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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« James Cramer, Biocryst, and You | Main | Procrastination Assistance »

October 18, 2005

Waiting for Pargluva

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Posted by Derek

Well, that title above doesn't sound like something you'll see on a Broadway marquee, does it? As predicted here, although it didn't exactly take psychic powers, the FDA has asked for more cardiovascular data for the new PPAR alpha-gamma drug Pargluva.

Merck and Bristol-Meyers Squibb are quoted as saying that they're "eager to talk" to the agency to find out what's required, and I'll bet they are. Analysts have pushed the likely launch date of the drug back to late next year.

I'm starting to wonder if the PPAR drugs are ever going to able to live up to the expectation that many people had for them. The whole point of an alpha-gamma combination was to reduce blood sugar and improve cardiovascular health at the same time, which makes the emergence of cardiovascular risk with Pargluva particularly annoying.

That whole nuclear receptor field is still a wonderful area for basic research, but turning things into useful drugs has been harder than anticipated. For a while there, it looked as if we'd be able to take all sorts of combination of the three subtypes and turn out drugs for all sorts of indications - diabetes, high blood lipids, various cancers, wound healing, what have you. And perhaps we still can, after another ten or twenty years of hard labor.

(Some of my personal history with these compounds will be illustrated within the next month or so in Bioorganic and Medicinal Chemistry Letters, for those who are interested.)

Comments (2) + TrackBacks (0) | Category: Diabetes and Obesity


COMMENTS

1. milo on October 19, 2005 3:10 PM writes...

It is always nice to hear some opinions on PPARs... We have some folks here working on them, the impression I get is that a lot of things interact with them, so much that a definite SAR is hard to come by. At least that is what I hear in the hallway. It is also nice to see you have an article in BMCL. I have really come to enjoy reading it. All the info and 1/4 the bloat of JMC, plus no CHN data required. Hmmm...that sounds like a beer commercial.

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2. daen on October 24, 2005 6:46 PM writes...

BRISTOL-MEYERS SQUIBB:
  You say we have to submit more cardiovascular data tomorrow? 
MERCK:
  Yes. 
BMS:
  Then we can also bring a good bit of rope. 
MERCK: 
  Yes. 
Silence.
BMS:
  I can't go on like this. 
MERCK:
  That's what you think. 
BMS:
  If we parted? That might be better for us. 
MERCK:
  We'll hang ourselves tomorrow. (Pause.) Unless Pargluva is approved. 
BMS: 
  And if it's approved? 
MERCK: 
  We'll be saved. 

(With copious apologies to Samuel Beckett)

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