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May 4, 2005
Another Law of the Lab
This time, it's the libelous assertion that:
You should only believe yields in Tetrahedron Letters papers if you also send off for everything you see advertised on late-night TV.
Well, that's a little unfair. Not completely unfair - just a little. There are papers in Tet Lett whose procedures are perfectly reproducible - I've used some of them. And on the other hand, there are impressive full papers in JACS that have steps whose efficiency could only be reproduced by angels or advanced space aliens. I shouldn't be so hard on one particular journal. But I'll stand by the principle behind this one, and extend it to include other brief communications in the journals that specialize in them. Chemical Communications is a worthy example from England, and Chemistry Letters gets the nod from Japan, and how.
Why the scepticism? I know that the editors of Tet Lett have been trying to remedy the situation, and things have certainly improved from the days when I wrote that law back in grad school. But people often use these journals as dumping grounds of one sort or another. When there's not enough room to write out full experimentals, who can say you're wrong? Three carbon-carbon bonds formed in the same reaction. . .hmmm. . .how about 85% yield? Do I hear 96%? Sold! If the scheme in the paper just has a lithium reagent drawn over an arrow, who's to say that they didn't optimize it out the wazoo with some esoteric blend of solvents and temperatures? Without a full experimental section, we'll never know.
There's always going to be a residue of doubt around a paper that lacks full details. With apologies to the non-chemists in the audience, it's time for some lingo: You say you took off a trityl group and your THP stayed on? Show me. Tell me just how you did that, so I can see if I believe it. You say you got a 94% conversion with that exotic chiral zinc reagent? Peachy! Tell me how you made it - and that includes what kind of zinc it was, and where you bought the darn stuff. I'd like to do that reaction, too, and seeing a bunch of arrows and yields isn't going to help me much.
The idea of the shorter-length journals (or should I say, the ideal) is that they'd be used for preliminary communications of work that would be reported in full later on. Sometimes they are, but I'd like for someone to go to the trouble of seeing just how often that really happens. No one, as far as I know, has ever done that (and I'm not holding my breath, because it'd be a bibliographic nightmare,) but it would be interesting.
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