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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« A Technical Question | Main | Maybe They Should Fire Them All? »

February 7, 2005

One Problem Solved, Anyway

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Posted by Derek

Before I start off tonight, I wanted to welcome another advertiser on the site, the folks at GenomeWeb over there in the corner. Glad to have 'em!

Thanks to the people who commented on yesterday's question. My Corantean overlord(s) suggested a useful solution as well, since (as Jack Vinson guessed), I'm set up to only display the most recent posts on the front page. Pasting in the old material, saving it as a draft, and then changing its date sends it directly to the category without having it appear up front.

So, the first thing I've added from the archives is my series on chemical warfare, which was written in September of 2002. It's in that "Chem/Bio Warfare" category over on the right, naturally enough. (This was written in the run-up to the Iraq war, and the last post in the series was soon overtaken by events. I note, though, that I speculated that Iraq might have far less in its stockpiles than people had estimated - I just didn't realize quite how much less.) But most of the series is still worth a read, if you're interested in that sort of thing. You'll learn about the morning that a German chemist first synthesized a human nerve gas, not realizing quite what he'd made until it was time to dive for the door. And you'll hear about my own cold-sweat encounter with phosgene gas, which I hope not to repeat any time soon.

This'll be it for tonight. I'll be heading into the lab tomorrow morning to see if I have a useful one-pot way to make a five-membered heterocycle, or if I have an orange mess in the bottom of my flask. The most likely outcome is that it won't work, and if it works, the most likely result is two different isomers (with the wrong one predominating.) But I don't know any of that for sure, and that's why we run the darn experiments, y'know. Hope springs eternal - that's one thing we prove in research every morning.

Comments (1) + TrackBacks (0) | Category: Blog Housekeeping


COMMENTS

1. jsinger on February 9, 2005 9:49 AM writes...

The GenomeWeb daily email service is very worth signing up for...

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