz
Kilomentor
On Pharma
A New Merck, Reviewed
Liberal Arts Chemistry
One in Ten Thousand
Electron Pusher
Periodic Tabloid
All Things Metathesis
C&E News Blog
Propter Doc
Chemiotics II
The Chemical Notebook
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
Chirality
BBSRC/Douglas Kell
ChemBark
Drug Discovery Opinion
Realizations in Biostatistics
Chemjobber
Pharmalot
WSJ Health Blog
ChemSpider Blog
Pharmagossip
Med-Chemist
Organic Chem - Education & Industry
Useful Chemistry
Chiral Jones
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
SimBioSys
The Curious Wavefunction
Natural Product Man
Totally Synthetic
Fragment Literature
The F- Blog
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Carbon-Based Curiosities
Experimental Error
Business|Bytes|Genes|Molecules
Eye on FDA
Sigma-Aldrich ChemBlogs
Chemical Forums
Depth-First
Symyx Blog
P212121
ChemCafe
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa


Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
FuturePundit
Aetiology
Gene Expression (I)
Gene Expression (II)
Sciencebase
Pharyngula
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
A Scientist's Life
Speculist
Cosmic Variance
The Capsule
Zeroth Order Approximation
Biology News Net


Medical Blogs
Med Tech Sentinel
DB's Medical Rants
Science-Based Medicine
GruntDoc
The Health Care Blog
Respectful Insolence
Black Triangle
Diabetes Mine


Economics and Business
Marginal Revolution
Arnold Kling
The Volokh Conspiracy
Knowledge Problem
The Stalwart


Politics / Current Events
Virginia Postrel
Tinkerty Tonk
Instapundit
Megan McArdle
Mickey Kaus
Colby Cosh
Alien Corn
No Watermelons


Belles Lettres
Two Blowhards
Critical Mass
Arts and Letters Daily
God of the Machine
Armavirumque
About Last Night
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Merck's Latest Underwhelming Data | Main | A Question For the Crowd »

May 18, 2006

Vial Number Thirty-Three

Email This Entry

Posted by Derek

This morning I got the results in from the first experiments that I spoke about here. Most of them did nothing at all. Nothing in the blank controls, nothing in the experimental wells.

There were forty vials to examine, and there was nothing to report for quite a while. But vial number 33, that one appears to have worked. If the reading from it is accurate. I can hardly believe what I'm seeing,

But einmal ist keinmal, especially where wonderful results are concerned. I'm coming in over the weekend to set more controls and repeats to have them done on Monday, which is the next chance I'll have to get anything analyzed. If I can make it happen again, I've just had the most interesting and important result of my entire scientific career.

And I just can't tell you how surprised I am at that possibility.

Comments (16) + TrackBacks (0) | Category: Birth of an Idea


COMMENTS

1. Novice Chemist on May 18, 2006 7:59 PM writes...

Best of luck. .

Permalink to Comment

2. Brooks Moses on May 18, 2006 8:14 PM writes...

Congratulations! May it be real, and repeatable!

Permalink to Comment

3. heziris on May 18, 2006 8:38 PM writes...

whilst doing a final web search for anything that i may have missed for my extended essay on the potential of herbal remedies for depression, came across your blog via your post on castren's review in neuroscience.

this is a simply brilliant website! i do hope all works out well with the above experiment.

best wishes

Permalink to Comment

4. POCl on May 18, 2006 10:13 PM writes...

Best wishes, Derek.

Permalink to Comment

5. Dave on May 19, 2006 12:22 AM writes...

Derek, here's to the reproducibility of your result!

Congrats, and keep the faith!

Permalink to Comment

6. Joseph on May 19, 2006 12:41 AM writes...

Wish you all the best. Am eager to see the future posts regarding the results.

Permalink to Comment

7. austere on May 19, 2006 7:58 AM writes...

good luck.

Permalink to Comment

8. Novice Chemist on May 19, 2006 9:20 AM writes...

Amen to the hopes for reproducibility, BTW.

Permalink to Comment

9. Milo on May 19, 2006 10:06 AM writes...

Derek,

Great news. It is always good to get that one vial that behaves differently than all rest, that is where wonderful science can happen.

Best of luck.

Permalink to Comment

10. Demosthenes by day on May 19, 2006 10:07 AM writes...

Nothing like heading into the weekend on the crest of a positive result.
I wish I had a positive result to head into my weekend. But as usual its another weekend of thinking how to fix this week's problems.

Permalink to Comment

11. Mark Senak on May 19, 2006 11:29 AM writes...

Here's to Pete and RePete!

Permalink to Comment

12. Mark on May 19, 2006 11:44 AM writes...

Seriuosly Derek,

The suspense is killing us!

Permalink to Comment

13. Denni on May 19, 2006 12:11 PM writes...

Best of Luck!

This reminds me of 'fraction 17', on which about half my thesis was hanging ;)

It pretty much summarizes all that I love and loathe about science...

Permalink to Comment

14. Abel Pharmboy on May 19, 2006 2:16 PM writes...

Over a dozen comments and no one has remarked on the coincidence of the number 33 and Rolling Rock beer?? I guess I've given away where I was an undergrad - if it truly pans out for you, Derek, I'll be sending you a case of Latrobe's finest!

Permalink to Comment

15. srp on May 19, 2006 6:47 PM writes...

Best of luck on this. It's surprisingly exciting even vicariously, even not knowing what you're doing, and even probably not understanding it if you told me. I guess that's the true romance of science.

Permalink to Comment

16. Erich Schwarz on May 19, 2006 9:15 PM writes...

Good grief!

Good luck!

Permalink to Comment

POST A COMMENT




Remember Me?



EMAIL THIS ENTRY TO A FRIEND

Email this entry to:

Your email address:

Message (optional):




RELATED ENTRIES
Academia and Industry, Suing Each Other
Let's Start Off the Meeting With An Ad, OK?
The Academic-Industrial Collaboration in Drug Discovery Panel: Today
Glass Structure, Atom by Atom
How the Andrulis Paper Got Published
AstraZeneca in Waltham
Fluorine NMR: Why Not?
AstraZeneca Layoffs and Closings